Kengo Nagaoka

HLA-DR Specifications in Japanese with Juvenile-onset Insulin-Dependent Diabetes Mellitus

Specific allelic associations vary among ethnic groups. We studied the distribution of HLA-A,-B,-C, and -DR antigens in 34 Japanese juvenile-onset diabetic patients. The focus of our current work was HLS-DR antigens because there have been few studies of Japanese with this disease. A significant increase in the frequency of HLA-DR4 was found in patients but not in unaffected persons: DR4 was found in 56.3% of the patients versus 32.6% of the unaffected persons. However, the negative correlation between DR2 and patients was not statistically significant.

Antibodies to Coxsackie B viruses and HLA in Japanese with juvenile-onset Type 1 (insulin-dependent) diabetes mellitus

SummaryOne hundred and three patients with juvenile-onset Type 1 (insulin-dependent) diabetes mellitus have been studied for evidence of previous Coxsackie B virus infection and compared with age- and sex-matched controls. Coxsackie B4 or B3 neutralization titre ⩾ 80 were more common among the patients than among the control subjects, but showed no association with HLA-B phenotypes.

Incidence of Thyroglobulin and Microsomal Antibodies in Normal Subjects

In the course of studies on the occurrence of antithyroid antibodies in various thyroid disorders, serum antibodies to microsome of thyroid epithelial cells, as well as circulating antibodies to thyroglobulin, are demonstrated by tanned red cell hemaggulutination. These thyroglobulin and microsome-coated tanned red blood cells can be efficiently demonstrated with a commercially prepared reagent. (Fuji-Zoki Co.) The sera of 2,350 normal subjects were tested by these thryoid autoantibodies tests. Fifty-one (2.3 per cent) of the sera of 2,350 normal subjects showed a positive reaction for thyroglobulin antibodies, and fifty-nine (2.5 per cent) persons showed a positive reaction for microsomal antibodies. The incidence of thyroglobulin and microsomal antibodies in males and females were progressively greater with age, particularly between ages 60 to 69.

Thyroid autoantibodies, antinuclear factors and HB antigen in various hepatic diseases

最近我が国では抗甲状腺抗体の検出法としてタンニン酸処理赤血球凝集反応を応用したThyroid test,及びMicrosome testがキット化され安定した成績が得られるようになってきた.そこで今回,われわれは正常健康人2,350名を対照とし各種肝疾患患者150名につきThyroid test及びMicrosome testを施行し同時に抗核抗体,HB抗原を検索し,これらの関連について検討した.その結果ルポイド肝炎では他の肝疾患に比し抗甲状腺抗体及び抗核抗体の両方共33.3%と著しく高い陽性率を示した.HB抗原は急性肝炎で35%と最も高い陽性率を示したが抗甲状腺抗体とHB抗原との間には相関する関係は見られず,また明らかな相互離反の傾向も見られなかった.抗甲状腺抗体と抗核抗体との間には明らかに相関する関係が見られた.抗甲状腺抗体は正常健康者と同じく肝疾患全体では男性よりも女性で2倍以上の陽性率を示したが10×28以上の高い抗体価を有する者は1例もなかった.

Thyroglobulin and microsomal antibodies in diabetes mellitus in childhood

The purpose of our study was to determine the incidence of thyroid antibodies in diabetes mellitus in childhood and to discuss the correlation between thyroid antibodies and insulin antibodies. The sera of 50 children with diabetes mellitus and 437 children as disease controls were tested by thyroglobulin and microsome-coated tanned red cell hemagglutination test (Fuji Zoki Co. Tokyo). One of the 50 children with diabetes mellitus (2%) was positive with antithyroglobulin antibodies and eleven (22%) were positive with antimicrosomal antibodies compared to 0.4% and 1.1% respectively in 437 disease controls. To clarify the association of insulin antibodies and thyroid antibodies in diabetes mellitus in childhood, insulin antibodies were demonstrated by using a modified method described by Wright. One of the 33 children with negative insulin antibody (2.8%) was positive with antithyroglobulin antibodies and eight (24%) were positive antimicrosomal antibodies. No evident correlation was observed between antithyroid antibodies and insulin antibodies.

Rheumatoid factor in diabetes mellitus

: This study was undertaken to try to determine the incidence of rheumatoid factor in patients with diabetes mellitus by the Hyland RA slide test and the RAHA test (the sensitized sheep red cell agglutination test). Sera from 507 patients with diabetes mellitus and 2073 controls were investigated for the presence of rheumatiod factors. RA test was positive in 8.7 per cent and RAHA test in 6.1 per cent in sera from patients with diabetes mellitus compared to 4.1 percent and 3.6 per cent respectively in healthy subjects.