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Featured researches published by Kiyoshi Hironaga.


Hypertension | 1998

Role of Endogenous Nitric Oxide in the Brain Stem on the Rapid AdaptatKion of Baroreflex

Kiyoshi Hironaga; Yoshitaka Hirooka; Isamu Matsuo; Miwako Shihara; Tatsuya Tagawa; Yasuhiko Harasawa; Akira Takeshita

It has been shown that nitric oxide in the brain stem plays an important role in the control of sympathetic nerve activity. We examined the role of endogenous nitric oxide in the brain stem in the rapid central adaptation of baroreflex control of sympathetic nerve activity in anesthetized rabbits. Bilateral carotid sinuses were isolated, and a stepwise increase in pressure of 25 or 50 mm Hg for 50 to 60 seconds was applied to the carotid sinuses while the arterial pressure and renal sympathetic nerve activity were recorded. The renal sympathetic nerve activity was inhibited by the stepwise increase in carotid sinus pressure, but thereafter it gradually returned toward the baseline level despite the fact that carotid sinus pressure was kept constant. This procedure was performed after intracisternal injection of N(omega)-nitro-L-arginine methyl ester (L-NAME, 8 micromol), N(omega)-nitro-D-arginine methyl ester (D-NAME, 8 micromol), L-arginine (40 micromol), or the vehicle solution. The magnitude of the immediate and maximal inhibition of renal sympathetic nerve activity caused by a stepwise increase in carotid sinus pressure was similar between the vehicle and L-NAME treatment, but the rate of recovery of the renal sympathetic nerve activity after immediate inhibition was faster after L-NAME than after vehicle. L-Arginine reversed the effects of L-NAME. However, D-NAME or L-arginine alone had no such effects on the rate of recovery of the nerve activity. These results thus suggest that endogenous nitric oxide in the brain stem attenuates rapid adaptation of the arterial baroreflex control of the sympathetic nerve activity in rabbits.


Journal of Cardiovascular Pharmacology | 1995

V2 receptor-mediated vasodilation in healthy humans.

Tatsuya Tagawa; Tsutomu Imaizumi; Masanari Shiramoto; Toyonari Endo; Kiyoshi Hironaga; Akira Takeshita

Summary Arginine vasopressin (AVP) causes biphasic changes in vascular resistance in human forearms: vasoconstriction at lower doses and vasodilation at higher doses. Vasoconstriction is mediated by the V1 receptor, but the mechanism of AVP-induced vasodilation remains unclear. To determine if the AVP-induced vasodilation in human forearm vessels is mediated by the V2 receptor, we examined the effects of OPC-31260 (a novel vasopressin V2 receptor antagonist) on AVP-induced vasodilation. The brachial artery was cannulated for drug infusions and direct measurement of arterial blood pressure (BP). We measured forearm blood flow (FBF) by a strain-gauge plethysmograph and calculated forearm vascular resistance (FVR). AVP was infused intraarterially (i.a.) at doses of 0.1, 0.2, 0.5, 1.0, and 2.0 ng/kg/min (n = 8). The lower dose of AVP (0.1 ng/kg/min) increased, whereas the higher doses of AVP (≥0.5 ng/kg/min) decreased, FVR (p < 0.01). Infusion of nitroglycerin (NTG) i.v. doses of 1.7, 3.3, and 10.0 ng/kg/min decreased FVR dose dependently (p < 0.01 ). OPC-31260 (1.0 μg/kg/min) infused i.a. did not alter arteral BP, baseline FVR, or heart rate (HR). OPC-31260 did not affect AVP-induced vasoconstriction but blocked AVP-induced vasodilation completely. OPC-31260 did not affect NTG-induced vasodilation. These results suggest that AVP-induced vasodilation is mediated by the V2 receptor in human forearm resistance vessels.


Arteriosclerosis, Thrombosis, and Vascular Biology | 2017

Ezetimibe in combination with statins ameliorates endothelial dysfunction in coronary arteries after stenting: the CuVIC trial (effect of cholesterol absorption inhibitor usage on target vessel dysfunction after coronary stenting), a multicenter randomized controlled trial

Susumu Takase; Tetsuya Matoba; Soichi Nakashiro; Yasushi Mukai; Shujiro Inoue; Keiji Oi; Taiki Higo; Shunsuke Katsuki; Masao Takemoto; Nobuhiro Suematsu; Kenichi Eshima; Kenji Miyata; Mitsutaka Yamamoto; Makoto Usui; Kenji Sadamatsu; Shinji Satoh; Toshiaki Kadokami; Kiyoshi Hironaga; Ikuyo Ichi; Koji Todaka; Junji Kishimoto; Kensuke Egashira; Kenji Sunagawa

Objectives— We sought to investigate whether treatment with ezetimibe in combination with statins improves coronary endothelial function in target vessels in coronary artery disease patients after coronary stenting. Approach and Results— We conducted a multicenter, prospective, randomized, open-label, blinded-end point trial among 11 cardiovascular treatment centers. From 2011 to 2013, 260 coronary artery disease patients who underwent coronary stenting were randomly allocated to 2 arms (statin monotherapy, S versus ezetimibe [10 mg/d]+statin combinational therapy, E+S). We defined target vessel dysfunction as the primary composite outcome, which comprised target vessel failure during treatment and at the 6- to 8-month follow-up coronary angiography and coronary endothelial dysfunction determined via intracoronary acetylcholine testing performed in cases without target vessel failure at the follow-up coronary angiography. Coadministration of ezetimibe with statins further lowered low-density lipoprotein cholesterol levels (83±23 mg/dL in S versus 67±23 mg/dL in E+S; P<0.0001), with significant decreases in oxidized low-density lipoprotein and oxysterol levels. Among patients without target vessel failure, 46 out of 89 patients (52%) in the S arm and 34 out of 96 patients (35%) in the E+S arm were found to have coronary endothelial dysfunction (P=0.0256), and the incidence of target vessel dysfunction at follow-up was significantly decreased in the E+S arm (69/112 (62%) in S versus 47/109 (43%) in E+S; P=0.0059). A post hoc analysis of post-treatment low-density lipoprotein cholesterol–matched subgroups revealed that the incidence of both target vessel dysfunction and coronary endothelial dysfunction significantly decreased in the E+S arm, with significant reductions in oxysterol levels. Conclusions— The CuVIC trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction after Coronary Stenting) has shown that ezetimibe with statins, compared with statin monotherapy, improves functional prognoses, ameliorating endothelial dysfunction in stented coronary arteries, and was associated with larger decreases in oxysterol levels.


Journal of Arrhythmia | 2017

Clinical benefits of deep sedation with a supraglottic airway while monitoring the bispectral index during catheter ablation of atrial fibrillation

Satoru Hida; Masao Takemoto; Akihiro Masumoto; Takahiro Mito; Kazuhiro Nagaoka; Hiroshi Kumeda; Yuki Kawano; Ryota Aoki; Honsa Kang; Atsushi Tanaka; Atsutoshi Matsuo; Kiyoshi Hironaga; Teiji Okazaki; Kiyonobu Yoshitake; Keiichiro Tayama; Kenichi Kosuga

Pulmonary vein antrum isolation (PVAI) under sedation has proven to be a useful strategy for catheter ablation of atrial fibrillation (AF).


Hypertension | 2001

Possible Involvement of Rho-Kinase in the Pathogenesis of Hypertension in Humans

Akihiro Masumoto; Yoshitaka Hirooka; Hiroaki Shimokawa; Kiyoshi Hironaga; Soko Setoguchi; Akira Takeshita


American Journal of Cardiology | 2001

Effect of pravastatin on endothelial function in patients with coronary artery disease (cholesterol-independent effect of pravastatin)

Akihiro Masumoto; Yoshitaka Hirooka; Kiyoshi Hironaga; Kenichi Eshima; Soko Setoguchi; Kensuke Egashira; Akira Takeshita


American Journal of Physiology-regulatory Integrative and Comparative Physiology | 2001

Glutamate release via NO production evoked by NMDA in the NTS enhances hypotension and bradycardia in vivo.

Isamu Matsuo; Yoshitaka Hirooka; Kiyoshi Hironaga; Kenichi Eshima; Hideaki Shigematsu; Miwako Shihara; Koji Sakai; Akira Takeshita


Hypertension Research | 2002

Long-term treatment with eicosapentaenoic acid improves exercise-induced vasodilation in patients with coronary artery disease.

Tatsuya Tagawa; Yoshitaka Hirooka; Hiroaki Shimokawa; Kiyoshi Hironaga; Koji Sakai; Jun Ichi Oyama; Akira Takeshita


Clinical Science | 1997

Role of Nitric Oxide towards Vasodilator Effects of Substance P and ATP in Human Forearm Vessels

Masanari Shiramoto; Tsutomu Imaizumi; Yoshitaka Hirooka; Toyonari Endo; Takashi Namba; Jun-ichi Oyama; Kiyoshi Hironaga; Akira Takeshita


Internal Medicine | 2007

Left Ventricular False-pseudo and Pseudo Aneurysm: Serial Observations by Cardiac Magnetic Resonance Imaging

Shin-ichi Ando; Toshiaki Kadokami; Hidetoshi Momii; Kiyoshi Hironaga; Natsumi Kawamura; Takaya Fukuyama; Naoki Minato

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