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Dive into the research topics where Kimberly J. Schlesinger is active.

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Featured researches published by Kimberly J. Schlesinger.


PLOS Computational Biology | 2015

Brain Network Adaptability across Task States

Elizabeth N. Davison; Kimberly J. Schlesinger; Danielle S. Bassett; Mary-Ellen Lynall; Michael B. Miller; Scott T. Grafton; Jean M. Carlson

Activity in the human brain moves between diverse functional states to meet the demands of our dynamic environment, but fundamental principles guiding these transitions remain poorly understood. Here, we capitalize on recent advances in network science to analyze patterns of functional interactions between brain regions. We use dynamic network representations to probe the landscape of brain reconfigurations that accompany task performance both within and between four cognitive states: a task-free resting state, an attention-demanding state, and two memory-demanding states. Using the formalism of hypergraphs, we identify the presence of groups of functional interactions that fluctuate coherently in strength over time both within (task-specific) and across (task-general) brain states. In contrast to prior emphases on the complexity of many dyadic (region-to-region) relationships, these results demonstrate that brain adaptability can be described by common processes that drive the dynamic integration of cognitive systems. Moreover, our results establish the hypergraph as an effective measure for understanding functional brain dynamics, which may also prove useful in examining cross-task, cross-age, and cross-cohort functional change.


PLOS Computational Biology | 2016

Individual Differences in Dynamic Functional Brain Connectivity across the Human Lifespan

Elizabeth N. Davison; Benjamin O. Turner; Kimberly J. Schlesinger; Michael B. Miller; Scott T. Grafton; Danielle S. Bassett; Jean M. Carlson

Individual differences in brain functional networks may be related to complex personal identifiers, including health, age, and ability. Dynamic network theory has been used to identify properties of dynamic brain function from fMRI data, but the majority of analyses and findings remain at the level of the group. Here, we apply hypergraph analysis, a method from dynamic network theory, to quantify individual differences in brain functional dynamics. Using a summary metric derived from the hypergraph formalism—hypergraph cardinality—we investigate individual variations in two separate, complementary data sets. The first data set (“multi-task”) consists of 77 individuals engaging in four consecutive cognitive tasks. We observe that hypergraph cardinality exhibits variation across individuals while remaining consistent within individuals between tasks; moreover, the analysis of one of the memory tasks revealed a marginally significant correspondence between hypergraph cardinality and age. This finding motivated a similar analysis of the second data set (“age-memory”), in which 95 individuals, aged 18–75, performed a memory task with a similar structure to the multi-task memory task. With the increased age range in the age-memory data set, the correlation between hypergraph cardinality and age correspondence becomes significant. We discuss these results in the context of the well-known finding linking age with network structure, and suggest that hypergraph analysis should serve as a useful tool in furthering our understanding of the dynamic network structure of the brain.


NeuroImage | 2017

Age-dependent changes in task-based modular organization of the human brain

Kimberly J. Schlesinger; Benjamin O. Turner; Brian Lopez; Michael B. Miller; Jean M. Carlson

Abstract As humans age, cognition and behavior change significantly, along with associated brain function and organization. Aging has been shown to decrease variability in functional magnetic resonance imaging (fMRI) signals, and to affect the modular organization of human brain function. In this work, we use complex network analysis to investigate the dynamic community structure of large‐scale brain function, asking how evolving communities interact with known brain systems, and how the dynamics of communities and brain systems are affected by age. We analyze dynamic networks derived from fMRI scans of 104 human subjects performing a word memory task, and determine the time‐evolving modular structure of these networks by maximizing the multislice modularity, thereby identifying distinct communities, or sets of brain regions with strong intra‐set functional coherence. To understand how community structure changes over time, we examine the number of communities as well as the flexibility, or the likelihood that brain regions will switch between communities. We find a significant positive correlation between age and both these measures: younger subjects tend to have less fragmented and more coherent communities, and their brain regions tend to change communities less often during the memory task. We characterize the relationship of community structure to known brain systems by the recruitment coefficient, or the probability of a brain region being grouped in the same community as other regions in the same system. We find that regions associated with cingulo‐opercular, somatosensory, ventral attention, and subcortical circuits have a significantly higher recruitment coefficient in younger subjects. This indicates that the within‐system functional coherence of these specific systems during the memory task declines with age. Such a correspondence does not exist for other systems (e.g. visual and default mode), whose recruitment coefficients remain relatively uniform across ages. These results confirm that the dynamics of functional community structure vary with age, and demonstrate methods for investigating how aging differentially impacts the functional organization of different brain systems. HighlightsDynamics of task‐active brain communities are quantified in adults of varying ages.Community number and node flexibility are positively associated with subject age.Dynamics of intrinsic functional networks are differentially modulated by age.No correspondence is found between age or brain dynamics and task performance.


PLOS ONE | 2014

Coevolutionary immune system dynamics driving pathogen speciation.

Kimberly J. Schlesinger; Sean P. Stromberg; Jean M. Carlson

We introduce and analyze a within-host dynamical model of the coevolution between rapidly mutating pathogens and the adaptive immune response. Pathogen mutation and a homeostatic constraint on lymphocytes both play a role in allowing the development of chronic infection, rather than quick pathogen clearance. The dynamics of these chronic infections display emergent structure, including branching patterns corresponding to asexual pathogen speciation, which is fundamentally driven by the coevolutionary interaction. Over time, continued branching creates an increasingly fragile immune system, and leads to the eventual catastrophic loss of immune control.


advances in social networks analysis and mining | 2017

Data-Driven Models for Individual and Group Decision Making

Chantal Nguyen; Kimberly J. Schlesinger; Jean M. Carlson

Quantifying the dynamics of collective human decision making is essential to optimizing communication systems, transportation networks, and action protocols for ensuring public safety in uncertain and risky situations. Representing human factors has been elusive since decision making is driven by a host of interacting factors such as time pressure, perceived risks, and social influence. We develop two complementary datadriven models to describe decision making in natural disaster scenarios based upon the observed behavior of subjects in a controlled behavioral experiment where participants must decide whether and when to evacuate from a virtual natural disaster. We first develop a rate-based model that quantifies an individual’s decision-making strategy as a function of the reported disaster threat level, which we observe to be a primary influence of collective behavior, and use this model to simulate and predict evacuation at the population level. We investigate the effect of social influence on strategy adjustments that emerge in group contexts, comparing evacuation decisions made individually with those that are arrived at via group consensus or vote. We find that the accurate characterization of group behavior mandates the consideration of individual heterogeneity, leading to a second approach using an artificial neural network which incorporates more experimental parameters, including a measure of individual variation, to predict precise evacuation times. An alternative method of quantifying individual differences in the neural network uses participants’ social media data as input to the model and achieves comparable prediction accuracy.


PLOS ONE | 2017

Improving resolution of dynamic communities in human brain networks through targeted node removal

Kimberly J. Schlesinger; Benjamin O. Turner; Scott T. Grafton; Michael B. Miller; Jean M. Carlson; Daniele Marinazzo

Current approaches to dynamic community detection in complex networks can fail to identify multi-scale community structure, or to resolve key features of community dynamics. We propose a targeted node removal technique to improve the resolution of community detection. Using synthetic oscillator networks with well-defined “ground truth” communities, we quantify the community detection performance of a common modularity maximization algorithm. We show that the performance of the algorithm on communities of a given size deteriorates when these communities are embedded in multi-scale networks with communities of different sizes, compared to the performance in a single-scale network. We demonstrate that targeted node removal during community detection improves performance on multi-scale networks, particularly when removing the most functionally cohesive nodes. Applying this approach to network neuroscience, we compare dynamic functional brain networks derived from fMRI data taken during both repetitive single-task and varied multi-task experiments. After the removal of regions in visual cortex, the most coherent functional brain area during the tasks, community detection is better able to resolve known functional brain systems into communities. In addition, node removal enables the algorithm to distinguish clear differences in brain network dynamics between these experiments, revealing task-switching behavior that was not identified with the visual regions present in the network. These results indicate that targeted node removal can improve spatial and temporal resolution in community detection, and they demonstrate a promising approach for comparison of network dynamics between neuroscientific data sets with different resolution parameters.


arXiv: Physics and Society | 2016

Collective Decision Dynamics in Group Evacuation: Behavioral Experiment and Machine Learning Models

Chantal Nguyen; Fangqiu Han; Kimberly J. Schlesinger; Izzeddin Gür; Jean M. Carlson


Fire Technology | 2018

Modeling Individual and Group Evacuation Decisions During Wildfires

Chantal Nguyen; Kimberly J. Schlesinger; Fangqiu Han; Izzeddin Gür; Jean M. Carlson


arXiv: Physics and Society | 2016

Collective Decision Dynamics in Group Evacuation II: Modeling Tradeoffs and Optimal Behavior

Kimberly J. Schlesinger; Chantal Nguyen; Imtiaz Ali; Jean M. Carlson


arXiv: Physics and Society | 2016

Decision Dynamics in Group Evacuation.

Fangqiu Han; Chantal Nguyen; Kimberly J. Schlesinger; Izzeddin Gür; Jean M. Carlson

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Chantal Nguyen

University of California

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Brian Lopez

University of California

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