Kent J. DeZee

Tricyclic antidepressants and headaches: systematic review and meta-analysis

Objective To evaluate the efficacy and relative adverse effects of tricyclic antidepressants in the treatment of migraine, tension-type, and mixed headaches. Design Meta-analysis. Data sources Medline, Embase, the Cochrane Trials Registry, and PsycLIT. Studies reviewed Randomised trials of adults receiving tricyclics as only treatment for a minimum of four weeks. Data extraction Frequency of headaches (number of headache attacks for migraine and number of days with headache for tension-type headaches), intensity of headache, and headache index. Results 37 studies met the inclusion criteria. Tricyclics significantly reduced the number of days with tension-type headache and number of headache attacks from migraine than placebo (average standardised mean difference −1.29, 95% confidence interval −2.18 to −0.39 and −0.70, −0.93 to −0.48) but not compared with selective serotonin reuptake inhibitors (−0.80, −2.63 to 0.02 and −0.20, −0.60 to 0.19). The effect of tricyclics increased with longer duration of treatment (β=−0.11, 95% confidence interval −0.63 to −0.15; P<0.0005). Tricyclics were also more likely to reduce the intensity of headaches by at least 50% than either placebo (tension-type: relative risk 1.41, 95% confidence interval 1.02 to 1.89; migraine: 1.80, 1.24 to 2.62) or selective serotonin reuptake inhibitors (1.73, 1.34 to 2.22 and 1.72, 1.15 to 2.55). Tricyclics were more likely to cause adverse effects than placebo (1.53, 95% confidence interval 1.11 to 2.12) and selective serotonin reuptake inhibitors (2.22, 1.52 to 3.32), including dry mouth (P<0.0005 for both), drowsiness (P<0.0005 for both), and weight gain (P<0.001 for both), but did not increase dropout rates (placebo: 1.22, 0.83 to 1.80, selective serotonin reuptake inhibitors: 1.16, 0.81 to 2.97). Conclusions Tricyclic antidepressants are effective in preventing migraine and tension-type headaches and are more effective than selective serotonin reuptake inhibitors, although with greater adverse effects. The effectiveness of tricyclics seems to increase over time.

Risk of angioedema with angiotensin receptor blockers in patients with prior angioedema associated with angiotensin-converting enzyme inhibitors: a meta-analysis.

BACKGROUND Patients who have angioedema after taking angiotensin-converting enzyme inhibitors (ACE-Is) have been reported to develop angioedema when taking an angiotensin receptor blocker (ARB), but few studies quantify the risk. OBJECTIVE To perform a systematic review of the literature. METHODS A literature search was performed in MEDLINE, EMBASE, BIOSIS, and Current Contents, with no limitations from January 1990 to May 2007. Any article that described a cohort of patients who had angioedema after taking an ACE-I, were subsequently exposed to an ARB, and were followed for a least 1 month were included. The percentage of patients who had angioedema was abstracted from each article, and confidence intervals were calculated using the exact binomial method. The pooled percentage was calculated with the inverse variance method. RESULTS Two-hundred fifty-four unique articles were identified, and 3 articles met inclusion criteria, which described 71 patients with the outcome of interest. One was a randomized controlled trial and 2 were retrospective cohorts. These articles described both confirmed and possible cases of angioedema. The risk of angioedema was 9.4% (95% confidence interval, 1.6%-17%) for possible cases and 3.5% (95% confidence interval, 0.0%-9.2%) for confirmed cases. No fatal events were reported. No statistical heterogeneity was reported between trials (P > .3). CONCLUSIONS Limited evidence suggests that for patients who develop angioedema when taking an ACE-I, the risk of development of any subsequent angioedema when taking an ARB is between 2% and 17%; for confirmed angioedema, the risk is 0% to 9.2%. This information will aid clinicians in counseling patients regarding therapy options after development of angioedema due to ACE-Is.

Disease and nonbattle injuries sustained by a U.S. Army Brigade Combat Team during Operation Iraqi Freedom.

BACKGROUND A longitudinal cohort analysis of disease nonbattle injuries (DNBI) sustained by a large combat-deployed maneuver unit has not been performed. METHODS A descriptive analysis was undertaken to evaluate for DNBI casualty care statistics incurred by a U.S. Army Brigade Combat Team (BCT) during a counterinsurgency campaign of Operation Iraqi Freedom. RESULTS Of the 4,122 soldiers deployed, there were 1,324 DNBI with 5 (0.38%) deaths, 208 (15.7%) medical evacuations (MEDEVAC), and 1,111 (83.9%) returned to duty. The DNBI casualty rate for the BCT was 257.0/1,000 soldier combat-years. Females, compared with males, had a significantly increased incidence rate ratio for becoming a DNBI casualty 1.67 (95% CI 1.37, 2.04). Of 47 female soldiers receiving MEDEVAC 35 (74%) were for pregnancy-related issues. Musculoskeletal injuries (50.4%) and psychiatric disorders (23.3%) were the most common body systems involved with DNBI casualties. Among the BCT cohort the psychiatric DNBI casualty rate and suicide rate were 59.8 and 0.58 per 1,000 soldier combat-years. The BCT cohort incidence rates for common musculoskeletal injuries per 1,000 combat-years were as follows: ankle sprain 15.3, anterior cruciate ligament rupture 3.3 and shoulder dislocation 1.2. CONCLUSIONS Musculoskeletal injuries and psychiatric disorders accounted for 74% of the total DNBI casualties, and 43% of the DNBI casualties requiring subsequent MEDEVAC. The BCT cohort had a suicide rate nearly four times greater than previously reported, and selected musculoskeletal injury incidence rates were fivefold greater than the general population.

Developing questionnaires for educational research: AMEE Guide No. 87

Abstract In this AMEE Guide, we consider the design and development of self-administered surveys, commonly called questionnaires. Questionnaires are widely employed in medical education research. Unfortunately, the processes used to develop such questionnaires vary in quality and lack consistent, rigorous standards. Consequently, the quality of the questionnaires used in medical education research is highly variable. To address this problem, this AMEE Guide presents a systematic, seven-step process for designing high-quality questionnaires, with particular emphasis on developing survey scales. These seven steps do not address all aspects of survey design, nor do they represent the only way to develop a high-quality questionnaire. Instead, these steps synthesize multiple survey design techniques and organize them into a cohesive process for questionnaire developers of all levels. Addressing each of these steps systematically will improve the probabilities that survey designers will accurately measure what they intend to measure.

Effect of chronic renal insufficiency on outcomes of carotid endarterectomy

OBJECTIVE Conflicting data exist regarding the effect of chronic renal insufficiency (CRI) on carotid endarterectomy (CEA) outcomes. A large database was used to analyze the effect of CRI, defined by glomerular filtration rate (GFR), as an independent risk factor of CEA. METHODS Prospectively collected data regarding CEAs performed at 123 Veterans Affairs Medical Centers as part of the National Surgical Quality Improvement Program were retrospectively analyzed. Renal function was used to divide patients into three CRI groups: normal or mild (control; GFR >/=60 mL/min/1.73 m(2)), moderate (GFR 30 to 59), and severe (GFR <30). Bivariate analysis and multivariate logistic regression were used to characterize risk factors and their associations with 30-day morbidity and mortality. RESULTS Between Jan 1, 1996, and Dec 31, 2003, 22,080 patients underwent CEA. Patients missing creatinine levels, already dialysis-dependent, or in acute renal failure just before surgery were excluded. This left 20,899 available for analysis, of which 13,965 had a GFR of >/=60, 6,423 had a GFR of 30 to 59, and 511 had a GFR of <30. The incidence of neurologic complications did not differ significantly (control, 1.7%; moderate CRI, 1.9%; severe CRI, 2.7%). The moderate CRI group experienced significantly more cardiac events (1.7% vs 0.9% for controls, P < .001). This remained predictive in the multivariate model even adjusting for all other risk factors (adjusted odds ratio [AOR], 1.6; 95% confidence interval [CI], 1.1-2.3; P = .009). The moderate CRI group also had higher rates of pulmonary complications (2.1% vs 1.3% control; P < .001; AOR, 1.3; 95% CI, 1.0-1.7; P = .031) but not 30-day mortality (P = .269). Those with severe CRI had a much higher mortality (3.1% vs 1.0% control, P < .001), which remained significant in the multivariate model (AOR, 2.7; 95% CI, 1.6-4.8; P < .001). CONCLUSION Although impaired renal function does not independently increase the risk of neurologic or infectious complications, CRI is a significant negative independent risk factor in predicting other outcomes after CEA. Patients with moderate CRI (GFR, 30-59 mL/min/1.73 m(2)) are at increased risk for cardiac and pulmonary morbidity, but not death, and those with severe CRI (GFR <30 mL/min/1.73 m(2)) have a much higher operative mortality. Patients with CRI should be carefully evaluated before CEA to optimize existing cardiac and pulmonary disease. Understanding this increased risk may assist the surgeon in preoperative counseling and perioperative management.

Achievement Goal Structures and Self-Regulated Learning: Relationships and Changes in Medical School

Purpose Practicing physicians have a societal obligation to maintain their competence. Unfortunately, the self-regulated learning skills likely required for lifelong learning are not explicitly addressed in most medical schools. The authors examined how medical students’ perceptions of the learning environment relate to their self-regulated learning behaviors. They also explored how students’ perceptions and behaviors correlate with performance and change across medical school. Method The authors collected survey data from 304 students at different phases of medical school training. The survey items assessed students’ perceptions of the learning environment, as well as their metacognition, procrastination, and avoidance-of-help-seeking behaviors. The authors operationalized achievement as cumulative medical school grade point average (GPA) and, for third- and fourth-year students, collected clerkship outcomes. Results Students’ perceptions of the learning environment were associated with their metacognition, procrastination, and help-avoidance behaviors. These behaviors were also related to academic outcomes. Specifically, avoidance of help seeking was negatively correlated with cumulative medical school GPA (r = −0.23, P < .01) as well as exam (r = −0.22, P < .05) and clinical performance (r = −0.34, P < .01) in the internal medical clerkship; these help-avoidance behaviors were also positively correlated with students’ presentation at a grade adjudication committee (r = 0.20, P < .05). Additionally, students’ perceptions of the learning environment varied as a function of their phase of training. Conclusions Medical students’ perceptions of the learning environment are related, in predictable ways, to their use of self-regulated learning behaviors; these perceptions seem to change across medical school.

Effect of financial remuneration on specialty choice of fourth-year U.S. medical students.

Purpose To investigate whether financial incentives could reverse the trend of declining interest in primary care specialties among U.S. medical students. Method An electronic survey was sent to all U.S. fourth-year MD and DO medical students in 2009 with a Department of Defense service obligation. Students not selecting a primary care residency were asked if a hypothetical bonus paid before and after residency or an increase in annual salary of attendings in primary care specialties would have resulted in these students selecting primary care. Logistic regression was used to determine student characteristics associated with accepting a financial incentive. Results The survey response rate was 56% (447/797). Sixty-six percent of students did not apply for a primary care residency. Of these, 30% would have applied for primary care if they had been given a median bonus of

Letters of Recommendation: Rating, Writing, and Reading by Clerkship Directors of Internal Medicine

27,500 (interquartile range [IQR]

Medical education in the United States of America

15,000–

Lifestyle factors and primary care specialty selection: comparing 2012-2013 graduating and matriculating medical students' thoughts on specialty lifestyle.

50,000) before and after residency. Forty-one percent of students would have considered applying for primary care for a median military annual salary after residency of