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Kelvin W. Gee

University of California, Berkeley

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Featured researches published by Kelvin W. Gee.

Nature Medicine | 2004

Modifying quinolone antibiotics yields new anxiolytics

Timothy B.C. Johnstone; Derk J. Hogenkamp; Leanne Coyne; Jiping Su; Robert F. Halliwell; Minhtam B Tran; Ryan F Yoshimura; Wen-Yen Li; Jeffrey C. Wang; Kelvin W. Gee

Patients taking fluoroquinolone antibiotics such as norfloxacin exhibit a low incidence of convulsions and anxiety. These side effects probably result from antagonism of the neurotransmitter γ-aminobutyric acid (GABA) at the brain GABAA receptor complex (GRC). Modification of norfloxacin yields molecules such as compound 4 that potentiate GABA action with α2 subunit selectivity. Compound 4 is anxiolytic but does not cause sedation, and may represent a new class of ligands that have anxiolytic activity without sedative liability.

Archive | 2003

Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof

Timothy B.C. Johnstone; Derk J. Hogenkamp; Kelvin W. Gee

Archive | 2005

Substituted enaminones, their derivatives and uses thereof

Derk J. Hogenkamp; Timothy B.C. Johnstone; Kelvin W. Gee

Archive | 2010

Substituted heterocycles and their use as allosteric modulators of nicotinic and gabaa receptors

Timothy B.C. Johnstone; Derk J. Hogenkamp; Kelvin W. Gee

Archive | 2006

Substituted enaminones as nicotinic acetylcholine receptor modulators

Derk J. Hogenkamp; Timothy B.C. Johnstone; Kelvin W. Gee

Archive | 2015

Long-Term Potentiation in the Hippocampus and Enhances Cognition Allosteric Modulation of Related Ligand-Gated Ion Channels Synergistically Induces

T. V. Dunwiddie; Jerrel L. Yakel; Kelvin W. Gee; Edward R. Whittemore; Jin-Cheng Huang; Minhtam Tran; James D. Belluzzi; Timothy B. Johnstone; Zhenglin Gu; Ryan F. Yoshimura; Anne-Sophie Villégier; J Derk; Hao Huang; Youfen Xu; Anthony N. van den Pol; Jyotirmoy Banerjee; Manickavasagom Alkondon; Edna F. R. Pereira; Edson X. Albuquerque

Archive | 2015

Vibrissa Deflections Neurons in the Rat Thalamic Reticular Nucleus to High Responsiveness and Direction Sensitivity of

Simona Temereanca; Daniel J. Simons; Vivek Khatri; Ryan F. Yoshimura; Jin-Cheng Huang; James D. Belluzzi; Edward R. Whittemore; Kelvin W. Gee; Minhtam Tran; Derk J. Hogenkamp; Timothy B. Johnstone; Ernest E. Kwegyir-Afful; Harold T. Kyriazi; D. J. Simons

Archive | 2004