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Dive into the research topics where Kimberlie A. Graeme is active.

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Featured researches published by Kimberlie A. Graeme.


Journal of Emergency Medicine | 2002

Respiratory compromise in patients with rattlesnake envenomation

Daniel E. Brooks; Kimberlie A. Graeme; Anne-Michelle Ruha; David A. Tanen

Respiratory compromise after rattlesnake envenomation (RSE) is an uncommon yet potentially lethal complication. We were interested in determining the frequency of respiratory compromise in patients treated for RSE. The incidence and indications for intubation were also determined. A retrospective chart review was conducted of all patients treated by medical toxicologists at a tertiary referral hospital between July, 1994 and November, 2000. Out of 294 total patients, 289 charts were reviewed. Of all 289 patients, 214 (74%) received Crotalidae Polyvalent Antivenin (Wyeth-Ayerst) and 23 (8%) had clinical evidence of respiratory compromise. Thirteen of 289 patients (4.4%) were intubated following RSE. No one was intubated for antivenin-induced complications. There were no deaths among studied patients during acute hospitalization. Respiratory compromise following RSE is rare, occurring in only 8% of studied patients. Only 2 patients (0.7%) required intubation as a direct consequence of RSE. No one required intubation for antivenin-induced hypersensitivity reactions.


Journal of Medical Toxicology | 2014

Mycetism: a review of the recent literature.

Kimberlie A. Graeme

Approximately 100 of the known species of mushrooms are poisonous to humans. New toxic mushroom species continue to be identified. Some species initially classified as edible are later reclassified as toxic. This results in a continually expanding list of toxic mushrooms. As new toxic species are identified, some classic teachings about mycetism no longer hold true. As more toxic mushrooms are identified and more toxic syndromes are reported, older classification systems fail to effectively accommodate mycetism. This review provides an update of myscetism and classifies mushroom poisonings by the primary organ system affected, permitting expansion, as new, toxic mushroom species are discovered.


Clinical Toxicology | 2000

Crack Cocaine Ingestion with Prolonged Toxicity Requiring Electrical Pacing

David A. Tanen; Kimberlie A. Graeme; Steven C. Curry

Case Report: We report a 38-year-old man who experienced prolonged toxicity lasting over 16 hours from the time of ingestion of ¼ ounce of crack cocaine. His illness included status epilepticus, wide and narrow complex bradyarrhythmias, ventricular arrhythmias, and delayed hyperthermia. His bradyarrhythmias were refractory to medicinal intervention and responsive to application of an external pacemaker. The patient recovered to his baseline state over the ensuing 48 hours.


Anesthesia & Analgesia | 1999

The lack of transplacental movement of the cyanide antidote thiosulfate in gravid ewes

Kimberlie A. Graeme; Steven C. Curry; Dale S. Bikin; Frank LoVecchio; Tedd A. Brandon

UNLABELLED A previous study reported that the co-infusion of IV sodium thiosulfate (STS) with sodium nitroprusside (SNP) to near-term gravid ewes prevented both maternal and fetal cyanide toxicity. We questioned whether maternally administered STS crossed the ovine placenta to enhance fetal transulfuration of cyanide, or whether the fetus was dependent on maternal detoxification of cyanide after diffusion of cyanide into the maternal circulation. Ten anesthetized, near-term gravid ewes underwent hysterotomies with delivery of fetal heads for venous catheterization. Five control ewes received IV isotonic sodium chloride solution, whereas five experimental ewes received IV STS (50 mg/kg over 15 min). Serial plasma thiosulfate concentrations in ewes and fetuses were measured over 135 min. Areas under the time-plasma thiosulfate concentration curves were calculated for experimental and control ewes at 2758+/-197 and 508+/-74 min x mg(-1) x L(-1), respectively (P < 0.008). Mean areas under the curve for experimental and control fetuses were 236+/-34 and 265+/-23 min x mg(-1) x L(-1), respectively (P > 0.5). Maternally administered STS may prevent fetal cyanide poisoning from SNP administration without relying on STS crossing the placenta into the fetal circulation. Fetal cyanide may cross down a concentration gradient from fetal to maternal circulation, to be transulfurated to thiocyanate in maternal tissues. IMPLICATIONS We evaluated the mechanism of action of sodium thiosulfide (STS) in sodium nitroprusside-induced cyanide toxicity in the ewe. Fetal cyanide poisoning is alleviated by maternal administration of STS, although this cyanide antidote apparently does not cross the placenta.


Science | 1988

Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells

Barry S. Komm; Christopher M. Terpening; David J. Benz; Kimberlie A. Graeme; Alfred Gallegos; Murray Korc; Geoffrey L. Greene; Bert W. O'Malley; Mark R. Haussler


Annals of Emergency Medicine | 2002

Initial postmarketing experience with crotalidae polyvalent immune Fab for treatment of rattlesnake envenomation

Anne Michelle Ruha; Steven C. Curry; Michael C. Beuhler; Ken Katz; Daniel E. Brooks; Kimberlie A. Graeme; Kevin L. Wallace; Richard Gerkin; Frank LoVecchio; Paul M. Wax; Brad S Selden


Academic Emergency Medicine | 2001

Epidemiology and Hospital Course of Rattlesnake Envenomations Cared for at a Tertiary Referral Center in Central Arizona

David A. Tanen; Anne-Michelle Ruha; Kimberlie A. Graeme; Steven C. Curry


The New England Journal of Medicine | 1999

Severe lung injury after exposure to chloramine gas from household cleaners.

David A. Tanen; Kimberlie A. Graeme; Robert Raschke


Annals of Emergency Medicine | 2000

Hypertonic Sodium Bicarbonate Is Effective in the Acute Management of Verapamil Toxicity in a Swine Model

David A. Tanen; Anne-Michelle Ruha; Steven C. Curry; Kimberlie A. Graeme; Christine G. Reagan


Academic Emergency Medicine | 2002

Hypertonic Sodium Bicarbonate for Taxus media‐induced Cardiac Toxicity in Swine

Kimberlie A. Graeme; Anne-Michelle Ruha; David A. Tanen; Steven C. Curry; Mary Beth Miller; Richard Gerkin; Christine G. Reagan; Tedd A. Brandon

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David A. Tanen

Naval Medical Center San Diego

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Frank LoVecchio

Good Samaritan Medical Center

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Anne Michelle Ruha

Good Samaritan Medical Center

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Daniel E. Brooks

Good Samaritan Medical Center

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Denise L. Kurta

Boston Children's Hospital

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