Kenji Asai

Effect of pacing mode on sleep disturbance.

Abstract The relationship between pacing mode and sleep is not yet known, and therefore polysomnography was used to evaluate the effect. A total of 16 patients (8 men and 8 women; mean age, 72 ± 9 years) with DDD pacemakers made up the study population. Of these 16 patients, 8 patients had complete AV block and 8 patients had sick sinus syndrome. The recording was done twice in VVI and DDD modes. Between VVI mode and DDD mode, sleep latency time (VVI mode: 38 ± 25, DDD mode 23 ± 27 min), frequency of temporary waking (8.3 ± 6.7, 3.7 ± 2.9 times), the number of episodes of apnea (59 ± 84, 36 ± 55 times, the apnea–hypopnea index (AHI) (15 ± 18, 10 ± 13), and efficacy of sleep (72% ± 10%, 81% ± 11%) were significantly different. Also, the apnea index improved significantly in DDD mode. There was no significant difference in total sleep time and in total duration of temporary waking between the two groups. From the study results, a reduction in sleep disturbance was achieved when DDD pacing mode was chosen, rather than VVI mode. Furthermore, efficacy of sleep also improved significantly compared with VVI mode. Interestingly, sleep apnea syndrome in four patients with AHI ≧ 15 notably ameliorated when DDD mode was chosen; however, the mechanism involved in amelioration is still ambiguous and needs further assessment.

IMPACT OF PLAQUE CHARACTERIZATION ON SUBSEQUENT DEVELOPMENT OF PERI–STENT CONTRAST STAINING AFTER SIROLIMUS–ELUTING STENT IMPLANTATION

Peri–stent contrast staining (PSS) has been recognized as a predictor for very late stent thrombosis after sirolimus–eluting stent (SES) implantation. However, the pathogenesis of PSS remains poorly understood. We analyzed tissue characterization of target plaque before SES implantation and

CLINICAL IMPACT OF INTRACORONARY NICORANDIL INFUSION COMPARED TO INTRAVENOUS ADENOSINE TRIPHOSPHATE ON MEASUREMENT OF FRACTIONAL FLOW RESERVE IN INTERMEDIATE CORONARY LESIONS

Fractional flow reserve (FFR) has been recognized as useful modality to assess functional significance of coronary stenosis. It is important to obtain maximal hyperemia for optimal FFR measurement. Although adenosine triphosphate (ATP) is generally used as hyperemic stimulus, we sometimes encounter

TCT-229 The Safety and Feasibility of Nicorandil Compared to Adenosine Triphosphate as Hyperemic Agents for Fractional Flow Reserve Measurements

Withdrawn

Oral Appliance Therapy for Mild Obstructive Sleep Apnoea Syndrome

Abstract We report a 42-year-old man who was admitted to the Aichi Medical University Hospital, Aichi, Japan, following cardiac arrest and was successfully revived using an automated external defibrillator. Percutaneous catheter intervention was performed and a cardioverter-defibrillator was implanted. The patient was also diagnosed with mild obstructive sleep apnoea syndrome and treated using an oral appliance. His apnoea-hypopnoea index improved from 13.5/ hour to 2.7/hour following the oral appliance treatment, which was continued for more than 3 years after his discharge.