Ki Baik Hahm

5-LOX inhibitor modulates the inflammatory responses provoked by Helicobacter pylori infection

Background:u2002 Arachidonic acid metabolites have been considered as pivotal mediators in Helicobacter pylori‐induced inflammatory response, which are mainly metabolized by two distinct enzymes: cyclooxygenase (COX) and lipoxygenase (LOX). While COX has become well known to play a key role in either carcinogenesis or inflammation related to H. pylori infection, little is known regarding the implication of LOX in H. pylori infection. In this study, we evaluated the roles of 5‐LOX and its metabolites in H. pylori‐induced host responses and further a potential beneficial action of specific LOX inhibitors against H. pylori infection.