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Dive into the research topics where Keith Chadwick is active.

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Featured researches published by Keith Chadwick.


CrystEngComm | 2009

The utility of a ternary phase diagram in the discovery of new co-crystal forms

Keith Chadwick; Roger J. Davey; Ghazala Sadiq; Wendy Cross; Robin G. Pritchard

The construction of the ternary phase diagram urea–glutaric acid–water has led to the discovery of a new co-crystal form.


Journal of Pharmaceutical Sciences | 2010

Solubility Metastable Zone Width Measurement and Crystal Growth of the 1:1 Benzoic Acid/Isonicotinamide Cocrystal in Solutions of Variable Stoichiometry

Sarah Boyd; Kevin Back; Keith Chadwick; Roger J. Davey; Colin C. Seaton

The solubility and crystal growth of the 1:1 cocrystal between benzoic acid and isonicotinamide from 95% ethanol was studied through the creation of a ternary phase diagram at differing temperatures and turbidity measurements. From the solubility measurements thermodynamic properties of the system were evaluated, which indicate little solution binding of the two components supported by in situ FT-IR spectra. Cooling crystallisation from solutions of differing composition suggests differing crystal growth characteristics. An excess of benzoic acid appears to increase the metastable zone width and reduce the crystal size through interactions along the fastest growth axis, while an excess of isonicotinamide decreases the metastable zone width with increased crystal size.


Langmuir | 2013

Templated Nucleation of Acetaminophen on Spherical Excipient Agglomerates

Justin Quon; Keith Chadwick; Geoffrey P. F. Wood; Iris Sheu; Blair K. Brettmann; Allan S. Myerson; Bernhardt L. Trout

We investigated the effect of spherical agglomeration of heterogeneous crystalline substrates on the nucleation of acetaminophen (AAP). Optical and electron microscopy showed that the surface morphologies of single crystal triclinic lactose and D-mannitol differed significantly from their counterparts formed via spherical agglomeration. Spherical agglomerates of lactose were shown to enhance the nucleation rate of acetaminophen (AAP) by a factor of 11 compared to single crystal lactose; however, no such enhancement was observed for D-mannitol. X-ray powder diffraction identified the presence of new crystal faces of lactose present only in the spherical agglomerates However, D-mannitol did not show any significant change in crystal morphology. The new crystal faces of triclinic lactose were analyzed using geometric lattice matching software and molecular dynamics simulations to establish any new and significant epitaxial matches between lactose and AAP. A coincident lattice match and a large favorable energy interaction from hydrogen bonding were observed between the (141¯) and (001) crystal faces of lactose and AAP, respectively. The enhanced nucleation kinetics, X-ray data, and computational studies indicated that the spherical crystallization of lactose exposed the (141¯) face on the surface of the agglomerates, which subsequently enhanced the nucleation rate of AAP through geometric lattice matching and molecular functionality. This study highlights the importance of exploring different heterogeneous substrate morphologies for enhancing nucleation kinetics.


CrystEngComm | 2007

How does grinding produce co-crystals? Insights from the case of benzophenone and diphenylamine

Keith Chadwick; Roger J. Davey; Wendy Cross


Crystal Growth & Design | 2012

Toward the Rational Design of Crystalline Surfaces for Heteroepitaxy: Role of Molecular Functionality

Keith Chadwick; Jie Chen; Allan S. Myerson; Bernhardt L. Trout


Crystal Growth & Design | 2010

Designing Acid/Acid Co-Crystals through the Application of Hammett Substituent Constants

Colin C. Seaton; Keith Chadwick; Ghazala Sadiq; Kun Guo; Roger J. Davey


Industrial & Engineering Chemistry Research | 2014

Modification of Crystal Shape through Deep Temperature Cycling

Mo Jiang; Xiaoxiang Zhu; Mark C. Molaro; Michael L. Rasche; Haitao Zhang; Keith Chadwick; Davide Martino Raimondo; Kwang-Ki K. Kim; Lifang Zhou; Zhilong Zhu; Min Hao Wong; Des O’Grady; Dominique Hebrault; John Tedesco; Richard D. Braatz


Crystal Growth & Design | 2009

Designing acid acid co-crystals-the use of hammett substitution constants

Keith Chadwick; Ghazala Sadiq; Roger J. Davey; Colin C. Seaton; Robin G. Pritchard; Andrew Parkin


Crystal Growth & Design | 2016

Application of Process Analytical Technology-Based Feedback Control for the Crystallization of Pharmaceuticals in Porous Media

David Acevedo; Jing Ling; Keith Chadwick; Zoltak K. Nagy


Crystal Growth & Design | 2016

Utilization of Surface Equilibria for Controlling Heterogeneous Nucleation: Making the “Disappeared” Polymorph of 3-Aminobenzensulfonic Acid “Reappear”

Mitulkumar A. Patel; Kyle Kaplan; Simseok A. Yuk; Sugandha Saboo; Kassandra Melkey; Keith Chadwick

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Roger J. Davey

University of Manchester

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Ghazala Sadiq

University of Manchester

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Allan S. Myerson

Massachusetts Institute of Technology

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Bernhardt L. Trout

Massachusetts Institute of Technology

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Blair K. Brettmann

Massachusetts Institute of Technology

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