Kirsten Bjergarde
Aventis Pharma
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Publication
Featured researches published by Kirsten Bjergarde.
Journal of Medicinal Chemistry | 2015
Jean-Christophe Carry; François Clerc; Hervé Minoux; Laurent Schio; Jacques Mauger; Anil Nair; Eric Parmantier; Ronan Le Moigne; Cécile Delorme; Jean-Paul Nicolas; Alain Krick; Pierre-Yves Abecassis; Véronique Crocq-Stuerga; Stéphanie Pouzieux; Laure Delarbre; Sébastien Maignan; Thomas Bertrand; Kirsten Bjergarde; Nina Ma; Sylvette Lachaud; Houlfa Guizani; Rémi Lebel; Gilles Doerflinger; Sylvie Monget; Sébastien Perron; Francis Gasse; Odile Angouillant-Boniface; Bruno Filoche-Romme; Michel Murer; Sylvie Gontier
The Aurora family of serine/threonine kinases is essential for mitosis. Their crucial role in cell cycle regulation and aberrant expression in a broad range of malignancies have been demonstrated and have prompted intensive search for small molecule Aurora inhibitors. Indeed, over 10 of them have reached the clinic as potential anticancer therapies. We report herein the discovery and optimization of a novel series of tricyclic molecules that has led to SAR156497, an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy. We also provide insights into its mode of binding to its target proteins, which could explain its selectivity.
Archive | 2008
Kirsten Bjergarde; Anil Nair; Marcel Patek; Martha Ackerman-Berrier; Martin Smrcina; Eric Bacque; Michel Tabart; Baptiste Ronan; Vincent Leroy; Fabrice Viviani; Mark Dodson; Catherine Souaille
Archive | 2006
Jacques Mauger; Anil Nair; Nina Ma; Kirsten Bjergarde; Bruno Filoche-Romme; Odile Angouillant-Boniface; Serge Mignani; Cécile Combeau; Jean-Christophe Carry; François Clerc; Hervé Minoux; Laurent Schio
Archive | 2011
Kirsten Bjergarde; Mark Dodson; Jacques Mauger; Anil Nair; Marcel Patek; Michel Tabart
ACS Combinatorial Science | 2004
Marcel Patek; Pavel Safar; Martin Smrcina; Eric Wegrzyniak; Kirsten Bjergarde; and Aleksandra Weichsel; Peter Strop
Archive | 2006
Henning Steinhagen; Jochen Huber; Kurt Ritter; Bernard Pirard; Kirsten Bjergarde; Marcel Patek; Martin Smrcina; Linli Wei
Archive | 2011
Jacques Mauger; Anil Nair; Nina Ma; Kirsten Bjergarde; Bruno Filoche-Romme; Odile Angouillant-Boniface; Serge Mignani; Jean Christophe Carry; Francoise Clerc; Hervé Minoux; Schio Laurent; Cécile Combeau
Archive | 2007
Kirsten Bjergarde; Mark Dodson; Jacques Mauger; Anil Nair; Marcel Patek; Michel Tabart
Archive | 2007
Kirsten Bjergarde; Mark Dodson; Jacques Mauger; Anil Nair; Marcel Patek; Michel Tabart
Archive | 2006
Kirsten Bjergarde; Anil Nair; Marcel Patek; Mark Dodson; Martha Ackerman-Berrier; Martin Smrcina; Vincent Leroy; Eric Bacque; Michel Tabart; Baptiste Ronan; Fabrice Viviani; Catherine Souaille
