Khurshid Iqbal

Lipid peroxidation during acute coronary syndromes and its intensification at the time of myocardial ischemia reperfusion

We conclude that there is an excess of lipid peroxidation in patients with coronary artery disease, and the peroxidative processes are further intensified at the time of AMI and UAP. During the course of AMI, a peroxidative burst is observed in the first few hours after thrombolytic therapy.

Unusual dysmorphic features in five patients with Noonan's syndrome: A brief review

Abstract:  Noonans syndrome is a relatively common, multiple congenital anomaly syndrome, genetically inherited as an autosomal dominant disorder with variable penetrance. It is defined by a characteristic phenotype, congenital heart disease, ocular defects and mild mental retardation. Molecular studies have confirmed that it is a heterogeneous disorder and there may be evidence for an autosomal recessive mode of inheritance. 1 The gene responsible for Noonan’ syndrome has been mapped to the long arm of chromosome 12. 2,3 The human deltex gene (DLT × 1), mapping to chromosomal region 12q24 in the vicinity of the Noonans syndrome critical region is being evaluated as a candidate gene for this disorder. 4 Various types of musculoskeletal abnormalities have been reported, including short stature, craniofacial dysmorphism, short or webbed neck and fetal pads in fingers and toes. 5 We report five cases with the unusual physical features of overriding toes and simian creases. Such abnormalities can be considered among the minor manifestations of the syndrome.

Measurement of plasma lipids in patients admitted with acute myocardial infarction or unstable angina pectoris

We assessed the reliability of early (first day) plasma lipid measurements in patients admitted with acute myocardial infarction or unstable angina pectoris. In 55 such patients, plasma levels of cholesterol and triglycerides measured within the first 24 hours after admission were significantly lower than the corresponding values at 6 weeks, which means that even very early in-hospital lipid measurements could lead to potentially serious underestimation of the lipid risk in these patients ad defined by the current criteria.

ROLE OF THIAMINE DEFICIENCY AND EFFICACY OF THIAMINE IN TREATMENT OF PATIENTS WITH HEART FAILURE.

* Dr. Shamim Iqbal 1 , Dr. Tariq Abdullah 2 , Dr. Nuzhat 3 , Dr. Khurshid Iqbal 4 and Dr. Mir Ishaq 5 . 1. Consultant Cardiologist, MMABM Hospital, Anantnag. 2. Consultant Physician, MMABM Hospital, Anantnag. 3. Medical Officer, Health & Medical Education, J&K. 4. Ex-Professor and Head, Department of Cardiology, SKIMS. 5. General Practitioner. ...................................................................................................................... Manuscript Info Abstract ......................... ........................................................................ Manuscript History

Clinical profile in arrhythmogenic cardiomyopathy and a recessive plakophilin-2 gene mutation

Objective Arrhythmogenic cardiomyopathy (ACM) is not an uncommon cause of cardiac morbidity in Kashmir valley. This study was designed to document various clinical features and to sequence exons 11 and 12 of plakophilin 2 (PKP2) gene in these patients. Methods ACM patients who attended cardiology outpatient department of our institute from January 2014 to April 2015 were included in the study. Their records were reviewed. Controls were randomly selected, who had no history or family history of cardiac illness and had a normal cardiac examination. A blood sample was also taken from both the groups for sequencing of exon 11 and 12 of PKP2 gene. ACM patients were followed up until July 2016. Results Eleven ACM patients and seven controls were included in the study. Most common mode of presentation was ventricular tachycardia (VT). Two patients had left ventricular (LV) systolic dysfunction. One patient had a splice site mutation in exon 12 of PKP2 gene and one patient died during follow-up. One of the controls had an intronic variation that has no pathogenic significance vis-à-vis ACM. Conclusion Our study describes various clinical parameters in ACM patients and a recessive plakophilin 2 mutation after a limited PKP2 gene sequencing.

Lymphoma Presenting as Severe Left Ventricular Systolic Dysfunction: A Case Report

Lymphoma involving the heart is rare. This is a case report on non-Hodgkin lymphoma where the patient presented for the first time with heart failure and severe left ventricular systolic dysfunction due to lymphoma infiltrating the heart muscle and had simultaneous bilateral involvement of kidneys. This type of presentation has never been described in world literature and is the first reported case.

Combined severe valvular aortic and valvular pulmonary stenosis and its management - A case report and literature review.

Isolated congenital valvular stenosis of either aortic or pulmonary valve is commonly seen yet the presence of both these lesions in the same patient is rare. This combination presents unusual diagnostic as well as management problems. Apart from a few case reports, there is little in the literature on the combined stenosis of both semilunar valves. We present here a case report of a three and half year old boy diagnosed as a combined congenital severe valvular aortic stenosis with valvular pulmonary stenosis. The patient underwent successful balloon dilatation of both these valves in the same sitting.