Kengo Kawashima

Hard X-ray Detector (HXD) on board Suzaku

The Hard X-ray Detector (HXD) on board Suzaku covers a wide energy range from 10 keV to 600 keV by combination of silicon PIN diodes and GSO scintillators. The HXD is designed to achieve an extremely low in-orbit back ground based on a combination of new techniques, including the concept of well-type active shield counter. With an effective area of 142 cm^2 at 20 keV and 273 cm2 at 150 keV, the background level at the sea level reached ~1x10^{-5} cts s^{-1} cm^{-2} keV^{-1} at 30 keV for the PI N diodes, and ~2x10^{-5} cts s^{-1} cm^{-2} keV^{-1} at 100 keV, and ~7x10^{-6} cts s^{-1} cm^{-2} keV^{-1} at 200 keV for the phoswich counter. Tight active shielding of the HXD results in a large array of guard counters surrounding the main detector parts. These anti-coincidence counters, made of ~4 cm thick BGO crystals, have a large effective area for sub-MeV to MeV gamma-rays. They work as an excellent gamma-ray burst monitor with limited angular resolution (~5 degree). The on-board signal-processing system and the data transmitted to the ground are also described.

Development of the HXD-II wide-band all-sky monitor onboard Astro-E2

The hard X-ray detector (HXD-II) is one of the three scientific instruments onboard Japanese X-ray astronomy satellite Astro-E2 scheduled to be launched in 2005. This mission is very unique in a point of having a lower background than any other past missions in the 10-600 keV range. In the HXD-II, the large and thick BGO crystals are used as active shields for particle and gamma-ray background to the main detector. They have a wide field of view of ~2pi and a large effective area of 400 cm2 even at 1 MeV. Hence, the BGO shields have been developed as a wide-band all-sky monitor (WAM) with a broadband coverage of 50-5000 keV. In this paper, overall design and performance of the HXD-II/WAM based on the results of preflight calibration tests carried out in June 2004 are described. By irradiating various radio isotopes with the WAM flight model, we verified that it had comparable capabilities with other gamma-ray burst detectors

Improvements of the astro-E2 hard X-ray detector (HXD-II)

We summarize significant improvements which have been achieved in the development of Astro-E2 Hard X-ray Detector (HXD-II). An expanded energy range and better energy resolution have been achieved from progresses in device materials and redesigning of the front-end electronics. An improved estimation for the detector background in orbit has also been conducted based upon results from our proton irradiation experiment. The sensitivity of HXD-II can be expected to reach an order of 10/sup -6/ [cs/sup -1/ keV/sup -1/ cm/sup -2/].

Development and qualification of the HXD-II onboard Astro-E2

The Hard X-ray Detector (HXD-II), one of instruments onboard the Astro-E2 satellite to be launched in February 2005, is in the final stage of its development. The HXD-II probes the universe in the energy range of 10-600 keV with a sensitivity by an order of magnitude better than those of previous missions. The assembly of the HXD-II completed in January 2004, followed by a series of pre-launch qualification tests. As a result, the design goals of the HXD-II have been met. These include; a background level of 5 x 10-6 counts/s/keV/cm2 at 200 keV for GSO and 1 x 10-5 counts/s/keV/cm2 at 30 keV for PIN; energy resolutions of 2.9 keV (PIN diode, at 59.5 keV) and 10% (GSO scintillator, at 662 keV); and low energy thresholds of 10 keV for PIN diodes and 30 keV for GSO scintillators. The measured background predicts a continuum sensitivity of a few x 10-6 photons/s/keV/cm2. Anti-Counter units surrounding the HXD-II provide 50 keV-5 MeV information on gamma-ray bursts and bright X-ray transients.

INTESTINAL METAPLASIA INDUCED BY X-IRRADIATION IN DIFFERENT STRAINS OF RATS

Attempts were made to examine strain differences in the susceptibility of rats to intestinal metaplasia induced by X‐irradiation. The gastric regions of 4 inbred male rats (SHR, F344, WKY, and LEW strains) in 5‐week‐old and 2 random bred male rats (SD, and WIS strains) were irradiated with a total dose of 20 Gy X‐ray given in two equal fractions separated by three days. Upon sacrifice at 6 months after the last irradiation, the number of intestinal metaplastic crypts with positive reaction to alkaline phosphatase (ALP) appeared highest in the SHR and lowest in the WIS rats. Morphologically, the number of crypts with intestinal metaplasia in whole glandular stomachs of SHR, WIS, F344, and SD rats were higher than those in WKY and LEW rats. In the pyloric gland, it was highest in WIS rats, while in the fundic gland it was highest in SHR rats. The results show that the appearance and location of intestinal metaplasia by X‐irradiation are greatly influenced by the strain of the rat. ACTA PATHOL. JPN. 35: 841–847, 1985.

pH-RELATED DIFFERENTIATION IN THE EPITHELIA OF THE GASTRIC MUCOSA OF POSTNATAL RATS

The postnatal development of the gastric mucosa was observed in Long Evans rats. In both pyloric and fundic mucosae, the mitotic index peaked at 5 days of age and then gradually decreased to reach a constant level from 14 days of age onward (P<0.05), the germinal region shifted from the deeper area of the mucosae upward to the middle layer. The number of parietal cells increased gradually (P<0.05). Gastric pH on the mucosal surface decreased from 6 on the day of birth to about 4 at 7 days of age and to about 2 at 28 days of age. The inverse relationship between the number of parietal cells and pH value on gastric mucosa was found to be highly significant (P<0.01). Trehalase and sucrase activities were observed at 7 days of age and lactase and maltase activities from 0 to 14 days of age. In the pyloric mucosae, foveolae containing goblet cells which were positive for Alcian blue‐PAS and HID were observed between 0 and 7 days of age. These cells disappeared by 14 days of age concurrently with the decrease in pH value and increase in the number of parietal cells. ACTA PATHOL. JPN. 35 : 569–576, 1985.

The Induction of Intestinal Metaplasia in Rats by Pyloroplasty or Pyloroplasty plus Vagotomy

The influence of increased gastric pH on induction of intestinal metaplasia in the stomach of male JCL/SD rats was examined following surgical procedures of pyloroplasty or pyloroplasty and vagotomy. Twelve months after pyloroplasty plus vagotomy serum gastric concentrations were significantly higher (group II) than in rats receiving only pyloroplasty (group I) or in sham operated animals (group III). Additionally, trehalase activity was also higher in group II than in groups I and III. The incidence of intestinal metaplasia was significantly higher in groups I and II compared with the sham operated control animals (group III). This study indicates that intestinal metaplasia could be induced by surgical procedures such as pyloroplasty with or without vagotomy. Furthermore, elevation of the pH on gastric mucosa by such procedures may play a significant role in the subsequent development of metaplasia in the stomach.