Klaus Hartnegg

Optomotor and neuropsychological performance in old age

While a delayed initiation of visually guided saccades with increasing age has been documented in a number of studies, little research has been done on the control of antisaccades. The present study investigates aging effects on the control of visually guided saccades (prosaccades) and antisaccades as well as a selection of neuropsychological functions by the cross-sectional comparison of 14, 22, and 16 participants aged 20–35 years, 59–73 years, and 74–88 years, respectively. The geriatric and neurological status of the elder participants (including evidence from computed tomography, electroencephalography, and neurological soft signs) was assessed. In four task blocks of 200 trials each, pro- and antisaccades were elicited under the 200-ms-gap and overlap conditions. Left- and right-sided stimuli were presented in random order at 4°, and the order of the task blocks was varied within each age group. In addition, the Wisconsin card-sorting test (WCST) and working memory, go-nogo discrimination, alertness, and stimulus-response incompatibility tests were administered. Participants aged 59–73 years exhibited widespread reductions of optomotor and neuropsychological performance, with greatest effect sizes of age differences in the optomotor parameters and the WCST measures. A further decay after the age of 73 years was discernible in those optomotor functions reflecting saccade disinhibition (in particular, directional errors during the antisaccade task and premature responses) and the performance in some neuropsychological tests. In line with previously published reports, variance in optomotor performance could be explained by two factors, accounting for a total of 76% of the age variance. Our results suggest that the investigation of saccade control may be a highly sensitive tool for neurodevelopmental aging research.

Voluntary Saccadic Control in Dyslexia

The role of eye-movement control in dyslexia is still unclear. Recent studies, however, confirmed that dyslexics show poor saccadic control in single and sequential target tasks. In the present study we investigated whether dyslexic subjects are impaired on an antisaccade task requiring saccades against the direction of a stimulus. Altogether, 620 subjects between the ages of 7 and 17 years were classified as dyslexics (N = 506) or control subjects (N = 114) on the grounds of the discrepancy between their intellectual abilities and reading/spelling achievements. All subjects performed an overlap prosaccade and a gap antisaccade task with 100 trials to each side of stimulation in random order. Variables analysed were the overall saccadic reaction time of both tasks; and from the antisaccade task the number of errors (prosaccades), the number of corrected errors, and the number of trials in which the subjects still failed to reach the side opposite the stimulus even after two saccades. An analysis of variance was carried out taking into account the development of saccadic behaviour with age and the differences between the groups. The results confirm development of saccade control with age, especially in the voluntary component (a frontal-lobe function) for both groups, but indicate that the antisaccade task performance, as measured by the error and the correction rate, is significantly worse in the dyslexic group at ages above 8 years. Up to 50% of the dyslexics performed the antisaccade task 1.5 standard deviations below the mean of the controls.

The analysis of saccadic eye movements from gap and overlap paradigms

This protocol describes the acquisition and evaluation of saccadic eye movement data for use in basic neuroscience research and clinical application. The experimental protocol requires the subject to make saccadic eye movements in response to visual stimuli presented, in random order, on consecutive trials. The gap and overlap paradigms are described together with the instruction to generate pro- or antisaccades. The protocol includes the description of saccade detection, the determination of the beginning, the end, the size, and the velocity of a saccade, the exact way of calculating the proportion of different kinds of trials, and the treatment of erratic or artifact trials. Relevant variables are defined. The results obtained from a large number (300) of subjects of different ages (8-65 years) are described and analysed with respect to their development with age. The protocol allows to test a subjects saccadic status in many different circumstances in particular with respect to diagnostic help in neurology, psychiatry and psychology.

Effects of Visual Training on Saccade Control in Dyslexia

This study reports the effects of daily practice of three visual tasks on the saccadic performance of 85 dyslexic children in the age range of 8 to 15 years. The children were selected from among other dyslexics because they showed deficits in their eye-movement control, especially in fixation stability and/or voluntary saccade control. Their eye movements were measured in an overlap prosaccade and a gap antisaccade task before and after the training. The three tasks used for the training included a fixation, a saccade, and a distractor condition. In any of these tasks, the subject had to detect the last orientation of a small pattern which rapidly changed its orientation between up, down, right, and left, before it disappeared after some time. The task was to press one of four keys corresponding to the last orientation. The visual pattern was presented on an LCD display of a small hand-held instrument given to the children for daily use at home. The results indicate that daily practice improved not only the perceptual capacity, but also the voluntary saccade control, within 3 to 8 weeks. After the training, the group of dyslexics was no longer statistically different from the control group.

Dynamic Visual Perception of Dyslexic Children

This study describes the capacity of children to detect fast changes of a small visual pattern. Three visual detection tasks for a group of normally reading (N = 140) and another group of dyslexic children (N = 366) in the age range of 7 to 16 years have been used. All three tasks require the detection of the fast changing orientation of a small pattern before it disappears. In one task, stationary fixation was required, because the orientation changes took place always at the same location. In the saccade condition, the pattern was displaced suddenly to one or the other side and a saccade was required to detect the orientation. In a third condition, a distractor was presented at one side shortly before the oriented pattern appeared at the opposite side. In this case, an antisaccade with respect to the distractor was required. In all three conditions, the dyslexic group as a whole performed significantly below the level of the control group. The performance improved with age in both groups. The differences between the test and control group were largest in the distractor condition. When compared with eye-movement performance in an antisaccade task, a parallel development of the performance of both tasks was observed in both groups. The study shows that a certain percentage of dyslexic children has difficulties in the perception of fast changing stimuli, a task presumably challenging the magnocellular system.

Stability of gaze control in dyslexia.

The neurobiological basis of saccade control has at least three components: fixation, reflexes, voluntary control. It was found in earlier studies that the voluntary component of saccade is specifically impaired in dyslexics as compared with controls of the same age. In this study, we searched for evidence of fixation instability by analyzing the eye movements of 99 control subjects and 262 dyslexics (age 7-17 years) performing an overlap prosaccade and a gap antisaccade task. The percentage of intrusive saccades was counted for each subject during a period of the trial where stationary fixation was required. Both groups showed improvements of fixation stability with age, but the dyslexic group exhibited developmental deficits. It is discussed whether these deficits could be interpreted as consequences of deficits in the magnocellular pathway.

On the production and correction of involuntary prosaccades in a gap antisaccade task.

In an antisaccade task, where saccades in the direction opposite of a suddenly presented stimulus are required, certain numbers of prosaccades can occur. The hypothesis is put forward that poor fixation and poor voluntary saccade control constitute two independent sources for the errors. This possibility is investigated by including the corrections of the errors in the analysis. First, the eye movements of 346 normal subjects (group N) performing a gap antisaccade and an overlap prosaccade task were measured. For each subject the proportion of express saccades in the overlap prosaccade task and the proportion of prosaccades in the gap antisaccade task were determined. The data of 150 subjects with more than 20% proerrors were divided into two groups: group A with relatively many, group B with relatively few express saccades in the overlap prosaccade task. Group A subjects produced their errors after significantly shorter reaction times and they corrected their errors significantly faster and more often than group B subjects. Second, we analysed the data of three groups of subjects: the complete normal group N, a group D of dyslexic subjects (n=343), and a group T containing all subjects irrespective of their cognitive achievements (n=780). A highly significant negative correlation exists between the correction rates and the error rates. A factor analysis of the variables performed for each group separately results in only two factors, one describing prosaccade the other antisaccade control. Only the error rate contributes significantly to both factors indicating that high errors may have two independent reasons.

A turn-key transportable eye-tracking instrument for clinical assessment

This paper describes a combined instrument (eye tracker and target generator, both head mounted, with integrated data analysis) that tests parameters of saccadic eye movement and fixation control to give insight into the status of functional brain systems. Using three minilasers, the target generator projects three visual stimuli, a fixation point and two lateral stimuli, with programmable timing. The controller allows the selection of overlap, 200-msec gap, or remembered saccade trials. Size, maximal velocity, and reaction time are determined for each primary saccade. The number of prosaccades and antisaccades are counted. More saccades—for example, the occurrence and latency of corrective saccades—may be evaluated off line by an interactive PC analysis program. The eye position data can be transferred to a PC. Off-line analysis compares each observed variable relative to an age-matched control group (300 healthy control subjects 7–70 years of age, tested in the overlap condition with prosaccade instructions and in the gap condition with antisaccades). The diagnostic results can be used to elaborate an individual optomotor training program.

Regression-based developmental models exemplified for Wisconsin Card Sorting Test parameters: statistics and software for individual predictions.

The prediction of an individuals score is relevant in clinical research and requires normative data and a statistical rationale. In the case of developmental research the latter is typically a set of descriptive statistics (e.g., standard scores) for a set of age groups. Here we illustrate a multiple regression approach with a set of 345 Wisconsin Card Sorting Test (WCST) data obtained from subjects aged 6 to 26 years. We modeled linear and curvilinear age effects for each of the 11 WCST variables and, based on this, determined confidence limits for the expected value (mean) and the prediction of individual scores. In these multiple regression models, which accounted for 2% to 26% of the variance, curvilinear age effects clearly dominated linear ones, suggesting the features under scrutiny to be negatively accelerated functions of age. Finally, we developed a statistics program that can be used to apply multiple regression models for individual predictions that are based on normative data with up to 7 predictor variables. We discuss the conditions of applicability of the approach, compare it with the conventional standard score approach, discuss its cognitive-developmental implications, and outline the applicability in applied research and practising.