Kishimura Masaaki

Liposome-Based Immunoassay for Complement Activity and its Application to Clinical Tests

Many types of immunoassays have widely been used for analysis at low concentrations. These methods, however, needs many time-consuming steps for measurements. Recently homogeneous immunoassays in which the complement system lyses liposomes coated with either antigens or antibodies have been developed as reviewed by Monroe[l]. In a previous paper [2] we reported that rabbit 7-globulin (RGG)-coupled liposomes lysed without addition of anti-RGG antibody, and the lysis was extremely enhanced with addition of anti-RGG antibody.