Klaus-Dieter Vorlop

New Matrices and Bioencapsulation Processes

A PVA-matrix is presented which is capable of gelating at room temperature resulting in lens-shaped particles (LentiKats®). Immobilisation of biocatalysts in LentiKats® is possible without significant loss of biological activity. The hydrogels are long term mechanically and chemically stable and show hardly any biodegradability.

The Jetcutter Technology

Solid particles (pellets, beads) in the size range between µm and mm play an important role in various industries like biotechnology, agriculture, chemical, pharmaceutical and food industry. Thus, plenty of particle production technologies exist and their further development is of major interest both from the economic and scientific point of view.

Entrapment in LentiKats

In this paper LentiKats® are presented as an efficient and powerful alternative to traditional and established encapsulation carriers.

Immobilization at Large Scale by Dispersion

Producing microcapsules at large scale implies first caring about the dispersion processes. The droplet solidification step (gelation, membrane formation ...) generally brings less problems (reader will refer to Chapter 3). In this chapter, four technologies of producing droplet at large scale will be proposed for cell encapsulation purposes: n n njet breaking methods n n nLentiKat method n n nrotating devices n n nemulsification using static mixers