Kevin L. Ard

Addressing intimate partner violence in lesbian, gay, bisexual, and transgender patients.

The medical community’s efforts to address intimate partner violence (IPV) have often neglected members of the lesbian, gay, bisexual, and transgender (LGBT) population. Heterosexual women are primarily targeted for IPV screening and intervention despite the similar prevalence of IPV in LGBT individuals and its detrimental health effects. Here, we highlight the burden of IPV in LGBT relationships, discuss how LGBT and heterosexual IPV differ, and outline steps clinicians can take to address IPV in their LGBT patients.

Health Outcomes of Obtaining Housing Among Older Homeless Adults

OBJECTIVES We determined the impact of obtaining housing on geriatric conditions and acute care utilization among older homeless adults. METHODS We conducted a 12-month prospective cohort study of 250 older homeless adults recruited from shelters in Boston, Massachusetts, between January and June 2010. We determined housing status at follow-up, determined number of emergency department visits and hospitalizations over 12 months, and examined 4 measures of geriatric conditions at baseline and 12 months. Using multivariable regression models, we evaluated the association between obtaining housing and our outcomes of interest. RESULTS At 12-month follow-up, 41% of participants had obtained housing. Compared with participants who remained homeless, those with housing had fewer depressive symptoms. Other measures of health status did not differ by housing status. Participants who obtained housing had a lower rate of acute care use, with an adjusted annualized rate of acute care visits of 2.5 per year among participants who obtained housing and 5.3 per year among participants who remained homeless. CONCLUSIONS Older homeless adults who obtained housing experienced improved depressive symptoms and reduced acute care utilization compared with those who remained homeless.

HIV-associated Neurocognitive Disorders and Antiretroviral Therapy: Current Concepts and Controversies

Antiretroviral drugs may help prevent neurological decline in individuals with HIV infection by suppressing viral replication and associated chronic immune activation in the central nervous system. However, HIV control in the brain may come at the price of drug-induced neurotoxicity. Herein, we review recent advances in the balance between adequate viral suppression in the nervous system and adverse effects of the medications used in HIV treatment.

Advancing health equity for lesbian, gay, bisexual and transgender (LGBT) people through sexual health education and LGBT-affirming health care environments

Lesbian, gay, bisexual and transgender (LGBT) people face pervasive health disparities and barriers to high-quality care. Adequate LGBT sexual health education for emerging health professionals is currently lacking. Clinical training programs and healthcare organisations are well poised to start addressing these disparities and affirming LGBT patients through curricula designed to cultivate core competencies in LBGT health as well as health care environments that welcome, include and protect LGBT patients, students and staff. Health education programs can emphasise mastery of basic LGBT concepts and terminology, as well as openness towards and acceptance of LGBT people. Core concepts, language and positive attitudes can be instilled alongside clinical skill in delivering inclusive sexual health care, through novel educational strategies and paradigms for clinical implementation. Caring for the health needs of LGBT patients also involves the creation of health care settings that affirm LGBT communities in a manner that is responsive to culturally specific needs, sensitivities and challenges that vary across the globe.

Peritoneal Tuberculosis in a Pregnant Woman from Haiti, United States

To the Editor: A 29-year-old woman at 23 weeks’ gestation during her first pregnancy came to our hospital’s obstetrics clinic after 6 days of vaginal bleeding and abdominal pain. She had not experienced fever, sweats, weight loss, contractions, or other symptoms. She was otherwise healthy; she was taking no medications, but was taking iron and multivitamin supplements. She had legally immigrated to the United States from Haiti 8 months previously and had no known tuberculosis contacts. Physical examination disclosed brown vaginal discharge and a closed cervix. Obstetric ultrasound was normal, and vaginal swab samples were negative for Neisseria gonorrhea and Chlamydia trachomatis. Over the ensuing 2 weeks, her vaginal bleeding and abdominal pain worsened. She was admitted to the hospital. Physical examination revealed vaginal bleeding, but her condition was otherwise unchanged. Routine laboratory studies were normal. Repeat obstetric ultrasound showed a viable fetus, ascites, and a 15 × 15 × 3–cm rind of echogenic material anterior to the uterus. This abnormality was in the upper abdomen, an area not imaged on her previous ultrasound. Abdominal magnetic resonance imaging revealed moderate ascites and a 21 × 14 × 3–cm omental mass of intermediate intensity on T1 and T2 sequences; there was no lymphadenopathy (Figure). A tiny left pleural effusion was seen on chest radiograph. Routine HIV and tuberculin skin test results had been negative 4 months previously, and pre-immigration examination results and chest radiograph had been normal. Figure T2-weighted magnetic resonance imaging sequence of the abdomen of a pregnant woman from Haiti. An omental mass of intermediate intensity (white arrow) is shown anterior to the uterus. Fine-needle aspiration of the omental mass was nondiagnostic. The patient’s vaginal bleeding and abdominal pain persisted, and her cervix dilated. She had an oral temperature of 38.9° Celsius. Exploratory laparotomy demonstrated a friable omental mass with implants on the small bowel; a partial omentectomy was performed at 26 weeks’ gestation. During this procedure, the patient gave birth to a male infant. Multiple granulomata, some containing acid-fast bacilli, were identified upon histologic examination of the momentum (Technical Appendix Figure). Transcription-mediated amplification of the specimen was positive for Mycobacterium tuberculosis rRNA; cultures later grew M. tuberculosis susceptible to all first-line antituberculosis medications. Sputum smears and cultures were not performed. The patient’s treatment began with isoniazid, rifampin, ethambutol, and pyrazinamide; her fevers and abdominal pain resolved. Her son was admitted to the neonatal intensive care unit and was placed on antimycobacterial therapy. He also recovered and was discharged after 135 days. This case highlights several issues related to tuberculosis epidemiology and diagnosis. Although pulmonary disease is the most common manifestation of tuberculosis overall, extrapulmonary tuberculosis accounts for a significant and increasing proportion of cases in the United States (1). Pregnancy is associated with greater likelihood of extrapulmonary disease; extrapulmonary infection accounts for 13% of all cases worldwide (2) but 50% of cases in pregnancy, according to a recent study (3). The frequency of peritoneal tuberculosis in pregnancy is unknown; few cases have been reported in the literature (4–7), although we know of 3 additional cases from Haiti (online Technical Appendix Table). However, cases are likely underdiagnosed or diagnosed late in the course of illness. Underdiagnosis and delayed diagnosis may be caused by the nonspecific nature of symptoms, commonly abdominal pain and ascites, which can be attributed to pregnancy itself or obstetrical complications. These erroneous explanations for symptoms are reflected in this patient, whose symptoms were initially attributed to abruption and who was not diagnosed with tuberculosis until >3 weeks after seeking medical assistance. Such delays in diagnosis are typical of peritoneal tuberculosis and are associated with increased death rates (8). In many cases, clinical features cannot distinguish peritoneal tuberculosis from malignancy, necessitating more extensive evaluation (7). Failure to diagnose peritoneal tuberculosis, in pregnancy or otherwise, might also stem from the insensitivity of noninvasive diagnostic testing. Paracentesis with acid-fast staining detects only a minority of cases (8). The sensitivity of mycobacterial cultures of ascites fluid varies, and culture results are often not available for weeks (8). Ascites fluid adenosine deaminase has shown promise as a reliable, minimally invasive diagnostic test in resource-poor countries, but was insensitive in a United States study (9). In addition, although tuberculin skin testing and interferon gamma release assay performance are not affected by pregnancy (10), neither can distinguish active from latent infection. Without diagnostic clinical features or sensitive noninvasive tests, the diagnosis of peritoneal tuberculosis might only be confirmed through laparoscopy or laparotomy, as in our case. Such invasive testing methods and facilities, equipment, and personnel might not be readily available in resource-poor settings. This case also illustrates the ongoing threat of tuberculosis in countries of all income levels. It is not clear where our patient contracted tuberculosis; she was most likely exposed in Haiti, but transmission within her Haitian community in the United States, or from another source, is also possible. Regardless, as in her case, a majority of tuberculosis cases within the United States occur in foreign-born persons. Given the ease and frequency of travel, lapses in tuberculosis control in any locale are likely to have effects more broadly. Wherever they work, clinicians must maintain vigilance for tuberculosis in all of its protean forms. Technical Appendix: Case characteristics of peritoneal tuberculosis in pregnancy and diagnostic image. Click here to view.(166K, pdf)

Conflicting effects of atazanavir therapy on atherosclerotic risk factors in stable HIV patients: A randomized trial of regimen switch to atazanavir

Bilirubin acts as a potent endogenous antioxidant, with higher concentrations associated with lower rates of CVD; the antiretroviral drug atazanavir (ATV) increases bilirubin levels but may also increase von Willebrand factor levels. We tested the hypothesis that increasing endogenous bilirubin using ATV would improve cardiometabolic risk factors and vascular function in older patients with HIV. Ninety participants were enrolled in two study protocols. In protocol 1, we evaluated markers of inflammation, thrombosis, and conduit artery endothelial function in subjects on non-ATV containing regimens. Participants were randomly assigned to continue baseline treatment or switch to an ATV-based regimen. Measurements were made at baseline and 28 days. In the protocol 2, we enrolled 30 subjects who received atazanavir for more than one year and were compared to the aim 1 protocol subjects at baseline. 60 subjects were enrolled in the first protocol (mean age 53, +/- 6 years), with 31 randomized to ATV and 29 continuing baseline treatment. Atazanavir significantly increased serum total bilirubin levels (p<0.001) and acutely but not chronically plasma total antioxidant capacity (p<0.001). An increase in von Willebrand Factor (p<0.001) and reduction in hs-CRP (p = 0.034) were noted. No changes were seen in either flow-mediated endothelium-dependent or vasodilation. In cross-sectional analysis (second protocol), similar findings were seen in the baseline attributes of non-atazanavir-based and long-term atazanavir users. Increasing serum bilirubin levels with atazanavir in subjects with HIV reduces hs-CRP, temporarily reduces oxidative stress, but increases von Willebrand Factor. Atazanavir does not improve endothelial function of conduit arteries. Trial registration: ClinicalTrials.gov NCT03019783.

Case 9-2018: A 55-Year-Old Man with HIV Infection and a Mass on the Right Side of the Face

A Man with HIV Infection and a Facial Mass A 55-year-old man with HIV infection and a CD4+ T-cell count of 65 per cubic millimeter presented to the hospital 1 week after he started antiretroviral therapy because of a rapidly enlarging mass at the angle of the right mandible. A diagnostic procedure was performed.

Outcomes According to Discharge Location for Persons Who Inject Drugs Receiving Outpatient Parenteral Antimicrobial Therapy

Abstract Background Opioid use disorder poses a significant public health risk. Persons who inject drugs (PWID) suffer from high mortality and morbidity secondary to serious infectious diseases, often requiring prolonged courses of outpatient parenteral antibiotics. The goal of this study was to determine the outcomes of PWID discharged to home or to a skilled nursing or rehabilitation facility (SNF/rehab) with parenteral antibiotic treatment under an outpatient parenteral antimicrobial therapy (OPAT) program. Methods This is a retrospective observational study. The study population was identified via hospital and OPAT databases using substance use disorder diagnoses and confirmed through chart review. The study population included hospitalized PWID with injection drug use in the preceding 2 years who were discharged between 2010 and 2015 to complete at least 2 weeks of parenteral antibiotics and monitored by the OPAT program. Retrospective chart review was used to describe patient characteristics and outcomes. Results Fifty-two patients met inclusion criteria, 21 of whom were discharged to home and 31 were discharged to a SNF/rehab. Of the patients discharged to home, 17 (81%) completed their planned antibiotic courses without complication. Twenty (64%) patients discharged to a SNF/rehab completed the antibiotic courses without complication. Six (11%) patients had line infections, 6 (11%) had injection drug use relapse, and 12 (23%) required readmission. Conclusions Persons who inject drugs discharged home were not more likely to have complications than those discharged to a SNF/rehab. Home OPAT may be a safe discharge option in carefully selected patients.

Cancer in People Living With HIV, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology

People living with HIV (PLWH) are diagnosed with cancer at an increased rate over the general population and generally have a higher mortality due to delayed diagnoses, advanced cancer stage, comorbidities, immunosuppression, and cancer treatment disparities. Lack of guidelines and provider education has led to substandard cancer care being offered to PLWH. To fill that gap, the NCCN Guidelines for Cancer in PLWH were developed; they provide treatment recommendations for PLWH who develop non-small cell lung cancer, anal cancer, Hodgkin lymphoma, and cervical cancer. In addition, the NCCN Guidelines outline advice regarding HIV management during cancer therapy; drug-drug interactions between antiretroviral treatments and cancer therapies; and workup, radiation therapy, surgical management, and supportive care in PLWH who have cancer.

Public Health Detailing for Human Immunodeficiency Virus Pre-exposure Prophylaxis

Despite the promise of human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP), PrEP remains underutilized, often due to clinician factors. Academic or public health detailing is a process by which university and/or government groups employ the marketing practices of pharmaceutical companies to improve clinical practice. We describe the novel application of detailing to increase PrEP prescribing and related care in New York City and New England. Detailing can play a crucial role in PrEP implementation.