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Dive into the research topics where Kim C. Quon is active.

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Featured researches published by Kim C. Quon.


Cell | 1996

Cell Cycle Control by an Essential Bacterial Two-Component Signal Transduction Protein

Kim C. Quon; Gregory T. Marczynski; Lucy Shapiro

Dividing cells must coordinate cell cycle events to ensure genetic stability. Here we identify an essential two-component signal transduction protein that controls multiple events in the Caulobacter cell cycle, including cell division, stalk synthesis, and cell cycle-specific transcription. This protein, CtrA, is homologous to response regulator transcription factors and controls transcription from a group of cell cycle-regulated promoters critical for DNA replication, DNA methylation, and flagellar biogenesis. CtrA activity in the cell cycle is controlled both transcriptionally and by phosphorylation. As purified CtrA binds an essential DNA sequence motif found within its target promoters, we propose that CtrA acts in a phosphorelay signal transduction system to control bacterial cell cycle events directly at the transcriptional level.


Cell | 1997

Cell type-specific phosphorylation and proteolysis of a transcriptional regulator controls the G1-to-S transition in a bacterial cell cycle.

Ibrahim J. Domian; Kim C. Quon; Lucy Shapiro

The global transcriptional regulator CtrA controls multiple events in the Caulobacter cell cycle, including the initiation of DNA replication, DNA methylation, cell division, and flagellar biogenesis. CtrA is a member of the response regulator family of two component signal transduction systems and is activated by phosphorylation. We report here that this phosphorylation signal enters the cell cycle at mid S phase. In addition, CtrA function is modulated by temporally and spatially controlled proteolysis. When an active CtrA protein is present at the wrong time in the cell cycle, owing to expression of a mutant CtrA derivative that is active in the absence of phosphorylation and is not turned over during the cell cycle, the G1-to-S transition is blocked and the cell cycle aborts. Thus, both phosphorylation and proteolysis are critical determinants of bacterial cell cycle control in a manner that is analogous to the control of the eukaryotic cell cycle.


Current Opinion in Genetics & Development | 1996

The control of temporal and spatial organization during the Caulobacter cell cycle

Ibrahim J. Domian; Kim C. Quon; Lucy Shapiro

The Caulobacter cell cycle exhibits time-dependent expression of differentiation events. These include the morphological transition of a swarmer cell to a replication-competent stalked cell and the subsequent polarized distribution of specific gene products that results in an asymmetric predivisional cell. Cell division then yields a new swarmer cell and a stem-cell-like stalked cell. Two-component signal transduction proteins involved in cell cycle control and proteins required for cell division and flagellar biogenesis have been shown to be regulated temporally and spatially during the cell cycle. The mechanisms underlying this regulation include protein phosphorylation and proteolysis.


Proceedings of the National Academy of Sciences of the United States of America | 1998

Negative control of bacterial DNA replication by a cell cycle regulatory protein that binds at the chromosome origin

Kim C. Quon; Bing Yang; Ibrahim J. Domian; Lucy Shapiro; Gregory T. Marczynski


Proceedings of the National Academy of Sciences of the United States of America | 2004

Identification of p53 regulators by genome-wide functional analysis

Qihong Huang; Angel Raya; Paul DeJesus; Sheng-Hao Chao; Kim C. Quon; Jeremy S. Caldwell; Sumit K. Chanda; Juan Carlos Izpisúa-Belmonte; Peter G. Schultz


Journal of Bacteriology | 1999

The CtrA Response Regulator Mediates Temporal Control of Gene Expression during the Caulobacter Cell Cycle

Ann Reisenauer; Kim C. Quon; Lucy Shapiro


Proceedings of the National Academy of Sciences of the United States of America | 2005

A TRAIL receptor-dependent synthetic lethal relationship between Myc activation and GSK3β/FBW7 loss of function

Sabine Rottmann; Yan Wang; Marc Nasoff; Quinn Deveraux; Kim C. Quon


Journal of Bacteriology | 1992

Expression of an early gene in the flagellar regulatory hierarchy is sensitive to an interruption in DNA replication.

A Dingwall; Wei Yun Zhuang; Kim C. Quon; Lucy Shapiro


Archive | 2006

ENHANCING MYC-DEPENDENT SENSITIVITY OF CANCER TO DR5 AGONISTS

Quinn Deveraux; Marc Nasoff; Kim C. Quon; Sabine Rottman


Archive | 2006

Amplification de la sensibilité dépendante de myc d'un cancer à des agonistes de dr5

Quinn Deveraux; Marc Nasoff; Kim C. Quon; Sabine Rottman

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Marc Nasoff

Genomics Institute of the Novartis Research Foundation

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Jeremy S. Caldwell

Genomics Institute of the Novartis Research Foundation

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Juan Carlos Izpisúa-Belmonte

Salk Institute for Biological Studies

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Paul DeJesus

Genomics Institute of the Novartis Research Foundation

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