Kirsten E. Fleischmann

Myocarditis in Patients Undergoing Treatment with Immune Checkpoint Inhibitors

Immune checkpoint inhibitors (ICI) are novel agents that help target immune responses toward cancer cells. A retrospective registry from eight

A 0/1-Hour Protocol to Assess for Non–ST-Segment Elevation Myocardial Infarction

A protocol has been proposed to assess patients for non–ST-segment elevation myocardial infarction (NSTEMI), based on high-sensitivity troponin T

Percutaneous Coronary Intervention for Patients with Stable Angina

Percutaneous coronary intervention (PCI) is used commonly to ameliorate symptoms in patients with stable angina, but what if part of its effectiveness

Computed Tomography Angiography vs. Functional Stress Testing for Suspected Coronary Artery Disease

Computed tomography angiography (CTA) can detect anatomic coronary disease, whereas stress testing provides functional evidence of ischemia. But how do

Functional Testing to Reduce Unnecessary Angiography

Patients with suspected coronary heart disease (CHD) and a high pretest probability (PP) of disease often undergo invasive angiography, but can

Does CPAP Prevent Adverse CV Events in Patients with Obstructive Sleep Apnea

Patients with obstructive sleep apnea (OSA) are at excess risk for adverse cardiovascular (CV) events. In 2016, two new studies shed light on the

Sex Differences in Functional Stress Testing vs. Computed Tomographic Angiography

In the previously published PROMISE trial, approximately 10,000 patients with stable symptoms suggestive of coronary ischemia were randomized to either functional testing (a stress test of the clinicians choice) or anatomic testing (computed tomographic angiography [CTA]; positive tests were defined as stenosis ≥70%). The overall study demonstrated similar outcomes for the two groups (NEJM JW Gen Med Apr 15 2015 and N Engl J Med 2015; 372:1291), but the investigators did not …

Testing for Coronary Artery Disease in Patients with New-Onset Heart Failure

How often are patients who are admitted with new-onset heart failure (HF) tested for ischemic coronary artery disease (CAD)? Using claims data from 2010 to 2014, investigators analyzed 67,161 patients with new-onset HF, continuous insurance coverage, and 90-day follow-up data. More than half of the cohort had diagnoses of CAD at before their initial HF hospitalizations. Only 17.5% of …

Computed Tomography Angiography or Myocardial Perfusion Imaging in Acute Chest Pain

We have long used stress myocardial perfusion imaging (MPI) to risk-stratify patients with acute chest pain, but computed tomography angiography (CTA)

Benznidazole for Chronic Chagas Cardiomyopathy

Trypanosoma cruzi can cause both acute disease and a more chronic cardiomyopathy. To find out whether trypanocidal therapy kills the parasite or