Kelly LaMarco

Clinician-investigators as translational bioscientists: shaping a seamless identity.

Established biomedical scientists counsel early-career clinician-investigators and translational bioscientists on mechanisms for molding successful research careers that advance clinical medicine. Established biomedical scientists counsel early-career clinician-investigators and translational bioscientists on mechanisms for molding successful research careers that advance clinical medicine.

William Heberden and reverse translation.

Eighteenth-century physician-scientist William Heberden transformed science, medicine, and society in ways that remain relevant today. Beginning with the 18th-century physician-scientist William Heberden, the elder, Science Translational Medicine introduces a new article series about historical figures whose transformational contributions to science, medicine, and society remain relevant today.

Science of aging knowledge environment: one-stop shopping for researchers in the field of aging.

The Science of Aging Knowledge Environment (SAGE KE) was launched in October 2001 to provide an online information source and community-building tool. The site offers a wide range of features, including original commentary articles, a database of genes and interventions related to aging, and a calendar of meetings and events. Users may initiate discussions and post comments on the articles; these features are intended to promote interaction between researchers in the field and to ensure the timeliness of information posted. This paper details SAGE KEs contents and offers suggestions about how to customize the site to save time and maximize information acquisition and exchange.

Basic science: Stingy support stalls innovation

A compilation of case studies suggests that the decline in investment in U.S. basic science research threatens innovation and thus the U.S. economy.

Going Organic Yields a Super Model System

A new organ-on-a chip microdevice models the human alveolar-capillary interface—the key functional unit of the living lung—and mimics organ-level functions.

Personalized Medicine Progresses One Base at a Time

A high-fidelity, low-cost, scalable platform for whole-genome sequencing may reveal rare genetic variants and catalyze genomics-based personalized medicine.

Metabolites on the Brain

A mutated metabolic enzyme gains a new catalytic activity that may enhance the progression of metastatic brain cancer. A mutated metabolic enzyme gains a new catalytic activity that may enhance the progression of metastatic brain cancer.