Kevin Ralston

Self‐Assembly of Disorazole C1 through a One‐Pot Alkyne Metathesis Homodimerization Strategy

Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C2-symmetric marine-derived bis(lactone) disorazole C1, a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.

A comparison of the Scottish Index of Multiple Deprivation (SIMD) 2004 with the 2009 + 1 SIMD: does choice of measure affect the interpretation of inequality in mortality?

BackgroundThere is a growing international literature assessing inequalities in health and mortality by area based measures. However, there are few works comparing measures available to inform research design. The analysis here seeks to begin to address this issue by assessing whether there are important differences in the relationship between deprivation and inequalities in mortality when measures that have been constructed at different time points are compared.MethodsWe contrast whether the interpretation of inequalities in all-cause mortality between the years 2008-10 changes in Scotland if we apply the earliest (2004) and the 2009 + 1 releases of the Scottish Index of Multiple Deprivation (SIMD) to make this comparison. The 2004 release is based on data from 2001/2 and the 2009 + 1 release is based on data from 2008/9. The slope index of inequality (SII) and 1:10 ratio are used to summarise inequalities standardised by age/sex using population and mortality records.ResultsThe 1:10 ratio suggests some differences in the magnitude of inequalities measured using SIMD at different time points. However, the SII shows much closer correspondence.ConclusionsOverall the findings show that substantive conclusions in relation to inequalities in all-cause mortality are little changed by the updated measure. This information is beneficial to researchers as the most recent measures are not always available. This adds to the body of literature showing stability in inequalities in health and mortality by geographical deprivation over time.

Patterns of mortality by occupation in the UK, 1991–2011: a comparative analysis of linked census and mortality records

Summary Background Detailed assessments of mortality by occupation are scarce. We aimed to assess mortality by occupation in the UK, differences in rates between England and Wales and Scotland, and changes over time in Scotland. Methods We analysed adults of working age (20–59 years) using linked census and death records. Main occupation was coded into more than 60 groups in the 2001 census, with mortality follow-up until Dec 31, 2011. Comparable occupation data were available for Scotland in 1991, allowing assessment of trends over time. We calculated age-standardised all-cause mortality rates (per 100 000 person-years), stratified by sex. We used Monte Carlo simulation to derive p values and 95% CIs for the difference in mortality over time and between England and Wales and Scotland. Findings During 4·51 million person-years of follow-up, mortality rates by occupation differed by more than three times between the lowest and highest observed rates in both men and women. Among men in England and Wales, health professionals had the lowest mortality (225 deaths per 100 000 person-years [95% CI 145–304]), with low rates also shown in managers and teachers. The highest mortality rates were in elementary construction (701 deaths per 100 000 person-years [95% CI 593–809]), and housekeeping and factory workers. Among women, teachers and business professionals had low mortality, and factory workers and garment trade workers had high rates. Mortality rates have generally fallen, but have stagnated or even increased among women in some occupations, such as cleaners (337 deaths per 100 000 person years [95% CI 292–382] in 1991, rising to 426 deaths per 100 000 person years in 2001 [371–481]). Findings from simulation models suggested that if mortality rates by occupation in England and Wales applied to Scotland, 631 fewer men (95% CI 285–979; a 9·7% decrease) and 273 fewer women (26–513; 6·7% decrease) of working age would die in Scotland every year. Excess deaths in Scotland were concentrated among lower skilled occupations (eg, female cleaners). Interpretation Mortality rates differ greatly by occupation. The excess mortality in Scotland is concentrated among low-skilled workers and, although mortality has improved in men and women in most occupational groups, some groups have experienced increased rates. Future research investigating the specific causes of death at the detailed occupational level will be valuable, particularly with a view to understanding the health implications of precarious employment and the need to improve working conditions in very specific occupational groups. Funding None.

Do young people not in education, employment or training experience long-term occupational scarring? A longitudinal analysis over 20 years of follow-up

Not in education, employment or training (NEET) is a contested concept in the literature. However, it is consistently used by policy-makers and shown in research to be associated with negative outcomes. In this paper we examine whether NEET status is associated with subsequent occupational scarring using the Scottish Longitudinal Study which provides a 5.3% sample of Scotland, based on the censuses of 1991, 2001 and 2011. We model occupational position, using CAMSIS, controlling for the influence of sex, limiting long-term illness, educational attainment and geographical deprivation. We find the NEET categorisation to be a strong marker of subsequent negative outcomes at the aggregate level. This appears to be redolent of a Matthew effect, whereby disadvantage accumulates to the already disadvantaged. Our results also show that negative NEET effects are variable when stratifying by educational attainment and are different for men and women. These findings confirm that there are negative effects on occupational position associated with prior NEET status but that outcomes are heterogeneous depending on levels of education and gender.

Do differences in religious affiliation explain high levels of excess mortality in the UK

Background High levels of mortality not explained by differences in socioeconomic status (SES) have been observed for Scotland and its largest city, Glasgow, compared with elsewhere in the UK. Previous cross-sectional research highlighted potentially relevant differences in social capital, including religious social capital (the benefits of social participation in organised religion). The aim of this study was to use longitudinal data to assess whether religious affiliation (as measured in UK censuses) attenuated the high levels of Scottish excess mortality. Methods The study used the Scottish Longitudinal Study (SLS) and the ONS Longitudinal Study of England and Wales. Risk of all-cause mortality (2001–2010) was compared between residents aged 35 and 74 years of Scotland and England and Wales, and between Glasgow and Liverpool/Manchester, using Poisson regression. Models adjusted for age, gender, SES and religious affiliation. Similar country-based analyses were undertaken for suicide. Results After adjustment for age, gender and SES, all-cause mortality was 9% higher in Scotland than in England and Wales, and 27% higher in Glasgow than in Liverpool or Manchester. Religious affiliation was notably lower across Scotland; but, its inclusion in the models did not attenuate the level of Scottish excess all-cause mortality, and only marginally lowered the differences in risk of suicide. Conclusions Differences in religious affiliation do not explain the higher mortality rates in Scotland compared with the rest of the UK. However, it is possible that other aspects of religion such as religiosity or religious participation which were not assessed here may still be important.

OP31 Is Excess Mortality in Glasgow an Artefact of Inadequate Control for Deprivation: A Case-Control Study

Background Scotland experiences higher mortality than the rest of Western Europe with Glasgow experiencing higher mortality than the rest of Scotland. This excess persists even when controlling for socio-economic status and levels of deprivation. Moreover, available measures of deprivation have accounted for less of the Glasgow excess over last 30 years. Many theories have been put forward to account for these differences and a recent review identified seventeen hypotheses. One hypothesis, investigated here, was an artefact of inadequate control for deprivation. Methods Previous analyses of Glasgow’s ‘excess’ within Scotland have been based on comparison with nationally derived deprivation groupings (e.g. quintiles, deciles). Glasgow’s unique deprivation profile in comparison to the rest of Scotland renders such approaches problematic. Our approach, therefore, is as follows: small area geographies (datazones) were ranked by the Scottish Index of Multiple Deprivation (SIMD) income domain. Using a case control design datazones in Glasgow (cases) were matched with the closest non Glasgow datazone ranked above and below (controls). Geocoded mortality and population data were available for all deaths by age and sex for 2000-2002. Age-standardised all-cause mortality rates were calculated for men and women between the ages of 0–64, and for all ages. Age-standardised mortality rates by sex were compared for cases and matched controls for each quintile of deprivation. Results Men in the 3 most deprived quintiles in Glasgow experienced higher levels of mortality compared to both the nearest non-Glasgow datazones and all non-Glasgow datazones within the quintile. Excess mortality was reduced for the 2 most affluent quintiles. The pattern was broadly similar for women, with the excess reduced for the 3 most affluent quintiles. The age-standardised mean mortality rate for men aged 0–64 in Glasgow in the most deprived quintile was 769 per 100,000. The corresponding rate for all non-Glasgow datazones was 582 per 100,000. The mortality rate for the control group was 688 per 100,000, suggesting a substantially smaller excess. Using this case-control approach, the excess is reduced by 57% in the most deprived quintile. In the second most deprived quintile it is reduced by 15%. The corresponding results for women are reductions of 57% (most deprived quintile) and 47% (second most deprived quintile). Conclusion Using national population and mortality data, the excess mortality in Glasgow in the most deprived area is halved by means of a closer control for deprivation. Explanations are still required for the remaining excess suggesting it is only partly artefactual.

Gender, Occupation and First Birth: Do ‘Career Men’ Delay First Birth Too?

In the period following the turn of the Century European total fertility rates (TFR) dropped to well below replacement. Work examining this highlights that cohort postponement in births contributes to low TFRs. It is generally recognised that women in more advantaged occupations often postpone childbearing in contrast to those in less advantaged occupational groups. However, relatively little research has been conducted on men in similar terms. This paper contrasts the timing of first birth by occupational class between men and women using individual level data in a case study of Scotland. The data are an extract from the Scottish Longitudinal Study (SLS). This provides a 5.3% sample of the population of Scotland from the 1991 Census. The research applies the Cox proportional hazard model to estimate the speed to first birth during a period of observation between 1991 and 2006. Class is measured using NS-SEC 8 class analytic version. The model controls marital status, educational attainment, raised religion and urban-rural geography. It is found that ‘career men’ who occupy more advantaged occupational positions do not delay first birth in contrast to men in other occupational categories. This is in contrast to the well-known phenomenon of career women who have later childbearing. Our analysis shows that gender inequalities in how the social structure influences childbearing offer an avenue of explanation for wider patterns of social inequality.

Gender, Occupation and First Birth:: Do 'Career Men' Delay First Birth Too? A cohort analysis of first birth in Scotland in times of low fertility

In the period following the turn of the Century European total fertility rates (TFR) dropped to well below replacement. Work examining this highlights that cohort postponement in births contributes to low TFRs. It is generally recognised that women in more advantaged occupations often postpone childbearing in contrast to those in less advantaged occupational groups. However, relatively little research has been conducted on men in similar terms. This paper contrasts the timing of first birth by occupational class between men and women using individual level data in a case study of Scotland. The data are an extract from the Scottish Longitudinal Study (SLS). This provides a 5.3% sample of the population of Scotland from the 1991 Census. The research applies the Cox proportional hazard model to estimate the speed to first birth during a period of observation between 1991 and 2006. Class is measured using NS-SEC 8 class analytic version. The model controls marital status, educational attainment, raised religion and urban-rural geography. It is found that ‘career men’ who occupy more advantaged occupational positions do not delay first birth in contrast to men in other occupational categories. This is in contrast to the well-known phenomenon of career women who have later childbearing. Our analysis shows that gender inequalities in how the social structure influences childbearing offer an avenue of explanation for wider patterns of social inequality.

Gender, Occupation and First Birth:

In the period following the turn of the Century European total fertility rates (TFR) dropped to well below replacement. Work examining this highlights that cohort postponement in births contributes to low TFRs. It is generally recognised that women in more advantaged occupations often postpone childbearing in contrast to those in less advantaged occupational groups. However, relatively little research has been conducted on men in similar terms. This paper contrasts the timing of first birth by occupational class between men and women using individual level data in a case study of Scotland. The data are an extract from the Scottish Longitudinal Study (SLS). This provides a 5.3% sample of the population of Scotland from the 1991 Census. The research applies the Cox proportional hazard model to estimate the speed to first birth during a period of observation between 1991 and 2006. Class is measured using NS-SEC 8 class analytic version. The model controls marital status, educational attainment, raised religion and urban-rural geography. It is found that ‘career men’ who occupy more advantaged occupational positions do not delay first birth in contrast to men in other occupational categories. This is in contrast to the well-known phenomenon of career women who have later childbearing. Our analysis shows that gender inequalities in how the social structure influences childbearing offer an avenue of explanation for wider patterns of social inequality.

A practical guide to using panel data

Using panel data introduces the reader to the analysis of panel data. It is based upon post graduate courses taught at the Institute of Social and Economic Research (University of Essex). In this r...