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The Annals of Thoracic Surgery | 1992

A study on optimal temperature for isolated lung preservation

Kembu Nakamoto; Masazumi Maeda; Kiyohide Taniguchi; Noriyuki Tsubota; Yasunaru Kawashima

Fifty-two heart-lung blocks (grafts) of New Zealand white rabbits were used for determining optimal temperature in lung preservation. Grafts were inflated with room air and preserved by simple surface cooling at arbitrarily determined temperatures for 18 hours. Graft function was assessed by nonrecirculated perfusion with autologous blood. Segmented regression models between functional parameters and preservation temperature (T) were applied for determining optimal temperature. Graft ability was also assessed from the point of view of pulmonary circulation by indocyanine green dilution rate of effluent and histological distribution of carbon particles. Significant segmented regression curves and lines between parameters of effluent oxygen tension (PO2) and wet-dry weight ratio (W/D), and T were obtained as follows: PO2 = 150/(1 + 3208.1[e-1.17T]), p less than 0.01; PO2 = -13.8T + 222.6, p less than 0.05; W/D = 5.0 + 1.5/(1 + 0.0028[e0.94T]), p less than 0.01; W/D = 0.075T + 4.52, p less than 0.05. Optimal temperature for lung preservation by topical cooling was calculated as 8 degrees to 9 degrees C from each intersecting point of regression equations. Analysis of regression curves suggested that the most common hypothermic ischemic injury during preservation by topical cooling is pulmonary vascular obstruction, which might be induced at temperatures lower than the critical temperature of 6 degrees to 7 degrees C. Indocyanine green dilution rate and histological findings supported the results of graft functional parameters.


The Journal of The Japanese Association for Chest Surgery | 1992

Blood coagulation and fibrinolysis after surgery for lung cancer

Noriyuki Tsubota; Mitsunori Ohta; Kiyohide Taniguchi; Eiichi Hayashi; Hitoshi Kawaguchi; Kiyorni Nii; Kembu Nakamoto; Kenji Nakamura; Yoshikazu Ikeda; Akira Miyauchi; Masazumi Maeda; Kouichi Kawanishi

肺は凝固線溶能の高い臓器である.肺に外科的侵襲の加わる肺癌術後の血液凝固線溶能について検討した.術前凝固線溶能に異常を認めない手術例55例を対象とした.肺癌22例, 胃癌7例, 胆石症9例, 甲状腺癌7例, 乳癌10例である.術前と術後2, 4, 6, 10, 14, 21病日に血中フィブリノーゲン値, AT-III値, FDP 値を測定した. (1) 疾患群間の比較 : フィブリノーゲン値は肺癌群と胃癌群が他群に比べ術後4, 6病日に有意に上昇した (p<0.05).AT-III値は肺癌群が術後2病日に有意に低下した (p<0.01).FDP値は胃癌群が術後6病日に有意に上昇した (p<0.01). (2) 肺癌群での検討 : 術後2病日のAT-III値 (%) と手術時間 (分) には有意な回帰式 (Y=-0.195X+123.908R=0.854 p<0.01) が得られた.出.血量, 切除量と各測定因子問の有意な関連は認めなかった.肺癌術後はAT-III値の低下を特徴とする凝固線溶能の亢進を認めた.凝固線溶能亢進の因子として, 出血量, 切除量よりも手術時間が関与していた.


Haigan | 1991

A Case Report Suggesting the Significance of Serum CEA in Evaluation of Anticancer Effects.

Kiyohide Taniguchi; Noriyuki Tubota; Hitoshi Kawaguchi; Eiichi Hayashi; Kembu Nakamoto; Masazumi Maeda

症例は74歳男性.1期肺腺癌術後肝転移に対し, rhG-CSF併用chemotherapy (MVP療法: CDDP 80mg/m2, VDS 3 mg/m2, MMC 3mg/m2, 2週間隔, 5クール) で画像上PR (Pertial Response) を得た.化療中のCEA値を経時的に測定した結果, 腫瘍体積と有意の相関をみた.画像上PRであったがCEA値は完全に正常化した.このことは, 縮小した塊状影が腫瘍の壊死組織である可能性を示している.本症例の血清CEA値は, 予後判定のうえで再発の指標となり, 抗腫瘍効果のマーカーとして鋭敏に反応した.血清CEA値は画像診断の限界を補う新たな化療効果判定方法になりうることが示唆された.


Haigan | 2000

Three Surgical Cases of Bronchogenic Carcinoma with Coexisting Active Pulmonary Tuberculosis.

Noriyuki Tsubota; Kiyohide Taniguchi


The Journal of The Japanese Association for Chest Surgery | 1993

Clinical experience with percutaneous cardiopulmonary support system (PCPS) for resection of pulmonary metastasis afterpneumonectomy for lung cancer

Noriyuki Tsubota; Masazumi Maeda; Kohtaro Kameyama; Ayanori Sugita; Eiichi Hayashi; Hitoshi Kawaguchi; Kiyohide Taniguchi; Takahiro Okada; Hiroshi Katsura; Kembu Nakamoto; Norio Nasu; Yuji Miyamoto; Hikaru Matsuda


The Journal of The Japanese Association for Chest Surgery | 2000

Two cases of surgically treated pneumothorax complicating mechanical ventilation

Noriyuki Tsubota; Kiyohide Taniguchi


Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1999

A CASE OF SOLITARY BRAIN AND SOLITARY LUNG METASTASES OCCURRED 13 YEARS AFTER AN OPERATION FOR ADENOCARCINOMA OF THE LUNG

Noriyuki Tsubota; Hideyuki Tanabe; Ryohei Higashi; Hiroko Kuwabara; Kiyohide Taniguchi


Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1999

A CASE OF POSTOPERATIVE RECURRENT INTESTINAL LEIOMYOBLASTOMA WITH PERITONEAL DISSEMINATION

Noriyuki Tsubota; Hideyuki Tanabe; Hisashi Tsuji; Kiyohide Taniguchi; Hiroko Kuwabara


Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1997

A CASE OF PULMONARY DIROFILARIASIS

Noriyuki Tsubota; Hideaki Shimozuma; Hideyuki Tanabe; Kiyohide Taniguchi


Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1997

A case of carcinosarcoma of the breast

Noriyuki Tsubota; Hideyuki Tanabe; Kiyohide Taniguchi

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