Keith S. Ditman

A controlled study of imipramine (Tofranil) in the treatment of childhood enuresis

In a double-blind, placebo-controlled study with corssver, 47 enuretic children (aged 5 to 16 years) were treated for 8 weeks. It was found that imipramine in doses of 25 or 50 mg. (for children 12 years of age and over) was markedly superior, clinically and statistically (p

Amitriptyline in childhood enuresis

In a double‐blind, placebo‐controlled study with cross‐over, 50 outpatient enuretic children (aged 5 to 15) were treated for 8 weeks. It was found that amitriptyline in doses of 25 or 50 mg. (for children aged 12 and over) was superior clinically (P < 0.0005) to a placebo in decreasing the frequency of nights with enuresis. Adverse effects from the amitriptyline were found to be minimal. After the 8 week treatment period, the dosage of amitriptyline at bedtime was manipulated over a range of 25 to 75 mg. and the clinical response was improved in some instances. Five children (10 per cent) became completely dry and remained dry after the drug was gradually withdrawn. Thirty children (62 per cent) showed various degrees of improvement with a small percentage of relapses when the drug was withdrawn. Fourteen (28 per cent) failed to benefit from treatment.

Dimensions of the LSD, methylphenidate and chlordiazepoxide experiences

SummaryThrough the retrospective use of the 156 item DWM Card Sort, the experiences from a single intravenous dose of 200 mcg of LSD, 75 mg of methylphenidate (Ritalin) and 75 mg of chlordiazepoxide (Librium) were compared in a population of 99 chronic male alcoholics treated in an “LSD setting” in a double-blind study. Surprisingly, 96 of the 156 items proved significantly different among the 3 groups. LSD was unique in producing Sensory and Perceptual Distortions (including Hallucinations or Illusions), and Mystical, Religious or Paranormal Sensations. However, contrary to expectation, LSD did not uniquely produce the traditional “therapeutic” experience, but appeared to be surpassed in that area by methylphenidate. Both drugs also produced some anxiety, while chlordiazepoxide produced relaxation, and enhanced music appreciation.