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Dive into the research topics where Kelly Windmill is active.

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Featured researches published by Kelly Windmill.


Experimental and Clinical Endocrinology & Diabetes | 2016

Pathways of Acetyl-CoA Metabolism Involved in the Reversal of Palmitate-Induced Glucose Production by Metformin and Salicylate

B. Hayward; J. C. Molero; Kelly Windmill; Andrew Sanigorski; Jm Weir; N. L. McRae; Kathryn Aston-Mourney; Brenna Osborne; Bing M. Liao; Ken Walder; Peter J. Meikle; Nicky Konstantopoulos

The pathways through which fatty acids induce insulin resistance have been the subject of much research. We hypothesise that by focussing on the reversal of insulin resistance, novel insights can be made regarding the mechanisms by which insulin resistance can be overcome. Using global gene and lipid expression profiling, we aimed to identify biological pathways altered during the prevention of palmitate-induced glucose production in hepatocytes using metformin and sodium salicylate. FAO hepatoma cells were treated with palmitate (0.075 mM, 48 h) with or without metformin (0.25 mM) and sodium salicylate (2 mM) in the final 24 h of palmitate treatment, and effects on glucose production were determined. RNA microarray measurements followed by gene set enrichment analysis were performed to investigate pathway regulation. Lipidomic analysis and measurement of secreted bile acids and cholesterol were also performed. Reversal of palmitate-induced glucose production by metformin and sodium salicylate was characterised by co-ordinated down-regulated expression of pathways regulating acetyl-CoA to cholesterol and bile acid biosynthesis. All 20 enzymes that regulate the conversion of acetyl-CoA to cholesterol were reduced following metformin and sodium salicylate. Selected findings were confirmed using primary mouse hepatocytes. Although total intracellular levels of diacylglycerol, triacylglycerol and cholesterol esters increased with palmitate, these were not, however, further altered by metformin and sodium salicylate. 6 individual diacylglycerol, triacylglycerol and cholesterol ester species containing 18:0 and 18:1 side-chains were reduced by metformin and sodium salicylate. These results implicate acetyl-CoA metabolism and C18 lipid species as modulators of hepatic glucose production that could be targeted to improve glucose homeostasis.


Toxicological Sciences | 2006

Human Sulfotransferases and Their Role in Chemical Metabolism

Niranjali U. Gamage; Amanda C. Barnett; Nadine Hempel; Ronald G. Duggleby; Kelly Windmill; Jennifer L. Martin; Michael E. McManus


Toxicological Sciences | 2000

Localization of N-Acetyltransferases NAT1 and NAT2 in Human Tissues

Kelly Windmill; Andrea Gaedigk; Pauline de la M. Hall; Hema Samaratunga; Denis M. Grant; Michael E. McManus


Diabetes | 2002

Tanis: A Link Between Type 2 Diabetes and Inflammation?

Ken Walder; Lakshmi Kantham; Janine McMillan; James L. Trevaskis; Lyndal Kerr; Andrea de Silva; Terry Sunderland; Nathan Godde; Yuan Gao; Natalie Bishara; Kelly Windmill; Janette Tenne-Brown; Guy Augert; Paul Zimmet; Greg R. Collier


Diabetes | 2000

Beacon: a novel gene involved in the regulation of energy balance.

Greg R. Collier; Janine McMillan; Kelly Windmill; Ken Walder; Janette Tenne-Brown; Andrea de Silva; James L. Trevaskis; Sharon Jones; Gregory J. Morton; Scott Lee; Guy Augert; Anthony Civitarese; Paul Zimmet


Physiological Genomics | 2011

A gene expression signature for insulin resistance.

Nicky Konstantopoulos; Victoria C. Foletta; David Segal; Katherine A. Shields; Andrew Sanigorski; Kelly Windmill; Courtney Swinton; Timothy Connor; Stephen Wanyonyi; Thomas D. Dyer; R. Fahey; Rose A. Watt; Joanne E. Curran; Juan Carlos Molero; Guy Krippner; Greg R. Collier; David E. James; John Blangero; Jeremy B. M. Jowett; Ken Walder


Comparative Biochemistry and Physiology B | 2003

Identification of hypothalamic genes implicated in the development of obesity in Psammomys obesus using differential display PCR

James L. Trevaskis; Janine McMillan; Kelly Windmill; Ken Walder; Greg R. Collier


Journal of Molecular Histology | 2007

Localization and expression of selenoprotein S in the testis of Psammomys obesus

Kelly Windmill; Janette Tenne-Brown; Richard Bayles; James L. Trevaskis; Yuan Gao; Ken Walder; Greg R. Collier


Human cytosolic sulfotransferases | 2005

Human SULT1A SULTs

Nadine Hempel; Amanda C. Barnett; Niranjali U. Gamage; Ronald G. Duggleby; Kelly Windmill; Jennifer L. Martin; Michael E. McManus


Archive | 2001

Novel genes and their use in the modulation of obesity, diabetes and energy imbalance

Gregory Collier; Paul Zev Zimmet; Kenneth Russell Walder; Kelly Windmill; Janine McMillan

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