Kimihiko Yukisada
University of Tsukuba
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Featured researches published by Kimihiko Yukisada.
Journal of the American College of Cardiology | 1990
Yasuro Sugishita; Keiji Iida; Kimihiko Yukisada; Iwao Ito
To study the cardiac determinants of regression of left ventricular hypertrophy in hypertension, left ventricular mass, fractional shortening and end-systolic wall stress were measured echocardiographically in 36 patients with essential hypertension and left ventricular hypertrophy. The patients were classified into two groups. Group I consisted of 15 patients with subnormal end-systolic wall stress, and Group II consisted of 21 patients with normal end-systolic wall stress. There were no significant differences between groups in systolic or diastolic blood pressure. After treatment for 4.4 +/- 1.7 years, echocardiographic studies were repeated. There were no significant differences between groups in the duration of the follow-up period and the kinds of antihypertensive drugs. After treatment, blood pressure decreased significantly in both groups (p less than 0.001 for both), with no significant difference between groups. Left ventricular mass increased significantly in Group I (from 331 +/- 7 to 363 +/- 24 g, mean +/- SEM, p less than 0.05), whereas it decreased significantly in Group II (from 318 +/- 16 to 268 +/- 17 g, p less than 0.001). Myocardial contractility (the relation between end-systolic wall stress and fractional shortening) remained almost the same as before treatment. In conclusion, in patients with hypertensive ventricular hypertrophy with subnormal end-systolic wall stress (inappropriate hypertrophy, probably induced by a neurohumoral factor), a decrease in blood pressure with antihypertensive treatment does not lead to regression of left ventricular hypertrophy, but rather to an increase in left ventricular mass.(ABSTRACT TRUNCATED AT 250 WORDS)
Journal of the American College of Cardiology | 1995
Satoru Kawano; Keiji Iida; Katsuji Fujieda; Kimihiko Yukisada; El Sersi Magdi; Yuko Iwasaki; Fumiko Tabei; Iwao Yamaguchi; Yasuro Sugishita
OBJECTIVES We sought to assess whether isoproterenol stress echocardiography could detect in advance in which patients hypertrophic cardiomyopathy would progress to a phase resembling dilated cardiomyopathy. BACKGROUND In a few patients, hypertrophic cardiomyopathy has been reported to progress to a phase characterized by systolic dysfunction and left ventricular dilation, resembling dilated cardiomyopathy. METHODS Echocardiograms were recorded before and immediately after intravenous infusion of isoproterenol (0.02 microgram/kg body weight per min) for 5 min in 18 patients with typical hypertrophic cardiomyopathy (i.e., hypertrophied, hyperdynamic and nondilated) to determine the difference in fractional shortening. The patients were categorized into those with a good response (difference in fractional shortening > 7%, 14 patients) and those with a poor response (difference < or = 7%, 4 patients). Changes in left ventricular end-diastolic diameter and fractional shortening were evaluated by using serial echocardiography over an average follow-up period of 5.4 years. RESULTS In the good response group, neither end-diastolic diameter nor fractional shortening changed significantly during the follow-up period. In the poor response group, end-diastolic diameter significantly increased from a mean +/- SD of 41 +/- 5 to 53 +/- 5 mm (p < 0.05), and fractional shortening significantly decreased from 40 +/- 12% to 29 +/- 10% (p < 0.05). All patients in the poor response group showed a substantial decrease (> or = 5%) in fractional shortening and an increase (> or = 5 mm) in end-diastolic diameter. One patient developed congestive heart failure due to systolic dysfunction during the observation period. CONCLUSIONS The present study confirmed that impaired responses to isoproterenol infusion are related to future deterioration of left ventricular performance in patients with typical hypertrophic cardiomyopathy.
Clinical Cardiology | 1986
Kaname Iida; Yasuro Sugishita; Mitsuo Matsuda; T. Yamaguchi; Ryuichi Ajisaka; Ryuma Matsumoto; Takanori Fujita; Kimihiko Yukisada; Iwao Ito
Japanese Journal of Medicine | 1990
Keiji Iida; Yoshinobu Koide; Yasuro Sugishita; Mitsuo Matsuda; Kouichi Kawai; Kimihiko Yukisada; Yuji Tomono; Kamejiro Yamashita; Iwao Ito
Clinical Cardiology | 1994
Yasuro Sugishita; Keiji Iida; Kazushi Fujieda; Kimihiko Yukisada
Japanese Circulation Journal-english Edition | 1990
Yasuro Sugishita; Keiji Iida; Kimihiko Yukisada
Clinical Cardiology | 1990
Kaname Iida; Yasuro Sugishita; Kimihiko Yukisada; Iwao Ito
Clinical Cardiology | 1987
Kaname Iida; Kimihiko Yukisada; Yasuro Sugishita; Mitsuo Matsuda; Susumu Koseki; Iwao Ito
Japanese Heart Journal | 1986
Takanori Fujita; Ryuichi Ajisaka; Kimihiko Yukisada; Yasuro Sugishita; Iwao Ito
Japanese Heart Journal | 1995
Katsuji Fujieda; Keiji Iida; Satoru Kawao; Kimihiko Yukisada; Iwao Yamaguchi; Yasuro Sugishita