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Featured researches published by Kiyoshi Hiraki.


Cancer | 1974

Down's syndrome: Establishment of lymphoblastoid cell lines with trisomy 21

Isao Miyoshi; Shuko Yoshimoto; Sunao Fujiwara; Kiyoshi Hiraki; Shunsuke Kimura

Three continuously growing lymphoblastoid cell lines were established from peripheral blood of 3 of 16 patients with Downs syndrome (DS). All these cultures revealed the presence of chromosome constitution of trisomy 21 and Epstein‐Barr virus (EBV) particles. Although EBV capsid antibody levels were generally higher in DS, the frequency of and period to cell line establishment were similar between DS patients and normal individuals.


Cellular and Molecular Life Sciences | 1972

Simultaneous determination of antibody to Epstein-Barr virus in prenatal mothers and new-born infants.

Isao Miyoshi; Harumi Hasegawa; Teruhiko Tsubota; Kiyoshi Hiraki

Antikörpertiter gegen EBV wurden in 40 gepaarten Seren von pränatalen Müttern und Neugeborenen gleichzeitig mit indirekter Immunofluoreszenz bestimmt. In 95% hatten sowohl Mütter als auch Neugeborene den Antikörper. Die Titer der Mütter waren mehrheitlich gleich oder höher jenen der Neugeborenen, woraus geschlossen wird, dass der Antikörper gegen EBV von der Mutter diaplacentar auf den Fetus übertragen werden kann.


Gastroenterologia Japonica | 1972

Studies on etiology and treatment of peptic ulcer

K. Asano; M. Kunisada; T. Utsunomiya; Hirofumi Miyake; S. Yoshimoto; Hideo Harada; Kiyoshi Hiraki

The etiology of peptic ulcer and the mechanisms of action of anti-ulcer agents were investigated by measurement of gastric blood flow. I t has been found that there are differences of blood flow between the regional border of the corpus ana antrum, and between the anterior wall and the posterior wall of corpus. The gastric blood flow was max imum in the anterior wail of corpus and min imum in the antrum. These results suggest that there are the warps of Mood flow between each gastric regions. A change in blood flow occured by some vasoactive agents and anti-ulcer agents. The remarkable increase of blood flow by histamine occured in the corpus with the exception of the lesser curvature. On the other hand, atropine caused a reduction of mucosal blood flow in the corpus. In the group of animals in which acetylcholine was administered, a remarkable increase in blood flow occured at the corpus, especially at the muscular layer of the lesser curvature, I t is known that acetylcholine is closely related to gastric motility, while the effect of histamine closely influences on gastric secretion. These results mean that there are relationship between the gastric Mood flow and gastric functions. Regarding the mechanisms of action of some anti-ulcer agents, a study was made from the standpoint of the relationship between the gastric functions and the variations of blood flow. The effects of anti-ulcer agents on the variations of blood flow between each gastric regions were investigated in the groups of animals which were administered acetylcholine and histamine. It has been found that atropine, scopolamine butylbromide, gefarnate and prostaglandin E x showed the normalizing effects of the variations of blood flow induced by acetylcholine and histamine, whereas the normalizing effect of sulpiride was not significant. On the other hand, proxazole citrate corrected the change of blood flow due to the effect of acetylcholine, while it did not prevent the effect of histamine.


Uirusu | 1966

ELECTRON MICROSCOPIC STUDY ON VIRUS PARTICLES IN MAMMARY CARCINOMAS AND IN THEIR TRANSPLANTS AND CULTURED CELLS IN LOW-CANCER STRAIN MICE

Kiyoshi Hiraki; Zensuke Ota; Isao Miyoshi; Hideo Harada; Shinya Suzuki; Masahito Muguruma

Spontaneous mammary carcinoma of AKR mice and Xray-induced mammary carcinoma of C58 mice, both known as low-cancer strains, were investigated by electron microscopy.In AKR mammary carcinoma, intracytoplasmic type A and extracellular type B particles were present. In C58 mammary carcinoma, extracellular type C particles were observed. In both tumors, mature virus particles, i.e. type B and type C particles, were formed by the process of budding of cytoplasmic membrane of carcinoma cells and present in the lumina of the milk ducts. Aberrant form of type C particles, which contained a filamentous structure instead of a nucleoid was also seen in C58 mammary carcinoma.In serial in vivo transplantation of those carcinoma cells to the same strain mice, these virus particles were always present and formed from carcinoma cells, although the number of virus particles reduced almost successively with transplantations in AKR mammary carcinoma.In tissue culture of C58 mammary carcinoma cells, type C particles similar to those in the original tumor were observed extracellularly. On the contraty to the presence of type B particles in the original AKR mammary tumor, however, two tissue culture strains derived from in vivo transplanted AKR carcinoma cells contained type C particles. These type C particles were conceivable to be the leukemia virus that naturally harbored in AKR mice and happened to have been tranferred to the tissue culture probably through its latent infection in carcinoma cells.


GANN Japanese Journal of Cancer Research | 1963

CELL-FREE TRANSMISSION OF 20-METHYLCHOLANTHRENE-INDUCED RF MOUSE LEUKEMIA AND ELECTRON MICROSCOPIC DEMONSTRATION OF VIRUS PARTICLES IN ITS LEUKEMIC TISSUE

Shozo Irino; Zensuke Ota; Tatsuo Sezaki; Masanori Suzaki; Kiyoshi Hiraki


Acta Medica Okayama | 1958

Studies on diagnosis of leukemia by tissue culture

Kiyoshi Hiraki


Acta Medica Okayama | 1964

Studies on the treatment of malignant tumors with fibroblast-inhibiting agent III. Effects of chloroquine on human cancers

Kiyoshi Hiraki; Ikuro Kimura


Journal of Nutritional Science and Vitaminology | 1977

Vitamin B12 levels of cerebrospinal fluid in patients with a variety of neurological disorders.

Hirokuni Taguchi; Hiroshi Sanada; Koichi Hara; Isao Miyoshi; Kiyoshi Hiraki


Acta Medica Okayama | 1974

Studies on the host-mediated action of the streptococcal preparation, OK-432, in cancer chemotherapy

Ikuro Kimura; Taisuke Onoshi; Shozo Yasuhara; Tatsuo Watanabe; Motoharu Sugiyama; Kiyoshi Hiraki


Acta Medica Okayama | 1963

STUDIES ON THE TREATMENT OF MALIGNANT TUMORS WITH FIBROBLAST-INHIBITING AGENT. I. FIBROBLAST-INHIBITING ACTION OF CHLOROQUINE.

Kiyoshi Hiraki; Ikuro Kimura

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