Kim Malesky
Genentech
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Publication
Featured researches published by Kim Malesky.
ACS Medicinal Chemistry Letters | 2011
Steve Wenglowsky; Li Ren; Ellen R. Laird; Ignacio Aliagas; Bruno Alicke; Alex J. Buckmelter; Edna F. Choo; Victoria Dinkel; Bainian Feng; Susan L. Gloor; Stephen E. Gould; Stefan Gross; Janet Gunzner-Toste; Joshua D. Hansen; Georgia Hatzivassiliou; Bonnie Liu; Kim Malesky; Simon Mathieu; Brad Newhouse; Nicholas Raddatz; Yingqing Ran; Sumeet Rana; Nikole Randolph; Tyler Risom; Joachim Rudolph; Scott Savage; LeAnn T. Selby; Michael Shrag; Kyung Song; Hillary L. Sturgis
The V600E mutation of B-Raf kinase results in constitutive activation of the MAPK signaling pathway and is present in approximately 7% of all cancers. Using structure-based design, a novel series of pyrazolopyridine inhibitors of B-Raf(V600E) was developed. Optimization led to the identification of 3-methoxy pyrazolopyridines 17 and 19, potent, selective, and orally bioavailable agents that inhibited tumor growth in a mouse xenograft model driven by B-Raf(V600E) with no effect on body weight. On the basis of their in vivo efficacy and preliminary safety profiles, 17 and 19 were selected for further preclinical evaluation.
Archive | 2010
Kateri A. Ahrendt; Alexandre J. Buckmelter; Jonas Grina; Joshua D. Hansen; Ellen R. Laird; David Moreno; Brad Newhouse; Li Ren; Steven Mark Wenglowsky; Bainian Feng; Janet Gunzner; Kim Malesky; Simon Mathieu; Joachim Rudolph; Zhaoyang Wen; Wendy B. Young
Archive | 2009
Kateri A. Ahrendt; Alexandre J. Buckmelter; Jonas Grina; Joshua D. Hansen; Ellen R. Laird; Brad Newhouse; Li Ren; Steven Mark Wenglowsky; Bainian Feng; Kim Malesky; Simon Mathieu; Joachim Rudolph; Zhaoyang Wen; Wendy B. Young; David Moreno
Archive | 2009
Kateri A. Ahrendt; Alexandre J. Buckmelter; Jason De Meese; Jonas Grina; Joshua D. Hansen; Ellen R. Laird; Paul Lunghofer; David Moreno; Brad Newhouse; Li Ren; Jeongbeob Seo; Hongqi Tian; Steven Mark Wenglowsky; Bainian Feng; Janet Gunzner; Kim Malesky; Simon Mathieu; Joachim Rudolph; Zhaoyang Wen; Wendy B. Young
Archive | 2009
Kateri A. Ahrendt; Alexandre J. Buckmelter; Jonas Grina; Joshua D. Hansen; Ellen R. Laird; David Moreno; Brad Newhouse; Li Ren; Steven Mark Wenglowsky; Bainian Feng; Janet Gunzner; Kim Malesky; Simon Mathieu; Joachim Rudolph; Zhaoyang Wen; Wendy B. Young
Archive | 2009
Kateri A. Ahrendt; Alexandre J. Buckmelter; Jonas Grina; Joshua D. Hansen; Ellen R. Laird; Brad Newhouse; Li Ren; Steven Mark Wenglowsky; Bainian Feng; Kim Malesky; Simon Mathieu; Joachim Rudolph; Zhaoyang Wen; Wendy B. Young; David Moreno
Archive | 2009
Kateri A. Ahrendt; Alexandre J. Buckmelter; Jonas Grina; Joshua D. Hansen; Ellen R. Laird; Brad Newhouse; Li Ren; Steven Mark Wenglowsky; Bainian Feng; Kim Malesky; Simon Mathieu; Joachim Rudolph; Zhaoyang Wen; Wendy B. Young; David Moreno
Archive | 2009
Kateri A. Ahrendt; Alexandre J. Buckmelter; Bainian Feng; Jonas Grina; Joshua D. Hansen; Ellen R. Laird; Kim Malesky; Simon Mathieu; David Moreno; Brad Newhouse; Li Ren; Joachim Rudolph; Zhaoyang Wen; Steven Mark Wenglowsky; Wendy B. Young
Archive | 2009
Kateri A. Ahrendt; Alexandre J. Buckmelter; Meese Jason De; Jonas Grina; Joshua D. Hansen; Ellen R. Laird; Paul Lunghofer; David Moreno; Brad Newhouse; Li Ren; Jeongbeob Seo; Hongqi Tian; Steven Mark Wenglowsky; Bainian Feng; Janet Gunzner; Kim Malesky; Simon Mathieu; Joachim Rudolph; Zhaoyang Wen; Wendy B. Young
Archive | 2009
Kateri A. Ahrendt; Alexandre J. Buckmelter; Meese Jason De; Jonas Grina; Joshua D. Hansen; Ellen R. Laird; Paul Lunghofer; David Moreno; Brad Newhouse; Li Ren; Jeongbeob Seo; Hongqi Tian; Steven Mark Wenglowsky; Bainian Feng; Janet Gunzner; Kim Malesky; Simon Mathieu; Joachim Rudolph; Zhaoyang Wen; Wendy B. Young
