Kimihiro Nakae
Dokkyo University
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Featured researches published by Kimihiro Nakae.
The Lancet | 1989
Kanjiro Masuda; Akira Urayama; Mitsuko Kogure; Akira Nakajima; Kimihiro Nakae; Goro Inaba
The efficacy and safety of oral cyclosporin 10 mg/kg per day in Behçets disease were compared in a randomised double-masked study with those of colchicine, 1 mg orally per day, and were also investigated in a long-term open study. The double-masked study showed that cyclosporin was effective in treating not only the ocular manifestations of Behçets disease but also oral aphthous ulcer, dermal lesions, and genital ulceration. Efficacy did not weaken during long-term treatment.
Japanese Journal of Ophthalmology | 2001
Midori Nishiyama; Kimihiro Nakae; Takeshi Umehara
PURPOSE To examine retrospectively the features of Behçets disease patients with familial occurrence and make a comparison between familial Behçets patients with ocular lesions and those without ocular lesions. METHODS We sent questionnaires about Behçets disease patients with familial occurrence to 114 hospitals that reported treating such patients in previous nationwide hospital surveys, and to 341 hospitals selected at random in Japan. RESULTS We obtained reports on 83 Behçets patients with familial occurrence. The positive rate of HLA-B51 was 53.1%. The positive rate of HLA-B51 among patients with ocular lesions was 64.0%, that in patients without ocular lesions was 14.3%, and that in patients with genital ulcers was 40.9%. The mean birth year and onset year of the patients with ocular symptoms was significantly lower than that of the patients without ocular symptoms. Although there was no significant difference between these two groups, parent-child involvement was more common among the patients without ocular lesions than in those with ocular lesions. CONCLUSIONS The findings of this study suggest that the number of familial Behçets disease patients with ocular lesions and high HLA-B51 positivity has been decreasing recently. To elucidate the etiology of familial occurrence, larger scale epidemiological studies and further molecular studies of Behçets disease are needed.
Environmental Health and Preventive Medicine | 1999
Midori Nishiyama; Kimihiro Nakae; Satoru Yukawa; Takashi Hashimoto; Goro Inaba; Manabu Mochizuki; Tsuyoshi Sakane
The 4th nationwide epidemiological survey on Behçet disease (BD), which included all patients with BD at 1,200 hospitals selected at random from 10,081 hospitals in Japan, was carried out by the BD Research Committee of the Ministry of Health and Welfare in 1991 to examine the epidemiological features of BD in Japan by comparing with previous surveys. 3,938 patients from these hospitals were examined by the Japanese diagnostic criteria of BD (JCBD) revised in 1987 and the International criteria for classification of BD (ICBD). Among these 3,938 patients, 622 patients were only suspected of having BD or clinical signs of the disease were unknown, and most of these patients were incompatible with the ICBD. So these patients were excluded from the study of epidemiological features. The average patients age has risen 7–8 years over the last 20 years and the average age of onset in both sexes increased by about 3 years from 1972 to 1991. While a decrease in the sex ratio was seen in the complete-type and the incomplete-type BD without ocular symptoms, a sustained high sex ratio was shown in incomplete-type BD with ocular symptoms. The positive rate of HLA-B51 antigen was 54.9% (men: 56.9%, women: 52.2%) significantly higher than die 15–16% in healthy subjects but it might have been gradually decreasing. Also the clinical course of BD has become too mild for prognosis. According to diese epidemiological features of BD, the clinical manifestation of BD in Japan might have become the Western type of BD.
The Journal of Rheumatology | 2002
Midori Nishiyama; Kimihiro Nakae; Takao Kuriyama; Michiyo Hashimoto; Zin-Ning Hsu
Nippon Jibiinkoka Gakkai Kaiho | 2002
Akihiko Nakamura; Tadao Asai; Kazuhiro Yoshida; Kohtaro Baba; Kimihiro Nakae
Journal of Epidemiology | 2000
Betty Roosihermiatie; Midori Nishiyama; Kimihiro Nakae
Southeast Asian Journal of Tropical Medicine and Public Health | 2000
Betty Roosihermiatie; Midori Nishiyama; Kimihiro Nakae
Southeast Asian Journal of Tropical Medicine and Public Health | 2004
Midori Nishiyama; Masanori Takahashi; Ken-chi Manaka; Betty Roosihermiatie; Takao Kuriyama; Kimihiro Nakae
Southeast Asian Journal of Tropical Medicine and Public Health | 2000
Betty Roosihermiatie; Midori Nishiyama; Kimihiro Nakae
Nippon Eiseigaku Zasshi (japanese Journal of Hygiene) | 1989
Hiroshi Yanagawa; Masaki Nagai; Yasuyuki Fujita; Norihisa Hara; Kimihiro Nakae; Masumi Minowa