Kerry Taylor
Heidelberg University
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Publication
Featured researches published by Kerry Taylor.
Pediatric Infectious Disease Journal | 1993
Robyn Rodwell; Kerry Taylor; David Tudehope; Peter H. Gray
The hematologic profiles of 1000 newborns were prospectively examined to identify infants with neutropenia (N = 170) according to the system of Manroe et al. (J Pediatr 1979;95:89-98) and to evaluate a hematologic scoring system (Rodwell et al. J Pediatr 1988;112:761-7) as a screening test for sepsis. Neutropenia was more commonly of noninfectious than infectious origin (83.5% vs. 16.5%; P < 0.001). On the initial test a positive screen (scores > or = 3) identified 26 of 28 infants with sepsis or probable infection (sensitivity 93%; specificity 82%; positive and negative predictive values 50 and 98%, respectively). Corresponding values for an elevated immature:total neutrophil ratio were 100, 75, 43 and 100%. Overall mortality with neutropenia was 15% and was higher with an infectious than a noninfectious etiology (39% vs. 11%, P < 0.001) despite early antibiotic therapy. The combination of a neutrophil count < or = 500/mm3 and scores > or = 3 or an elevated immature:total neutrophil ratio identified a poor prognostic group: 67% (8 of 12) and 70% (7 of 10) infants, respectively, with these findings died, 6 in the infected group. The hematologic scoring system or immature:total neutrophil ratio in combination with the degree of neutropenia provides valuable diagnostic and prognostic information which could be applied to identification of possible candidates for granulocyte transfusions or other experimental treatments.
Archives of Disease in Childhood-fetal and Neonatal Edition | 1996
Robyn Rodwell; Peter H. Gray; Kerry Taylor; R Minchinton
Granulocyte colony stimulating factor (G-CSF) treatment was successfully used in three preterm infants with alloimmune neonatal neutropenia (AINN). Two infants had persistent neutropenia despite treatment with intravenous immunoglobulin and random donor granulocyte transfusions for presumed sepsis. Neutrophil counts returned to normal with G-CSF treatment; the response was least convincing in one infant with fulminant necrotising enterocolits. It is suggested that treatment with G-CSF be considered early for the treatment of infants with AINN.
Pathology | 1993
Debra L. Taylor; Anne-Marie Kerwick; Suzanne L. Elliott; Robyn Rodwell; S. Wright; Paula Marlton; Kerry Taylor; Anne R. Veleba
&NA; Decreased neutrophil alkaline phosphatase (NAP) synthesis is a classical feature of Philadelphia (Ph) positive chronic phase chronic myeloid leukemia (CML). Whether this aberration is an integral leukemic property of the cell or results from mediation by other factors is unclear. During α‐interferon (α‐IFN) based therapy the relationship between Ph chromosome suppression and NAP synthesis was examined. Four categories of response were observed in 19 patients studied sequentially. Significantly, persistent low NAP activity was observed in one patient in complete cytogenetic remission, while a second group of 7 patients demonstrated normal NAP activity in spite of persistence of the Ph chromosome in 100% of metaphases. In the absence of various clinical influences that can modulate NAP activity in chronic phase CML, the results reinforce the observation that the BCWABL fusion gene product is not a key factor influencing NAP activity in CML.
Leukemia & Lymphoma | 1993
Kerry Taylor; Robyn Rodwell; Suzanne L. Elliott; Debra L. Taylor
X-linked clonal analysis (XLCA) either using Glucose-6-phosphate dehydrogenase (G-6-P-D) polymorphisms or restriction fragment length polymorphisms (RFLP) and methylation analysis has provided considerable understanding of haematologic malignancy. Acute Promyelocytic Leukemia (APL) is characterized by a unique cytogenetic translocation t(15;17), frequent achievement of remission without a preceding phase of marrow hypocellularity after induction chemotherapy and a high rate of clinical response to all-trans retinoic acid (ATRA). In limited studies XLCA has provided insight into the pathogenesis and mechanism of drug action in this disease.
Blood | 2001
Asuman Demiroglu; E. Joanna Steer; Carol Heath; Kerry Taylor; Mark Bentley; Steven L. Allen; Prasad Koduru; Judith Brody; Geoffrey Hawson; Robyn Rodwell; Mary Lou. Doody; Fernando Carnicero; Andreas Reiter; John M. Goldman; Junia V. Melo; Nicholas C.P. Cross
Blood | 1992
Suzanne L. Elliott; Kerry Taylor; S White; Robyn Rodwell; Paula Marlton; D Meagher; J Wiley; D Taylor; S. Wright; P Timms
Blood | 1996
Po Iversen; Robyn Rodwell; L Pitcher; Kerry Taylor; Af Lopez
Pathology | 1993
S. Wright; Anne-Marie Kerwick; Robyn Rodwell; Kerry Taylor
Pathology | 2017
Kais Kasem; Blake O'Brien; Kerry Taylor
Archive | 2013
Kerry Taylor; Devinder Gill; Paula Marlton; Ken Bradstock; Katrina Williams; Cathryn Kelly; Penny Stravos; Robyn Rodwell; Geoff Hill; Susan Wright; Slavica Vuckovic; Min Kim; Cameron J. Turtle; Georgina Crosbie; Noel Williams