Kiriakos Daniilidis

Positive side effects of Ca antagonists for osteoarthritic joints—results of an in vivo pilot study

BackgroundWe have shown previously that some calcium antagonists inhibit hyaluronan export, loss of proteoglycans, and degradation of collagen from osteoarthritic cartilage. Clinically approved calcium antagonists normally are prescribed for cardiac arrhythmia. In the present study, we compared the effect of these drugs on osteoarthritic patients which had received no medication and patients which were also diagnosed for cardiac arrhythmias and were treated with calcium antagonists. The effects and the side effects of the used drugs were analyzed.MethodWe used the Lequesne questionnaire to examine patients with osteoarthritis (212 patients, control group receiving no calcium antagonists) and patients with cardiac arrhythmia and osteoarthritis (188 patients treated with various calcium antagonists). The answers of the questionnaires were transformed into the Lequesne scoring system quantifying the severity of the disease. The Lequesne score is a standardized questionnaire focused on osteoarthritis. It is a 24-scale questionary in which low scores indicate low functional activity.ResultsThe data showed that the mean score of the control group (6.2) was higher than the treated group (5.2), the drugs differed in their efficiency. Verapamil had a slightly worse score and Azupamil, Escor, Felodipine, and Nifedipine showed no alteration. Adalat, Amlodipine, Carmen, Nitrendipin, and Norvasc lead to an improvement.ConclusionThese results suggest that inhibition of hyaluronan export may have a beneficial effect on human osteoarthritis.

Sagittal plane kinematics of fixed- and mobile-bearing total knee replacements

PurposeThe objective of this prospective, randomized, patient- and observer-blinded study was to analyze, in vivo, the knee joint kinematics in the sagittal plane in a patient population that had received either a fixed or a mobile TKA.MethodsThirty-one patients (57 knees) were evaluated by means of fluoroscopy during unloaded flexion and extension against gravity as well as during step up and step down with full weight bearing. In these 31 patients, 22 fixed-bearing TKAs, 16 mobile-bearing TKAs, and 19 natural knee joints were included. Fluoroscopic radiographs were evaluated by measuring the “patella tendon angle” in relation to the knee flexion angle, as a measure of anteroposterior translation, as well as the “kinematic index,” as a measure of reproducibility.ResultsDuring unloaded movement, fluoroscopic analysis did not show a significant difference between both types of prosthesis design and the natural knee. In the weight-bearing movement, both types of TKA designs revealed a more linear patellar tendon angle curve, with a greater angle in extension and in flexion than in the natural knees. In the mobile-bearing group, interindividual deviations from the mean during weight-bearing movements were significantly less than in the fixed-bearing group.ConclusionsNo functional advantage of mobile-bearing TKA over fixed-bearing devices could be found. Both TKA designs showed the typical kinematics of an anterior instability. These results only apply to cruciate retaining mobile-bearing TKA with a bearing that allows both rotation and anteroposterior translation, using a sagittal plane kinematics analysis evaluated by such methodology. A possible influence of less variability of the kinematic pattern on clinical results still needs to be confirmed.Level of evidenceProspective comparative study, Level II.

Expression of Vascular Endothelial Growth Factor on Chondrocytes Increases with Osteoarthritis - An Animal Experimental Investigation

Objective: To evaluate the expression of VEGF by chondrocytes of hyaline cartilage during the course of osteoarthritis (OA). Methods: In 12 white New Zealand rabbits the anterior cruciate ligament (ACL) was resected to create an anterior instability of the knee. In 12 control rabbits only a sham operation without resection of the ACL was done. Four animals of each group were killed at 3, 6, and 12 weeks. The load bearing area was evaluated histologically according to Mankin and by immunostaining for VEGF. Results: In the experimental group, histological grades of OA showed a positive linear correlation with the time after surgery. Immunostaining showed an increased expression of VEGF in the control group after 3 weeks, which dropped to normal after 6 weeks. There was no difference in the progression of OA between control and experimental groups after 3 weeks, but a significant difference was seen after 6 (p=0,01) and 12 (p=0,05) weeks. A significant positive correlation between VEGF expression and the histological grade of OA was found (r = 0.767; p<0.01). Conclusions: An increase of VEGF expressing chondrocytes occurs during time course of OA.

Early results using a biodegradable magnesium screw for modified chevron osteotomies: MG SHORT TERM

This is the first larger study analyzing the use of magnesium‐based screws for fixation of modified Chevron osteotomies in hallux valgus surgery. Forty‐four patients (45 feet) were included in this prospective study. A modified Chevron osteotomy was performed on every patient and a magnesium screw used for fixation. The mean clinical follow up was 21.4 weeks. The mean age of the patients was 45.5 years. Forty patients could be provided with the implant, in four patients the surgeon decided to change to a standard metallic implant. The AOFAS, FAAM and pain NRS‐scale improved markedly. The hallux valgus angle, intermetatarsal angle and sesamoid position improved significantly. Seven patients showed dorsal subluxation, rotation or medial shifting of the metatarsal heads within the first 3 months. One of these patients was revised, in all others the findings were considered clinically not significant or the patients refused revision. This study shows the feasibility of using magnesium screws in hallux valgus‐surgery. Surgeons starting with the use of these implants should be aware of the proper handling of these implants and should know about corrosion effects during healing and its radiographic appearance.

Influence on Therapeutic Decision Making of SPECT-CT for Different Regions of the Foot and Ankle

Background. Single-photon emission computed tomography and computed tomography (SPECT-CT) has a high impact on diagnosis and treatment decision of different joints. The aim of this study was to evaluate whether there is a different gain of SPECT-CT for different foot regions. Material and Methods. We retrospectively identified 86 patients who received a SPECT-CT of the foot and ankle between April 2011 and December 2012. We divided all patients into the following subgroups: ankle (group 1), subtalar (group 2), Chopart (group 3), and Lisfranc (group 4). The local ethical committee approved the study. Results. The clinical treatment decision was changed based on SPECT-CT results in 64.5% of group 1, 65.2% of group 2, and 75% each of groups 3 and 4. Eighty patients (93%) had pain relief after treatment based on SPECT-CT. The overall SPECT-CT sensitivity was 0.94 and the specificity was 0.57. The positive and negative predictive values were 0.87 and 0.75, respectively. Conclusion. The impact of SPECT-CT on treatment decision is slightly higher in diseases of the Chopart and Lisfranc joints than in the upper ankle and subtalar joints. The additional information has a clinical relevance due to the high rate of pain relief by treatment based on SPECT-CT diagnosis.

Operative Treatment of the Insertional Achilles Tendinopathy Through a Transtendinous Approach.

Background: Different operative techniques have been proposed for the treatment of insertional Achilles tendinopathy (IAT), with often disappointing results. The aim of this study was to evaluate the outcome of the transtendinous approach in IAT. Methods: Forty patients operated with an IAT between 2010 and 2011 were included in this retrospective study. The mean follow-up was 15.6 (±3.7, 12-27) months. Indication for surgery was IAT with failed conservative therapy. Using a transtendinous approach, the Achilles tendon (AT) was partially detached and all pathologic tissues were debrided. The AT was reinserted using different anchor techniques. Clinical data were recorded using examination and clinical scores (American Orthopaedic Foot & Ankle Society [AOFAS], Foot and Ankle Outcome Score [FAOS], Numerical Rating Scale [NRS], and Short Form-36 [SF-36]). Results: The mean AOFAS hindfoot score improved from 59.4 preoperatively to 86.5 postoperatively (P < .05). All FAOS subscales, NRS pain scores, and pain and function subscales of SF-36 improved significantly. The median time of return to work and sports was 14.5 (±17.6; 2-82) and 22.7 (±13.4; 7-58) weeks. Three patients had superficial wound healing difficulties but required no revision. One patient had to be revised due to a hematoma. Patients treated with 2 suture anchors or double-row fixation technique improved significantly (P < .05) compared to those with single anchor fixation, regarding AOFAS score (79.6 and 90.2) and FAOS subscale scores. Eighty-three percent of the patients showed good to excellent results. Conclusion: The transtendinous approach allowed access to all associated pathologies in IAT. It had relatively few complications and lead to good clinical results. Level of Clinical Evidence: Level IV, retrospective case series.

Placement of Plantar Plates for Lapidus Arthrodesis Anatomical Considerations

Background: The modified Lapidus procedure is an accepted treatment option for patients with moderate to severe hallux valgus. Placing a plate plantar on the tension side of the arthrodesis has been shown to be biomechanically superior and has provided good clinical results. There is some concern about interference of the plantar placed plates on the tendon insertions. The purpose of this study was to determine a “safe zone” for plantar plate placement without irritation of the tendons. Methods: Twenty-nine embalmed right feet were used for this study. The anatomy of the insertion of the peroneus longus (PL) tendon and tibialis anterior (TA) tendon on the medial cuneiform and first metatarsal were analyzed. Six different plate designs for plantar plating of the first tarsometatarsal fusion were included. The fit to the bone and contact to tendon insertion were analyzed. Results: The PL showed a main insertion to the first metatarsal and a lesser insertion to the medial cuneiform. The TA inserted onto the medial cuneiform and first metatarsal in all cases in our series. There was a “safe zone” between the TA and PL insertion areas for plate placement. Straight, Y- and U-shaped plates could be placed without compromising the tendon insertion. Depending on the design, even preshaped plates may have to be bent to allow a good fit to the plantar side of the first tarsometatarsal joint. Conclusion: Plantar plating for modified Lapidus arthrodesis can be safely performed, without damaging the plantar tendon insertion area of the PL and TA. Clinical Relevance: The exact knowledge of the anatomy of the plantar region of the tarsometatarsal joint can help to improve plate placement.

Femoro-tibial kinematics after TKA in fixed- and mobile-bearing knees in the sagittal plane

PurposeLack of the anterior cruciate ligament in total knee arthroplasty results in paradoxical movement of the femur as opposed to the tibia under deep flexion. Total knee arthroplasty with mobile-bearing inlays has been developed to provide increased physiological movement of the knee joint and to reduce polyethylene abrasion. The aim of this study was to perform an in vitro analysis of the kinematic movement in the sagittal plane in order to show differences between fixed- and mobile-bearing TKA in comparison with the natural knee joint.MethodsSeven knee joints of human cadaver material were used in a laboratory experiment. Fixed- and mobile-bearing inlays were tested in sequences under isokinetic extension in so-called kinemator for knee joints, which can simulate muscular traction power by the use of hydraulic cylinders, which crossover the knee joint. As a target parameter, the a.p. translation of the tibio-femoral relative movement was measured in the sagittal plane under ultrasound (Zebris) control.ResultsThe results show a reduced tibial a.p. translation in relation to the femur in the bearing group compared to the natural joint. In the Z-axis, between 110° and 50° of flexion, linear movement decreases towards caudal movement under extension. Admittedly, the study did not show differences in the movement pattern between “mobile-bearing” and “fixed-bearing” prostheses.ConclusionResults of this study cannot prove functional advantages of mobile-bearing prostheses for the knee joint kinematic after TKA. Both types of prostheses show typical kinematics of an anterior instability, hence they were incapable of performing physiological movement.

Tibiotalocalcaneal Arthrodesis Using a Retrograde Intramedullary Nail with a Valgus Curve

Many different techniques have been described for performing tibiotalocalcaneal arthrodesis (TTCA) in patients with severe hindfoot disorders such as failed ankle arthroplasty and failed ankle joint arthrodesis with subsequent subtalar arthritis. The use of straight retrograde intramedullary nails is extremely limited because they may interfere with normal heel valgus position and risk damaging the lateral plantar neurovascular structures. Curved retrograde intramedullary nails have been designed to overcome these shortcomings. The purpose of this single surgeon series was to investigate the outcomes of TTCA using a curved retrograde intramedullary nail.

Comparison between conservative and surgical treatment of midshaft clavicle fractures: Outcome of 151 cases

INTRODUCTION Midshaft clavicle fractures comprise up to 15% of all adult upper extremity fractures and account for 76% of all clavicle fractures. The treatment of choice remains controversial. The aim of our retrospective study was to compare the outcome of the surgical and conservative procedure in a trauma care unit (single center study). MATERIAL AND METHODS In a cohort of 151 (mean age 36,1y/male 115/female 36) cases, between 2005 and 2009, 70 patients (46.4%) were treated conservatively (mean age 40.8y) and 81 (53.6%) underwent either surgical treatment with a locking compression plate (n=73/mean age 40.3y) or an intramedullary nail system (n=8, mean age 27.1y). Mean follow up was 15 months. Nine patients (5.9%) were lost to follow-up, due to poor compliance. The clinical outcome was assessed by the Disability of Arm, Shoulder and Hand (DASH) score and the Constant shoulder score. RESULTS The average DASH score was 7.3 and the Constant score measured 91.7 in the surgical group. The conservative group achieved a DASH score of 11.1 and a Constant score of 88.1. The clinical scores showed a significant superiority for the benefit of the surgical treatment for the DASH (p=0.037) and Constant score (p=0.036). Totally nine patients had a non-union in the conservative group and six a hardware failure in the surgical group which were revised. DISCUSSION The treatment options for midshaft clavicle fractures have to be discussed carefully for each patient with regard to the non-union risk, function, cosmesis and revision surgery. CONCLUSION Both therapeutic modalities demonstrated comparable efficacy. For active and younger patients we would favour a surgical treatment due to the short time of rehabilitation, the return to sport activities and the high non-union rate after conservative treatment.