Kiyonori Kuromaru

Benzopyran-4-carboxamide K+ channel openers

Abstract N -Substituted benzopyran-4-carboxamides 5 have been synthesized. Some of these compounds exhibited potent vasorelaxant activity.

Structure-activity relationships of 6-substituted benzopyran-4-carbothioamide potassium channel openers.

Abstract QSAR study of 6-substituted benzopyran-4-carbothioamides 1 showed that vasorelaxant activity is linearly correlated with the electronic parameter (σ m ) and parabolically correlated with steric ( L ) and hydrophobic (π) parameters of the 6-substituent.

SYNTHESES OF NOVEL NUCLEOSIDE DIMER ANALOGUES CONTAINING AN ACYCLIC NUCLEOSIDE AND A CARBAMATE LINKAGE

Abstract Novel acyche nucleoside analogues 10 were synthesized and successfully incorporated into heterolytic nucleoside dimers 1–3 containing natural nucleosides and a carbamate linkage.

Vasorelaxant activity of 2-substituted 6-nitro-2H-1-benzopyran-4-carbothioamide K+ channel openers

Abstract Synthesis and vasorelaxant activity of 2-substituted 6-nitro-2 H -1-benzopyran-4-carbothioamides 5 are described. Potent smooth muscle relaxant activity was displayed by 5c , 5h , and 5i .