Kenji Kawano

Targeting Cancer therapy in Mice by Use of Newly Developed Immunoliposomes Bearing Adriamycin

AbstractPolysaccharide-coated liposomes have been developed to improve the stability of conventional liposomes against biochemical and physicochemical stimuli. Pullulan (MW 5 × 104) was used as the polysaccharide. the mouse IgM monoclonal antibody (CSLEX 1) recognizes a sialosylated Lex, which is a tumor-specific antigen in athymic mice. the IgM antibody was reduced with cysteine to obtain the subunit (IgMs) that remained biologically active. the IgMs was accumulated in an antigen-positive tumor in vivo. Subsequently, it was conjugated with the pullulan-coated liposome to form an immunoliposome.Tissue distribution studies demonstrated that immunoliposomes were more efficiently targeted to an implanted tumor than to the polysaccharide-coated liposomes. This is accompanied by a drastic decrease in liver uptake of the immunoliposomes. Furthermore, adriamycin-encapsulated immunoliposomes in-hibited the growth of the implanted tumor more effectively than did the simple pulluian-coated liposomes.

A case of primary lung cancer with diffuse sarcoid granuloma in the resected lung.

症例は74才の女性. 7年前よりブドウ膜炎および緑内障にて治療を受け, 胸部X線にて右上肺野に腫瘤影を指摘されていたが放置していたところ, 同陰影が次第に増大の傾向にあるため精査し, 肺腺癌の診断にて右上葉切除を受けた. 切除肺には癌部および非癌部ともにサルコイド肉芽腫をびまん性に認め, 術後の精査にて血清ACE値や, 対側肺の気管支肺胞洗浄液などから, サルコイドーシスの合併が疑われた症例を経験したので報告した.