Keith Chadwick
University of Manchester
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Publication
Featured researches published by Keith Chadwick.
CrystEngComm | 2009
Keith Chadwick; Roger J. Davey; Ghazala Sadiq; Wendy Cross; Robin G. Pritchard
The construction of the ternary phase diagram urea–glutaric acid–water has led to the discovery of a new co-crystal form.
Journal of Pharmaceutical Sciences | 2010
Sarah Boyd; Kevin Back; Keith Chadwick; Roger J. Davey; Colin C. Seaton
The solubility and crystal growth of the 1:1 cocrystal between benzoic acid and isonicotinamide from 95% ethanol was studied through the creation of a ternary phase diagram at differing temperatures and turbidity measurements. From the solubility measurements thermodynamic properties of the system were evaluated, which indicate little solution binding of the two components supported by in situ FT-IR spectra. Cooling crystallisation from solutions of differing composition suggests differing crystal growth characteristics. An excess of benzoic acid appears to increase the metastable zone width and reduce the crystal size through interactions along the fastest growth axis, while an excess of isonicotinamide decreases the metastable zone width with increased crystal size.
Langmuir | 2013
Justin Quon; Keith Chadwick; Geoffrey P. F. Wood; Iris Sheu; Blair K. Brettmann; Allan S. Myerson; Bernhardt L. Trout
We investigated the effect of spherical agglomeration of heterogeneous crystalline substrates on the nucleation of acetaminophen (AAP). Optical and electron microscopy showed that the surface morphologies of single crystal triclinic lactose and D-mannitol differed significantly from their counterparts formed via spherical agglomeration. Spherical agglomerates of lactose were shown to enhance the nucleation rate of acetaminophen (AAP) by a factor of 11 compared to single crystal lactose; however, no such enhancement was observed for D-mannitol. X-ray powder diffraction identified the presence of new crystal faces of lactose present only in the spherical agglomerates However, D-mannitol did not show any significant change in crystal morphology. The new crystal faces of triclinic lactose were analyzed using geometric lattice matching software and molecular dynamics simulations to establish any new and significant epitaxial matches between lactose and AAP. A coincident lattice match and a large favorable energy interaction from hydrogen bonding were observed between the (141¯) and (001) crystal faces of lactose and AAP, respectively. The enhanced nucleation kinetics, X-ray data, and computational studies indicated that the spherical crystallization of lactose exposed the (141¯) face on the surface of the agglomerates, which subsequently enhanced the nucleation rate of AAP through geometric lattice matching and molecular functionality. This study highlights the importance of exploring different heterogeneous substrate morphologies for enhancing nucleation kinetics.
CrystEngComm | 2007
Keith Chadwick; Roger J. Davey; Wendy Cross
Crystal Growth & Design | 2012
Keith Chadwick; Jie Chen; Allan S. Myerson; Bernhardt L. Trout
Crystal Growth & Design | 2010
Colin C. Seaton; Keith Chadwick; Ghazala Sadiq; Kun Guo; Roger J. Davey
Industrial & Engineering Chemistry Research | 2014
Mo Jiang; Xiaoxiang Zhu; Mark C. Molaro; Michael L. Rasche; Haitao Zhang; Keith Chadwick; Davide Martino Raimondo; Kwang-Ki K. Kim; Lifang Zhou; Zhilong Zhu; Min Hao Wong; Des O’Grady; Dominique Hebrault; John Tedesco; Richard D. Braatz
Crystal Growth & Design | 2009
Keith Chadwick; Ghazala Sadiq; Roger J. Davey; Colin C. Seaton; Robin G. Pritchard; Andrew Parkin
Crystal Growth & Design | 2016
David Acevedo; Jing Ling; Keith Chadwick; Zoltak K. Nagy
Crystal Growth & Design | 2016
Mitulkumar A. Patel; Kyle Kaplan; Simseok A. Yuk; Sugandha Saboo; Kassandra Melkey; Keith Chadwick