Kiyohito Shibata

Bacteria in Bile and Their Role in Postoperative Inflammatory Complications in Biliary Disease

Some hypotheses have been proposed regarding the mechanisms of development of postoperative infections in cases of gallstone disese or malignant disese of the bile duct. Infections are undoubtedly related to the presence of bacteria in bile collected during surgical procedures.

Clinical Studies on Changes in Serum Glycoproteins in Cancer Chemotherapy

Serum glycoproteins of patients with cancer(α1 — Acidglycoprotein, α1 -Antitrypsin, α2-Haptoglobin, α2-Ceruloplasmin) were determined with the Immunoassay Partigen method and the values were observed to be remarkably higher than those patients with benign diseases. Further, it was noted that these values tended to increase with the progress of tumor. Accordingly, it was considered that the progress of cancer could be comprehended objectively through the changes of the values of serum glycoproteins and that these changes might be helpful for the evalation of the effect of anticancer agents administered. Besides, these serum glycoproteins might be a material coating lymphocytes, closely associated with immunoinsufficiency found in patients with cancer. The number of cancer patients examined was 108 in total, which included 33 cases of stomach cancer, 33 cases of colon and rectal cancer, 22 cases of liver, biliary and pancreatic cancer, 8 cases of breast cancer, 5 cases of lung cancer, 6 cases of malignant lymphoma. On the other hand, the benign diseases included 14 cases of gastric, duodenal and cholelithiasis. Classification of the changes of values of alpha,-AG by the disease revealed that in benign diseases they ranged between 40 to 70 mg/dl, remaining almost normal, while in the case of stomach cancer, colon and rectal cancer, they showed a stairlike increase in accordance with the groups aggravating from radical operation group ( A ), palliative operation’s group ( B ) and inoperable cases ( C ).

The Significance of Reduction Surgery in the Treatment of Advanced Cancer Patients

It is generally recognized that patients with advanced or recurrent cancer usually come to their terminal stage without any effective and active treatment. This is because these types of patients show little response to any chemotherapy and radiotherapy on account of their deteriorated general condition and insufficient immunological tolerance.

Thiamphenicol Levels in Human Bile in the Presence of Biliary Tract Diseases

In the present study, the levels of thiamphenicol glycinate in bile and serum were determined in 37 patients following its intravenous administration in a dose of 1g.