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Kiyoshi Nakayama

Osaka University

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Publication

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Bioorganic & Medicinal Chemistry Letters | 1998

Synthesis and cytotoxic activity of novel 10-alkylated docetaxel analogs.

Kiyoshi Nakayama; Hirofumi Terasawa; Ikuo Mitsui; Satoru Ohsuki; Kouichi Uoto; Shin Iimura; Tsunehiko Soga

An alkylation method of docetaxel at the C-10 position has been established by a radical coupling reaction using a 10-xanthate derivative of 7-O-TES-10-deacetylbaccatin III and appropriate alkenes. In addition the cytotoxic activity of 10-alkylated docetaxel analogs was evaluated. Among these analogs, a derivative having a methoxycarbonyl group at the end of the alkyl moiety exhibited more potent cytotoxic activity than docetaxel.

Chemical & Pharmaceutical Bulletin | 1992

A Useful Method for Deprotection of the Protective Allyl Group at the Anomeric Oxygen of Carbohydrate Moieties Using Tetrakis(triphenylphosphine)palladium

Kiyoshi Nakayama; Kouichi Uoto; Kunio Higashi; Tsunehiko Soga; Tsuneo Kusama

Chemical & Pharmaceutical Bulletin | 1990

Synthesis and antitumor activity of lipid A analogs having a phosphonooxyethyl group with alpha- or beta-configuration at position 1.

Tsuneo Kusama; Tsunehiko Soga; Emiko Shioya; Kiyoshi Nakayama; Hiroto Nakajima; Yasuaki Osada; Yoshiyuki Ono; Shoichi Kusumoto; Tetsuo Shiba

Chemical & Pharmaceutical Bulletin | 1991

Synthesis and Biological Activities of Lipid A Analogs : Modification of a Glycosidically Bound Group with Chemically Stable Polar Acidic Groups and Lipophilic Groups on the Disaccharide Backbone with Tetradecanoyl or N-Dodecanoylglycyl Groups

Tsuneo Kusama; Tsunehiko Soga; Yashiyuki Ono; Eiji Kumazawa; Emiko Shioya; Kiyoshi Nakayama; Uoto Kouichi; Yasuaki Osada

Chemical & Pharmaceutical Bulletin | 1991

Direct transformation of O-glycoside into glycosyl bromide with the combination of trimethylsilyl bromide and zinc bromide

Kunio Higashi; Kiyoshi Nakayama; Emiko Shioya; Tsuneo Kusama

Chemical & Pharmaceutical Bulletin | 1990

Novel Stereoselective Glycosidation by the Combined Use of Trityl Halide and Lewis Acid

Kunio Higashi; Kiyoshi Nakayama; Tsunehiko Soga; Emiko Shioya; Kouichi Uoto; Tsuneo Kusama

Chemical & Pharmaceutical Bulletin | 1992

Synthesis and antiallergy activity of [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives II: 6-alkyl- and 6-cycloalkylalkyl derivatives

Shuichi Yokohama; Tamotsu Miwa; Shunzo Aibara; Hiroyuki Fujiwara; Hiroo Matsumoto; Kiyoshi Nakayama; Teiji Iwamoto; Mikiko Mori; Reimei Moroi; Wataru Tsukada; Sumiro Isoda

Chemical & Pharmaceutical Bulletin | 1991

A NOVEL GLYCOSIDE ANOMERIZATION CATALYZED BY TRIMETHYLSILYL BROMIDE AND ZINC BROMIDE IN COMBINATION

Kunio Higashi; Kiyoshi Nakayama; Kouichi Uoto; Emiko Shioya; Tsuneo Kusama

Chemical & Pharmaceutical Bulletin | 1992

Zinc triflate-promoted glycosidation : synthesis of lipid A disaccharide intermediates

Kiyoshi Nakayama; Kunio Higashi; Tsunehiko Soga; Kouichi Uoto; Tsuneo Kusama

Chemical & Pharmaceutical Bulletin | 1992

Direct Transformation of O-Glycosides into Other O-Glycosides Using Trimethylsilyl Bromide and Zinc Bromide

Kunio Higashi; Kiyoshi Nakayama; Emiko Shioya; Tsuneo Kusama

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Collaboration

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Tsuneo Kusama

University of Tokyo

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Tsunehiko Soga

Osaka University

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Emiko Shioya

Osaka University

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Kouichi Uoto

Hokkaido University

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Shin Iimura

Daiichi Sankyo

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Yasuaki Osada

Osaka University

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Eiji Kumazawa

Osaka University

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Hiroo Matsumoto

Kanazawa University

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Hiroto Nakajima

Osaka University

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Mikiko Mori

Tohoku University

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