Klaus Nagels
UCB
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Publication
Featured researches published by Klaus Nagels.
International Journal of Pharmaceutics | 1997
Paul A. Dickinson; Ian W. Kellaway; Glyn Taylor; Detlef Mohr; Klaus Nagels; Hans-Michael Wolff
In vitro 17β-estradiol release from controlled-release microspheres intended for intra-muscular administration was investigated using a rotating bottle apparatus. Prior to intra-muscular administration of 17β-estradiol loaded microspheres the in vivo pharmacokinetics of 17β-estradiol in NZW rabbits were determined: the clearance value was 50.0 ± 8.1 l/d/kg and the elimination half-life was 7.7 ± 2.2 min (n = 6 ± S.D.). The release of 17β-estradiol from the microspheres in vivo was determined and compared to the release profile obtained in vitro using two release protocols. There was a linear relationship from day 0 until day 30 irrespective of which in vitro test protocol was used. It is suggested that the rotating bottle apparatus is a good starting point for the development of an in vitro release test method for controlled-released intra-muscular dosage forms. Possible strategies for the improvement of an in vitro test to predict in vivo release are discussed.
Archive | 1993
Hans P. Merkle; Klaus Nagels; Dietrich Wilhelm Schacht; Hans-Michael Wolff
Archive | 1992
Hans P. Merkle; Klaus Nagels; Dietrich Wilhelm Schacht; Hans-Michael Wolff
Archive | 1993
Hans P. Merkle; Klaus Nagels; Dietrich Wilhelm Schacht; Hans-Michael Wolff
Archive | 1995
Hans P. Merkle; Klaus Nagels; Dietrich Wilhelm Schacht; Hans-Michael Wolff
Archive | 1995
Hans P. Merkle; Klaus Nagels; Dietrich Wilhelm Schacht; Hans-Michael Wolff
Archive | 1993
Hans P. Merkle; Klaus Nagels; Dietrich Wilhelm Schacht; Hans-Michael Wolff
Archive | 1993
Hans P. Merkle; Klaus Nagels; Dietrich Wilhelm Schacht; Hans-Michael Wolff
Archive | 1993
Hans P. Merkle; Klaus Nagels; Dietrich Wilhelm Schacht; Hans-Michael Wolff
Archive | 1993
Hans P. Merkle; Klaus Nagels; Dietrich Wilhelm Schacht; Hans-Michael Wolff