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Klaus Gubernator

Hoffmann-La Roche

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Publication

Featured researches published by Klaus Gubernator.

Journal of The Chemical Society, Chemical Communications | 1988

Preparation and X-ray crystal structures of two 1-amino-2,6-anhydro-1,3,4-trideoxy-D-erythro- and L-glycero-heptitol derivatives

Klaus Gubernator; Colin H. L. Kennard; Peter Schönholzer; Thomas Weller

The structures of the 1-amino-2,6-anhydro-hepitol derivatives (4) and (6), prepared from nitrile (3), were determined by X-ray crystallography.

Journal of Medicinal Chemistry | 1998

Physicochemical high throughput screening : Parallel artificial membrane permeation assay in the description of passive absorption processes

Manfred Kansy; Frank Senner; Klaus Gubernator

Journal of Medicinal Chemistry | 1994

Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors.

Kurt Hilpert; J Ackermann; David W. Banner; A Gast; Klaus Gubernator; P Hadvary; L Labler; K Muller; G Schmid; T.B. Tschopp

Angewandte Chemie | 1995

Optimization of the Biological Activity of Combinatorial Compound Libraries by a Genetic Algorithm

Lutz Weber; Sabine Wallbaum; Clemens Broger; Klaus Gubernator

Journal of Medicinal Chemistry | 1998

Structure-Based Design of β-Lactamase Inhibitors. 1. Synthesis and Evaluation of Bridged Monobactams

Ingrid Heinze-Krauss; Peter Angehrn; Robert Charnas; Klaus Gubernator; Eva-Maria Gutknecht; Christian Hubschwerlen; Malgosia Kania; Christian Oefner; Malcolm G. P. Page; Satoshi Sogabe; Jean-Luc Specklin; Fritz K. Winkler

Journal of Medicinal Chemistry | 1992

Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors

Christian Hubschwerlen; P. Pflieger; Jean-Luc Specklin; Klaus Gubernator; H. Gmuender; Peter Angehrn; Ivan Kompis

Proteins | 1989

The construction of new proteins: V. A template‐assembled synthetic protein (TASP) containing both a 4‐helix bundle and β‐barrel‐like structure

Manfred Mutter; René Hersperger; Klaus Gubernator; Klaus Müller

Helvetica Chimica Acta | 1988

Generic shapes for the conformation analysis of macrocyclic structures

Paul R. Gerber; Klaus Gubernator; Klaus Müller

Journal of Medicinal Chemistry | 1998

Structure-based design of β-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins

Christian Hubschwerlen; Peter Angehrn; Klaus Gubernator; Malcolm G. P. Page; Jean-Luc Specklin

Angewandte Chemie | 1995

Optimierung der biologischen Aktivität von kombinatorischen Verbindungsbibliotheken durch einen genetischen Algorithmus

Lutz Weber; Sabine Wallbaum; Clemens Broger; Klaus Gubernator

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David W. Banner

Hoffmann-La Roche

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Kurt Hilpert

Hoffmann-La Roche

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Gerard Schmid

Hoffmann-La Roche

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Jean Ackermann

Hoffmann-La Roche

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Christian Hubschwerlen

Hoffmann-La Roche

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Klaus Müller

Hoffmann-La Roche

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Peter Angehrn

Hoffmann-La Roche

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Jean-Luc Specklin

Hoffmann-La Roche

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Malcolm G. P. Page

Hoffmann-La Roche

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Robert Charnas

Hoffmann-La Roche

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