Kevin Fung
University of Southern California
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Science | 1996
Jeff Linnen; John Wages; Zhen-Yong Zhang-Keck; Kirk E. Fry; Krzysztof Krawczynski; Harvey J. Alter; Eugene V. Koonin; Margaret Gallagher; Miriam J. Alter; Stephanos J. Hadziyannis; Peter Karayiannis; Kevin Fung; Yoshiyuki Nakatsuji; J. Wai‐Kuo Shih; Lavonne Young; Michael Piatak; Cameron Hoover; John Fernandez; Stacie Chen; Jian-Chao Zou; Timothy T. Morris; Kenneth C. Hyams; S. Ismay; Jeffrey D. Lifson; Georg Hess; Steven K. H. Foung; Howard C. Thomas; Daniel G. Bradley; Harold S. Margolis; Jungsuh P. Kim
An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.
Journal of Chromatography B: Biomedical Sciences and Applications | 1998
C. Patrick McAtee; Moon Young Lim; Kevin Fung; Mark Douglas Velligan; Kirk E. Fry; Theresa P. Chow; Douglas E. Berg
In a previous two-dimensional (2D) gel electrophoretic study of protein antigens of the gastric pathogen, Helicobacter pylori recognized by human sera, one of the highly and consistently reactive antigens, a protein with Mr of approximately 30,000 (Spot 15) seemed to be of special interest because of low yields on N-terminal protein sequencing. This suggested possible N-terminal modification, as the N-terminal sequence analysis of this 30,000 protein (Spot 15) did not provide a definitive match within the H. pylori genomic database. This protein was isolated by 2D polyacrylamide gel electrophoresis, evaluated by liquid chromatography-mass spectrometry, and found to consist of two related species of approximately 28,100 and 26,500. In parallel, the proteins within this spot were digested in situ with the endoprotease Lys-C. Analysis of the Lys-C digest by matrix-assisted laser desorption time-of-flight mass spectrometry, peptide mapping, and sequence analysis was conducted. Comparison of the mass and sequence of the Lys-C peptides with those derived from a H. pylori genomic library identified an open reading frame of approximately 300 base pairs as the source of the Spot 15 protein. This corresponded to HP0175 in the recently reported H. pylori genome sequence, an open reading frame with some homology to Campylobacter jejeuni cell binding protein 2. Mass spectral and sequence analysis indicated that Spot 15 was a processed product generated by proteolytic cleavage at both the carboxy and amino termini of the 34 open reading frame precursor.
Clinical and Vaccine Immunology | 1998
C. Patrick McAtee; Moon Young Lim; Kevin Fung; Mark Douglas Velligan; Kirk E. Fry; Theresa P. Chow; Douglas E. Berg
Journal of Medicinal Chemistry | 2002
Natalia B. Dyatkina; Christopher Don Roberts; Jesse Keicher; Yuqin Dai; Joshua P. Nadherny; Wentao Zhang; Uli Schmitz; Ana Kongpachith; Kevin Fung; Alexander Novikov; Lillian Lou; Mark Douglas Velligan; and Alexander A. Khorlin; Ming S. Chen
Nucleic acids symposium series (2004) | 2008
Marija Prhavc; Natalia B. Dyatkina; Jesse D. Keicher; Sebastian Johannes Reinhard Liehr; Samantha Koo-McCoy; Derek Latour; Kevin Fung; Kevin Dunlop; Jeffrey J. Pouliot; Ting Wang; Wenbao Li; Lillian Lou; Christopher Don Roberts; Ronald Conrad Griffith
Hepatology | 2003
Derek Latour; Kevin Fung; Emil Michelotti; Jeffrey Pouliot; Lillian Lou; Martin D. Kirk
Collection of Czechoslovak Chemical Communications | 2008
Natalia B. Dyatkina; Marija Prhavc; Jesse Keicher; Sebastian Johannes Reinhard Liehr; Samantha Koo-McCoy; Derek Latour; Kevin Fung; Jeff Pouliot; Ting Wang; Wenbao Li; Lillian Lou; Christopher Don Roberts; Ron Griffith
Antiviral Research | 2009
Christopher Don Roberts; Jesse D. Keicher; Samantha Koo-McCoy; Derek Latour; Jeffrey Pouliot; Kevin Fung; John Zhang; Mohan Sivaraja; Mark Cunningham; Jill Bechtel; Lillian Lou; Natalia B. Dyatkina; Ting Wang; Wenbao Li; Amy K. Patick; Ronald Conrad Griffith
Antiviral Research | 2009
Jesse D. Keicher; Natalia B. Dyatkina; Xiaoling Zheng; Vivek K. Rajwanshi; Marija Prhavc; Samantha Koo-McCoy; Kevin Fung; Derek Latour; Mohan Sivaraja; Uli Schmitz; Christopher Don Roberts; Ronald Conrad Griffith
Collection of Czechoslovak Chemical Communications | 2008
Jesse Keicher; Natalia B. Dyatkina; Samantha Koo-McCoy; Derek Latour; Kevin Fung; Jeff Pouliot; Ting Wang; Hong Luo; Wenbao Li; Lillian Lou; Christopher Don Roberts; Ron Griffith