Keith Coburn

Applications of solid supported azide anion: a one-pot, two-step preparation of functionalized 1,2,3-triazoles

Functionalized 1,2,3-triazoles were prepared in a one-pot, two-step synthesis from alkyl halides and alkynes using a polymer supported azide. Two different base resins were examined. The chemistry is suitable for the preparation of combinatorial libraries.

Solid-phase synthesis of functionalized 1,2,3-triazoles

Functionalized 1,2,3-triazoles are prepared by 2+3 cycloaddition of resin bound α-azido esters with substituted alkynes. The reaction is regioselective when the electron-deficient alkyne methyl propiolate is used.

Solid-phase synthesis of functionalized 1,2,4-triazin-6-ones

The solid supported synthesis of functionalized 1,2,4-triazin-6-ones from resin bound amino acids and acid chlorides is described. A thioamide intermediate is generated with Lawessons reagent, and the final products are cyclized and cleaved from resin with hydrazine. The products are obtained in good yield and purity.

A simple method for the preparation and selective functionalization of 4,5-diaminopyrazoles

Abstract A simple procedure for the synthesis and further functionalization of 4,5-diaminopyrazoles using mild conditions is reported herein. The desired products were obtained in good yield, and the structures have been confirmed by X-ray crystallography.