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Publication
Featured researches published by Kejian Liu.
Environmental Toxicology and Pharmacology | 2017
Shimin Zhang; Xiang Li; Fuwei Xie; Kejian Liu; Huimin Liu; Jianping Xie
Cigarette smoke is a complex and oxidative aerosol. Previous researches on the hazards of cigarette smoke mainly focused on the adverse bioeffects induced by its condensates or gas vapor phase, which ignored the dynamic processes of smoking and the cigarette smoke aging. To overcome these disadvantages, we performed air-liquid interface exposure of whole smoke, which used native and unmodified smoke and ensured the exposure similar to physiological inhalation. Our results indicated that whole cigarette smoke induced lung epithelial cells (A549) and bronchial epithelial cells (BEAS-2B) damages in cytotoxicity assays (methyl thiazoly tetrazolium and neutral red uptake assays). In addition, A549 and BEAS-2B cells showed oxidative damages in whole smoke exposure, with concentration change of several biomarkers (reduced and oxidized glutathione, malondialdehyde, 4-hydroxyhydroxy-2-nonenal, extracellular superoxide dismutase, and 8-hydroxyl deoxyguanosine). These results indicate that whole smoke-induced oxidative stress occurs in two different kinds of cells at air-liquid interface.
Journal of Separation Science | 2010
Li Ding; Fuwei Xie; Guowang Xu; Kejian Liu; Sheng Wang; Jianping Xie
Integration of normal-phase LC (NPLC) fractionation with RPLC-ESI/MS was established to detect the polar fractions of cuticular components from Oriental tobacco leaf. NPLC was selected for the fractionation of polar components of cuticular leaf extract, after being concentrated with rotary evaporator, each of the enriched fractions was further analyzed by RPLC-ESI/MS. In total, 83 compounds were finally detected including 45 cembranoids, 15 labdanoids, 20 sucrose esters, and 3 glucose esters (or fructose esters). Three cembranoids and seven labdanoids possibly are new diterpenoids. Glucose esters (or fructose esters) are also reported in Nicotiana tobacco for the first time.
Inhalation Toxicology | 2016
Hongbo Wang; Xiang Li; Junwei Guo; Bin Peng; Huapeng Cui; Kejian Liu; Sheng Wang; Yaqiong Qin; Peijian Sun; Le Zhao; Fuwei Xie; Huimin Liu
Abstract To accurately estimate the risk of inhaling cigarette smoke containing toxic chemicals, it is important that the distribution of these chemicals is accurately measured in cigarette smoke aerosol particles of various sizes. In this study, a single-channel smoking machine was directly coupled to an electrical low-pressure impactor. The particles of mainstream cigarette smoke were collected using 12 polyester films, and the particulate matter (PM) was characterized. Nicotine, tobacco-specific N-nitrosamines (TSNAs, including NNN, NAT, NAB, and NNK), polycyclic aromatic hydrocarbons (PAHs, including benzo(a)pyrene (BaP), benzo(a)anthracene, and chrysene), and heavy metals (including Cr, As, Cd, and Pb) present in the particles of different sizes were analyzed by GC, HPLC-MS/MS, GC/MS, or ICP-MS, respectively. The results demonstrated that the nicotine, TSNAs, PAHs, and heavy metals in mainstream cigarette smoke were dispersed over a particle size ranging from 0.1 μm to 2.0 μm, and the concentration of these toxic chemicals initially increased and then decreased the particle size grew. The distribution of nicotine was uniform for the PM in the size ranges of less than 0.1 μm, 0.1–1.0 μm, and 1.0–2.0 μm, TSNAs and heavy metals in particles of less 0.1 μm were more abundant, and PAHs in fine particles were also more abundant.
Archive | 2010
Huimin Liu; Kejian Liu; Sheng Wang; Qiaoling Xia; Fuwei Xie; Quanping Yan; Xiaogang Zhang
Archive | 2012
Jingjing Yu; Sheng Wang; Ge Zhao; Yaqiong Qin; Li Ding; Kejian Liu; Fuwei Xie; Xiaobing Zhang
Archive | 2011
Kejian Liu; Fuwei Xie; Li Ding; Le Zhao
Archive | 2009
Qiaoling Xia; Fuwei Xie; Bing Wang; Sheng Wang; Kejian Liu; Huimin Liu
Archive | 2008
Sheng Wang; Fuwei Xie; Bing Wang; Kejian Liu; Huimin Liu
Archive | 2011
Le Zhao; Fuwei Xie; Li Ding; Kejian Liu
Archive | 2012
Bin Peng; Kejian Liu; Jizhao Guo; Quanping Yan; Yaqiong Qin; Xiang Li; Cong Nie