Kenji Miyahara

Effect of Macroscopic Grooves on Bone Formation and Osteoblastic Differentiation.

Objectives:The aim of this study is to investigate the effect of macroscopic grooves on bone formation in vivo and differentiation of human mesenchymal stem cells (hMSCs) in vitro. Materials and Methods:The effects of macroscopic grooves on titanium alloy implants and disks were tested in rabbit tibiae and cultured hMSCs. The bone-to-implant contact (BIC) and bone area were evaluated in rabbit tibiae at 6 and 24 weeks after implant insertion. Osteoblastic differentiation was assessed by alkaline phosphatase (ALP) activity and real-time reverse-transcription polymerase chain reaction (RT-PCR) on days 7, 14, and 21. All values were statically analyzed. Results:BIC and bone area inside the grooves were significantly higher than those of control implants (P < 0.05). ALP activity was significantly higher for titanium disks with macroscopic grooves than without grooves on day 14 (P < 0.05). Real-time RT-PCR showed that the expression of osteogenic genes was significantly higher for disks with grooves on day 7 (P < 0.01). Conclusions:Macroscopic grooves accelerate osteoblastic differentiation in vitro and stimulate direct bone growth and deposition within the grooves in vivo.

Treatment for Chronic and Broad Osteomyelitis of Femor with Papineau's Method

今回我々は，長期間放置されていた大腿骨の慢性化膿性骨髄炎の3例に対し，Papineau法による治療を行い良好な治療成果が得られたので報告する．症例は男性2例，女性1例で，年齢は60歳～70歳（平均64.7歳）．骨髄炎罹患期間は23年～52年（平均38.0年）であった．第1相～第2相までの日数は平均47.3日，第2相～第3相までは平均28.0日で，入院期間は平均110.0日であった．病巣掻爬の範囲が約20cmに及ぶものが1例あったが，両側前後の腸骨からの骨移植でなんとか骨充填可能であった．第3相は3例とも創の縫縮のみで閉創可能で，再燃は認めていない．〈考察〉慢性化膿性骨髄炎に対してはPapineau法以外にもさまざまな治療法が施行されている．当院ではイリザロフによる仮骨延長法等も症例によっては施行しているが，患者の性格，年齢，罹患部位等を考慮すると，今回のようにPapineau法の有用性が改めて確認できた．

Inverstigation into the Reasons Why Sports Players Retire

We surveyed a group of sports players to investigate the reasons why they retire with particular respect to injury characteristics. Subjects included baseball players (67 males), rugby players (65 males) and basketball players (47 females). Nineteen baseball players, 4 rugby players and 5 basketball players had decided to retire because of injuries and disorders that happened during playing.Among baseball players, lumbar spinal disorders were the most prevalent and they were also characterized by elbow and shoulder disorders. No characteristic disorders were found to be associated with rugby players. In basketball players, knee joint injuries were characteristic, with rerupture of the anterior cruciate ligament a serious injury for them.