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Kendra E. Hightower

Duke University

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Publication

Featured researches published by Kendra E. Hightower.

Current Opinion in Chemical Biology | 1999

Zinc-catalyzed sulfur alkylation: insights from protein farnesyltransferase

Kendra E. Hightower; Carol A. Fierke

Zinc metalloenzymes catalyze many important cellular reactions. Recently, the involvement of zinc in the catalysis of alkylation of sulfur groups has gained prominence. Current studies of the zinc metalloenzyme protein farnesyltransferase have shed light on its structure and catalytic mechanism, as well as the general mechanism of zinc-catalyzed sulfur alkylation.

Biochemistry | 1998

H-RAS PEPTIDE AND PROTEIN SUBSTRATES BIND PROTEIN FARNESYLTRANSFERASE AS AN IONIZED THIOLATE

Kendra E. Hightower; Chih-chin Huang; Patrick J. Casey; Carol A. Fierke

Biochemistry | 2000

Mechanistic studies of rat protein farnesyltransferase indicate an associative transition state.

Chih Chin Huang; Kendra E. Hightower; Carol A. Fierke

Biochemistry | 2000

Role of metals in the reaction catalyzed by protein farnesyltransferase.

Matthew J. Saderholm; Kendra E. Hightower; Carol A. Fierke

Biochemistry | 1996

Proteolytic cleavage within a regulatory region of the gamma subunit of chloroplast coupling factor 1.

Kendra E. Hightower; Richard E. McCarty

Biochemistry | 1996

INFLUENCE OF NUCLEOTIDES ON THE COLD STABILITY OF CHLOROPLAST COUPLING FACTOR 1

Kendra E. Hightower; Richard E. McCarty

Biochemical Journal | 2001

Lysine164α of protein farnesyltransferase is important for both CaaX substrate binding and catalysis

Kendra E. Hightower; Smita De; Carolyn Weinbaum; Rebecca A. Spence; Patrick J. Casey

Biochemistry | 2000

Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition.

Rebecca A. Spence; Kendra E. Hightower; Kimberly L. Terry; Lorena S. Beese; Carol A. Fierke; Patrick J. Casey

Biochemistry | 1996

STRUCTURAL STABILITY OF CHLOROPLAST COUPLING FACTOR 1 AS DETERMINED BY DIFFERENTIAL SCANNING CALORIMETRY AND COLD INACTIVATION

Kendra E. Hightower; Richard E. McCarty

Biochemistry | 2001

Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase.

Kendra E. Hightower; Patrick J. Casey; Carol A. Fierke

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Carol A. Fierke

University of Michigan

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Patrick J. Casey

National University of Singapore

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Richard E. McCarty

Johns Hopkins University

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Matthew J. Saderholm

University of North Carolina at Chapel Hill

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Rebecca A. Spence

Duke University

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Carolyn Weinbaum

Duke University

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Chih Chin Huang

Duke University

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Chih-chin Huang

University of Pennsylvania

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Kimberly L. Terry

Duke University

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Lorena S. Beese

Duke University

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