Keith A. Matz

Liquid Chromatographic Analysis for Flecainide with Use of a Microbore Column and Ultraviolet Detection

Abstract We describe a simple, isocratic high-performance liquid chromatographic method for measuring the oral antiarrhythmic agent flecainide acetate in serum or plasma. Sample analysis involves a simple organic extraction followed by chromatography on a microbore reverse phase column with ultraviolet detection at 298 nm.

Liquid chromatographic analysis for flecainide with use of a microbore column and small sample volume

Abstract We describe a simple, isocratic high-performance liquid chromatographic method for measuring the oral antiarrhythmic agent flecainide acetate in serum or plasma. Sample analysis involves a single step extraction followed by chromatography on a microbore reverse phase column with fluorescence detection.

Thornton Lake Reflections

This photo was made in Michigans Upper Peninsula near the city of Munising. Almost every year, I spend at least 1 week up there and often will go back to favorite spots. On …

Butterfly Universe 1

The butterfly universe photo was made using water sprayed on glass that had been treated with Duponts Rain X, which allows the droplets to be much larger than normal. The droplets become wide-angle lenses when …

High-performance liquid chromatographic analysis of cyclosporin G (Nva2-cyclosporine) in human blood.

A sensitive high-performance liquid chromatographic method for the analysis of the immunosuppressant cyclosporin G (OG 37–325, Nva2-cyclosporine, CsG) in whole blood has been developed. Sample preparation, employing cyclosporin A (CsA) as internal standard, involves organic extraction with methyl t-butyl ether under sequential acidic and basic conditions. Chromatography is performed using a 2 mm inside diameter x 25 cm column packed with 5 μm octyl (C8) material. An isocratic mobile phase comprised of acetonitrile:methanol:water, at a flow rate of 0.4 ml/min, is utilized. Separation is monitored at 230 nm. Data are also presented that demonstrate the use of CsG as an alternative internal standard to cyclosporin D for liquid chromatographic determinations of CsA.