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King Chung Lam

Hong Kong University of Science and Technology

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Dalton Transactions | 2004

Theoretical study of reaction pathways for the rhodium phosphine-catalysed borylation of C-H bonds with pinacolborane

Wai Han Lam; King Chung Lam; Zhenyang Lin; Shigeru Shimada; Robin N. Perutz; Todd B. Marder

The reaction mechanism of the rhodium-phosphine catalysed borylation of methyl-substituted arenes using pinacolborane (HBpin) has been investigated theoretically using DFT calculations at the B3PW91 level. Factors affecting selectivity for benzylic vs. aromatic C-H bond activation have been examined. It was found that [Rh(PR3)2(H)] is the active species which oxidatively adds the C-H bond leading to an eta3-benzyl complex which is the key to determining the unusual benzylic regioselectivity observed experimentally for this catalyst system. Subsequent reaction with HBpin leads to a [Rh(PR3)2(eta3-benzyl)(H)(Bpin)] complex from which B-C reductive elimination provides product and regenerates the catalyst. The electrophilic nature of the boryl ligand assists in the reductive elimination process. In contrast to Ir(L)2(boryl)3-based catalysts, for which Ir(III)-Ir(V) cycles have been proposed, the Rh(I)-Rh(III) cycle is operating with the system addressed herein.

Organic and Biomolecular Chemistry | 2006

Regioselectivity in the Sonogashira coupling of 4,6-dichloro-2-pyrone

Ian J. S. Fairlamb; Ciara T. O'Brien; Zhenyang Lin; King Chung Lam

The Sonogashira cross-coupling of 4,6-dichloro-2-pyrone with terminal acetylenes proceeds in good yields and high regioselectivity for the 6-position; dibenzylidene acetone (dba) type ligands play a non-innocent role in reactions mediated by Pd(dba)2/PPh3; theoretical studies indicate that C-6 oxidative addition is favoured both kinetically and thermodynamically.

Organometallics | 2007

DFT studies on the effect of the nature of the aryl halide Y-C6H4-X on the mechanism of its oxidative addition to Pd0L versus Pd0L2

King Chung Lam; Todd B. Marder; Zhenyang Lin

Chemistry: A European Journal | 2006

Synthesis of heterobimetallic Ru-Mn complexes and the coupling reactions of epoxides with carbon dioxide catalyzed by these complexes.

Man Lok Man; King Chung Lam; Wing Nga Sit; Siu Man Ng; Zhong-Yuan Zhou; Zhenyang Lin; Chak Po Lau

Organometallics | 2010

Mechanism of the Palladium-Catalyzed Borylation of Aryl Halides with Pinacolborane

King Chung Lam; Todd B. Marder; Zheyang Lin

Inorganic Chemistry | 2004

Structural analysis of five-coordinate transition metal boryl complexes with different d-electron configurations.

King Chung Lam; Wai Han Lam; Zhenyang Lin; Todd B. Marder; Nicholas C. Norman

Polyhedron | 2004

Reactions of hydroborating reagents with phosphinorhodium hydride complexes: molecular structures of a Rh2B3 metallaborane cluster, an L2Rh(η2-H2BR2) complex and a mixed valence rh dimer containing a semi-bridging Bcat(cat = 1,2-O2C6H4) group

Stephen A. Westcott; Todd B. Marder; R.Thomas Baker; Richard L. Harlow; Joseph C. Calabrese; King Chung Lam; Zhenyang Lin

Organometallics | 2003

Cp2ZrCH(SiMe3)CCCH(SiMe3): A five-membered 1-zirconacyclopent-3-yne?

King Chung Lam; Zhenyang Lin

Organometallics | 2007

DFT Studies of β-Boryl Elimination Processes: Potential Role in Catalyzed Borylation Reactions of Alkenes

King Chung Lam; and Zhenyang Lin; Todd B. Marder

Dalton Transactions | 2004

Theoretical study of reaction pathways for the rhodium phosphine-catalysed borylation of C?H bonds with pinacolboraneElectronic supplementary information (ESI) available: Figs. S1?S5: Selected structural parameters calculated for the reactive species discussed in the text. Cartesian coordinates of optimised structures. See http://www.rsc.org/suppdata/dt/b4/b402632b/

Wai Han Lam; King Chung Lam; Zhenyang Lin; Shigeru Shimada; Robin N. Perutz; Todd B. Marder

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