Kenya Jackson
University of Michigan
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Publication
Featured researches published by Kenya Jackson.
The American Journal of Gastroenterology | 2016
Shanti L. Eswaran; William D. Chey; Theresa Han-Markey; Sarah Ball; Kenya Jackson
Objectives:There has been an increasing interest in the role of fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) in irritable bowel syndrome (IBS). We report results from the first randomized controlled trial of the low FODMAP diet in US adults with IBS and diarrhea (IBS-D). The objectives were to compare the efficacy of the low FODMAP diet vs. a diet based upon modified National Institute for Health and Care Excellence guidelines (mNICE) on overall and individual symptoms in IBS-D patients.Methods:This was a single-center, randomized-controlled trial of adult patients with IBS-D (Rome III) which compared 2 diet interventions. After a 2-week screening period, eligible patients were randomized to a low FODMAP or mNICE diet for 4 weeks. The primary end point was the proportion of patients reporting adequate relief of IBS-D symptoms ≥50% of intervention weeks 3–4. Secondary outcomes included a composite end point which required response in both abdominal pain (≥30% reduction in mean daily pain score compared with baseline) and stool consistency (decrease in mean daily Bristol Stool Form of ≥1 compared with baseline), abdominal pain and stool consistency responders, and other key individual IBS symptoms assessed using daily questionnaires.Results:After screening, 92 subjects (65 women, median age 42.6 years) were randomized. Eighty-four patients completed the study (45 low FODMAP, 39 mNICE). Baseline demographics, symptom severity, and nutrient intake were similar between groups. Fifty-two percent of the low FODMAP vs. 41% of the mNICE group reported adequate relief of their IBS-D symptoms (P=0.31). Though there was no significant difference in the proportion of composite end point responders (P=0.13), the low FODMAP diet resulted in a higher proportion of abdominal pain responders compared with the mNICE group (51% vs. 23%, P=0.008). Compared with baseline scores, the low FODMAP diet led to greater reductions in average daily scores of abdominal pain, bloating, consistency, frequency, and urgency than the mNICE diet.Conclusions:In this US trial, 40–50% of patients reported adequate relief of their IBS-D symptoms with the low FODMAP diet or a diet based on modified NICE guidelines. The low FODMAP diet led to significantly greater improvement in individual IBS symptoms, particularly pain and bloating, compared with the mNICE diet.
Clinical Gastroenterology and Hepatology | 2017
Shanti L. Eswaran; William D. Chey; Kenya Jackson; Sivaram Pillai; Samuel W. Chey; Theresa Han-Markey
BACKGROUND & AIMS: We investigated the effects of a diet low in fermentable oligo‐, di‐, and monosaccharides and polyols (FODMAPs) vs traditional dietary recommendations on health‐related quality of life (QOL), anxiety and depression, work productivity, and sleep quality in patients with irritable bowel syndrome and diarrhea (IBS‐D). METHODS: We conducted a prospective, single‐center, single‐blind trial of 92 adult patients with IBS‐D (65 women; median age, 42.6 years) randomly assigned to groups placed on a diet low in FODMAPs or a modified diet recommended by the National Institute for Health and Care Excellence (mNICE) for 4 weeks. IBS‐associated QOL (IBS‐QOL), psychosocial distress (based on the Hospital Anxiety and Depression Scale), work productivity (based on the Work Productivity and Activity Impairment), and sleep quality were assessed before and after diet periods. RESULTS: Eighty‐four patients completed the study (45 in the low‐FODMAP group and 39 in the mNICE group). At 4 weeks, patients on the diet low in FODMAPs had a larger mean increase in IBS‐QOL score than did patients on the mNICE diet (15.0 vs 5.0; 95% CI, –17.4 to –4.3). A significantly higher proportion of patients in the low‐FODMAP diet group had a meaningful clinical response, based on IBS‐QOL score, than in the mNICE group (52% vs 21%; 95% CI, –0.52 to –0.08). Anxiety scores decreased in the low‐FODMAP diet group compared with the mNICE group (95% CI, 0.46–2.80). Activity impairment was significantly reduced with the low‐FODMAP diet (–22.89) compared with the mNICE diet (–9.44; 95% CI, 2.72–24.20). CONCLUSIONS: In a randomized, controlled trial, a diet low in FODMAPs led to significantly greater improvements in health‐related QOL, anxiety, and activity impairment compared with a diet based on traditional recommendations for patients with IBS‐D. ClinicalTrials.gov, number NCT01624610.
Gastroenterology | 2016
Shanti L. Eswaran; William D. Chey; Kenya Jackson; Sivaram Pillai; Samuel W. Chey; Theresa Han-Markey
Background: In addition to characteristic GI symptoms, irritable bowel syndrome (IBS) patients have incraesed psychological comorbidity and sleep disturbance as well as reduced health-related quality of life (HRQOL), and work productivity relative to the general population. We assessed the impact of a low FODMAP diet versus a control diet on HRQOL, psychological distress, work productivity, and sleep quality measures in patients with IBS and diarrhea (IBS-D). Methods: We conducted a prospective, single center, single-blind randomized controlled trial of adult patients with IBS-D (Rome III). After completing a 2week screening period, eligible patients (mean daily abdominal pain score ≥4 & Bristol stool scale score of ≥5) were randomized to 4-weeks of a low FODMAP diet (LFD) or a control diet based upon modified NICE guidelines. Foods containing FODMAPs were not specifically excluded from the control diet. Both dietary interventions were administered by experienced research dietitians. HRQOL (IBS-QOL), psychosocial distress (Hospital Anxiety and Depression Scale (HADS)), work productivity (Workplace Activity Impairment (WPAI)), and an assessment of sleep quality were conducted before and after the dietary intervention. Fatigue and sleep quality were assessed daily over the study period. Results: Of the 171 subjects consented for enrollment, 92 (65 women (71%), median age 42.6 years (range = 19 -75 years), 68 Caucasian (74%)) were eligible for randomization based upon the baseline assessment. Eighty-three patients completed the study period (45 LFD, 38 control). Demographics, baseline symptom severity, and baseline HRQOL measures were similar between groups. Baseline energy, nutrient, and FODMAP intake were similar between groups. At 4 weeks, the proportion of patients with a >10-point improvement in IBS-QOL score was significantly greater in the LFD group compared to the control group (58% v 24%, p=0.0032). Similarly, the mean total IBS-QOL score at 4 weeks was higher in the LFD v control (p=.0228). Significant improvements were observed in several IBS-QOL domains ( Table 1). There was a trend towards improvement in anxiety for the LFD vs. the control diet which did not reach statistical significance (7.73 v 9.26, p=0.0679). For WPAI, only activity impairment significantly improved (LFD 29.29 v control 41.90, p=0.0398). There was no difference between the two groups for fatigue but sleep quality improved in the LFD compared to the control diet (6.33 v 7.46, p=0.0336). Conclusion: In this US randomized, controlled study of IBS-D patients, a low FODMAP diet improved HRQOL, activity impairment, and sleep quality when compared to a control diet. This is one of the first methodologically rigorous clinical trials to show that diet-based therapy can not only improve symptoms but also HRQOL in patients with IBS-D. Table. IBS QOL means after dietary intervention.
Gastroenterology | 2017
Shanti L. Eswaran; Juanita L. Merchant; Amanda Photenhauer; Kenya Jackson; Dennis Madriaga; Fabiyola Selvaraj; Fred Princen; William D. Chey
Gastroenterology | 2016
Juanita L. Merchant; Amanda Photenhauer; Shanti L. Eswaran; Kenya Jackson; William D. Chey
Gastroenterology | 2017
Shanti L. Eswaran; William D. Chey; Kenya Jackson; Theresa Han-Markey
Gastroenterology | 2017
Stacy B. Menees; Kenya Jackson; Xiao Xu; Dee E. Fenner
Digestive Diseases and Sciences | 2017
Jennifer K. Maratt; Joseph Dickens; Philip Schoenfeld; Grace H. Elta; Kenya Jackson; Daniel Rizk; Christine Erickson; Stacy B. Menees
Gastrointestinal Endoscopy | 2016
Jennifer K. Maratt; Philip Schoenfeld; Grace H. Elta; Kenya Jackson; Daniel Rizk; Christine Jakubiec; Stacy B. Menees
Gastroenterology | 2016
Shanti L. Eswaran; William D. Chey; Kenya Jackson; Sarah Ball; Theresa Han-Markey