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Dive into the research topics where Koffi Koba is active.

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Featured researches published by Koffi Koba.


Journal of Essential Oil Bearing Plants | 2007

Chemical Composition and in vitro Cytotoxic Activity of Essential Oils from Two Tropical Lamiaceae: Aeollanthus pubescens Benth. and Ocimum gratissimum L

Koffi Koba; Komla Sanda; Catherine Guyon; Christine Raynaud; Joëlle Millet; Jean-Pierre Chaumont; Laurence Nicod

Abstract Essential oils of Aeollanthus pubescens Benth. and Ocimum gratissimum L. (Lamiaceae) from Togo were investigated for their percentage composition and in vitro cytotoxicity. The GC and GC-MS analyses indicated that the major constituents of both essential oils were thymol, p-cymene and γ-terpinene. Testing of these volatile oils and their major constituents from commercial origin in vitro for possible cytotoxicity on the human epidermic cell line HaCat showed that the toxicity of the essential oil of A. pubescens (IC50: 1800µg.ml−1) was higher than that of the essential oil of O. gratissimum (IC50: 2400 µg.ml−1). Pure commercial thymol standard showed a cytotoxicity (IC50: 1800 µg.ml−1) identical to that of the A. pubescens essential oil. Conversely, p-cymene and γ-terpinene standards were found almost non-toxic (IC50 >3000 µg.ml−1). These findings support the assumption that the cytotoxic activities of the tested essential oils were basically due to their high level content in thymol.


Archive | 2011

Ecohealth and Climate Change: Adaptation to Flooding Events in Riverside Secondary Cities, West Africa

Guéladio Cissé; Brama Koné; Hampaté Bâ; Ibrahima Mbaye; Koffi Koba; Jürg Utzinger; Marcel Tanner

In 2009, for the first time in history, more people were found to live in urban areas than in rural settings. Predictions for 2025 are that 70% of the world’s population will be urban. Urban dwellers in particular, then, will need to adapt to climate change. Urbanization occurs at a rapid pace in secondary cities across Africa. Indeed, half the increase of urban populations in the coming years is expected to occur in secondary cities. Poor settlements near water bodies (rivers, irrigation systems and large dams) are prone to flooding, which is likely to be exacerbated by climate change. Employing an ecohealth approach, this study explores the vulnerabilities and resilience of poor urban settlers in four secondary cities of West Africa, all located in close proximity to water bodies: Korhogo, Cote d’Ivoire (212,000 inhabitants, near a dam); Kaedi, Mauritania (71,000 inhabitants, near a river); Ziguinchor, Senegal (269,000 inhabitants, near a river); and Kara, Togo (120,000 inhabitants, near a river). The aim of this study is to reinforce the resilience of the most vulnerable of these communities and their capacity to adapt to processes of drought and flooding in two climatic contexts: semi-arid and tropical humid. Local governance authorities play a central role in this project, which emphasizes participatory research, and explores linkages between hazards, vulnerabilities and local adaptive capacity potentials, particularly in the water and health sectors.


Journal of Essential Oil Research | 2008

Chemical Composition and In Vitro Cytotoxic Activity of Xylopia aethiopica (Dun) A. Rich. (Annonaceae) Fruit Essential Oil from Togo

Koffi Koba; Komla Sanda; Christine Raynaud; Catherine Guyon; Jean-Pierre Chaumont; Laurence Nicod

Abstract Essential oil extracted (4.4% in yield) from air-dried fruits of Xylopia aethiopica harvested in Togo was investigated for percentage composition and in vitro cytotoxicity. The chemical composition of the essential oil was examined by GC and GC/MS. Thirty-five compounds were identified representing 89.9% of total oil. The major constituents were β-pinene (23.6%), α-pinene (11%), sabinene (9.8%), germacrene D (8.3%) and 1,8 cineole (8.2%). The cytotoxicity of the volatile oil was evaluated in vitro on the human epidermal cell line HaCaT. The tested sample did not show any cytotoxicity (IC50 >3000 μg.ml-1) effect at concentrations around 3000 μg.ml-1. Further testing in bioassay would probably help in validating some of medicinal uses of X. aethiopica in topical drugs and/or in cosmetics as natural products.


Journal of Biofertilizers & Biopesticides | 2012

Efficacy of Cymbopogon Schoenanthus L. Spreng (Poaceae) Extracts on Diamondback Moth Damaging Cabbage

Bakouma Laba; Amen Yawo Nenonene; Yao Adjrah; Koffi Koba; Wiyao Poutouli; Komlan Sanda

This study aims to examine the insecticidal properties of the aerial part of Cymbopogon schoenanthus. Cabbage plants were sprayed with the aqueous extracts of C. schoenanthus leaves as treatment, and the damage levels of Plutella xylostella was assessed. In vitro, the emulsified essential oil concentrations were used in a contact test on the larvae in order to assess the mortality effects. The larvae survival time was only 22 seconds with C. schoenanthus emulsified oil treatment (2 g/l), whilst it exceeded 44,100 seconds (over 12 hours) for the dimethoate. The nutrition test showed that at 48 h period, a significant effectiveness against larvae was observed with emulsified oil treatment 2 g/l (60% mortality) versus 10% of mortality for dimethoate. Cymbopogon schoenanthus can validly be used as alternative in P. xylostella management. The results of the field experiments showed no significant difference between the treatments and the control in terms of marketable cabbages harvested.


Acta Botanica Gallica | 2008

Capacités morphogénétiques in vitro, performance au champ et production d'huiles essentielles chez Ocimum gratissimum L.

Atsou Aïdam; Kodjo Djidjolé Etsè; Koffi Koba; Christine Raynaud; Komla Sanda; Jean-Pierre Chaumont; Jocelyne Trémouillaux-Guiller

Abstract Morphogenetic capacities of Ocimum gratissimum were revealed in vitro from nodal segment—derived shoots cultivated with α-naphtalene acetic acid (NAA, 0.54 or 5.37 μM), or indolebutyric acid (IBA, 2.45 μM), or 6-benzylamino- purine (BAP, 0.44 or 4.44 μM) or kinetin (Kin, 0.46 or 4.65 μM). NAA or IBA decreased caulogenesis and slowed down rooting. Both auxins improve growth of the shoots by elongation of the inter-nodes. BAP (4.44 μM) or Kin (4.65 μM) led to bushing shoots. Four months old plantlets (10%) were successfully acclimatized in greenhouse, before being cultured in field. Essential oils were analyzed by simple gas chromatography and coupled with the mass spectrometry. Essential oil efficiencies (EO %) were found to be superior to these of the mother plant and thymol, p-cymene, γ-terpinene and ß-myrcene could be mainly identified in the harvested plants.


Journal of Essential Oil Bearing Plants | 2011

Chemical Composition and Cytotoxic Activity of Essential Oil of Chromolaena odorata L. Growing in Togo

Koffi Koba; Amen Yawo Nenonene; Guyon Catherine; Christine Raynaud; Jean-Pierre Chaumont; Komla Sanda; Nicod Laurence

Abstract The leaf essential oil of Chromolaena odorata L. (Asteraceae) harvested in Togo were steam-distilled and investigated for chemical composition (GC and GC-MS) and in vitro potential cytotoxic activity on human epidermic cell line HaCat. The chemical composition showed that the main constituents of essential oil sample were respectively β-caryophyllene (25.2 %), germacrene D (18.8 %), and linalool (7.9 %). The in vitro cytotoxicity bioassays on human cell line HaCaT did not revealed any toxicity of C. odorata essential oil up to 3000 μL.mL−1. Pure commercial β-caryophyllene and germacrene D standards appeared almost non-toxic (IC50 >3000 μL.mL−1), proving the major role played by the major components in the overall cell viability showed by the C. odorata oil sample tested in this work.


Journal of Essential Oil Research | 2011

Antibacterial Activities of Coleus Aromaticus Benth (Lamiaceae) Essential Oil against Oral Pathogens

Koffi Koba; Amen Yawo Nenonene; Komla Sanda; D. Garde; Joëlle Millet; Jean-Pierre Chaumont; Christine Raynaud

Abstract Leaf essential oil of Coleus aromaticus (Lamiaceae) from Cambodia was steam-distilled and investigated for its percentage composition and antibacterial activity against ffteen oral microflora pathogen strains. The volatile oil sample investigated in this work contained mainly thymol (57.4%), carvacrol (13.5%), γ-terpinene (5.6%), and p-cymene (5.2%). The in vitro antibacterial experiments revealed that on tested bacteria the minimum inhibitory concentration (MIC) ranged 40–80 µL/Land the minimum bactericidal concentration (MBC) 80–150 µL/L. These findings support the idea that the C. aromaticus essential oil sample tested here could be suitable for use as a natural active ingredient in natural and low-cost drugs against oral microflora.


Journal of Essential Oil Bearing Plants | 2007

Chemical Composition of Hyptis pectinata L., H. lanceolata Poit , H. suaveolens (L) Poit and H. spicigera Lam. Essential Oils from Togo

Koffi Koba; C. Raynaud; J. Millet; J.-P. Chaumont; Komla Sanda

Abstract Essential oils of Hyptis pectinata L. (leaves and flowers), H. lanceolata Poit,(leaves), H. suaveolens (L) Poit (leaves and flowers) and H. spicigera Lan. (leaves) harvested in Togo were obtained by hydrodistillation and analysed by GC and GC-MS. The main constituents of the essential oils were respectively caryophylene oxide (32.7 %), humulene epoxide (9.3 %) for Hyptis pectinata and germacrene D (27.8 %), β-caryophyllene (12.6 %) and β-elemene (9.5 %) for H. lanceolata oil sample. In the H. spicigera essential oil sample β-caryophyllene (33.8 %), α-bergamotene (11.3 %) and α-caryophyllene (7.4 %) were found as the major constituents. In the H. suaveolens essential oil, sabinene (28.0 %) and β-caryophyllene (25.8 %) were mentioned as major constituents of the essential oil.


Journal of Essential Oil Bearing Plants | 2016

Investigation of Insecticidal Activity of Blend of Essential Oil of Cymbopogon schoenanthus and neem oil on Plutella xylostella (Lepidoptera: Plutellidae)

Lankondjoa Kolani; Komla Sanda; Komi Agboka; Gbénonchi Mawussi; Koffi Koba; Rousseau Djouaka

Abstract Plant and plant derived materials appear nowadays as a safe alternative to conventional pesticides to fight against crop pests. For this purpose, activity of blend (1:1 weight/weight) of Cymbopogon schoenanthus essential oil and neem (Azadirachta indica) seed oil on diamondback moth (Plutella xylostella) through contact and feeding methods were investigated and compared to each individual botanical. In the contact method, the combination of Cymbopogon schoenanthus/Azadirachta indica (LC50 = 23.3 mg/ml) oils exhibited medium activity showing higher toxicity than neem oil (58.39 mg/ml) and lower toxicity than Cymbopogon schcoenanthus essential oil (LC50 = 12.08 mg/ml). In feeding method, the toxicity resulted from the blend of Cymbopogon schoenanthus/Azadirachta indica (LC50 = 47.02) was slightly higher than both considered separately (LC50 = 52.39 and 53.63 for Cymbopogon schcoenanthus and neem respectively). Neem oil and the blend of Cymbopogon schoenanthus /neem exhibit strong antifeedance effect and inhibition of adult emergence of Plutella xylostella. The interaction between the mixture of Cymbopogon schoenanthus/ neem was additive resulting in increasing of insecticidal spectrum and could be used as an alternative to chemical pesticide in cabbage protection against Plutella xylostella.


Journal of biologically active products from nature | 2011

Antibacterial Activities of the Buds Essential Oil of Syzygium aromaticum (L.) Merr. & Perry from Togo

Koffi Koba; Amen Yawo Nenonene; Christine Raynaud; Jean-Pierre Chaumont; Komla Sanda

Abstract The buds essential oil of Syzygium aromaticum (Myrtaceae) from Togo were steam-distilled and investigated for percentage composition and antimicrobial activity. Eugenol (82.95 %), eugenyl acetate (5.01 %), β-caryophyllène (3.14 %) were the major components of the analysed sample. The in vitro microbiological experiments revealed that on tested bacteria, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) ranged from 30 to 50 μl/L and from 60 to 120 μl/L respectively. This makes S. aromaticum suitable for use as a source of active ingredients in the formulation of natural toothpaste and lotions for mouth washes.

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Christine Raynaud

Institut national de la recherche agronomique

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Jean-Pierre Chaumont

University of Franche-Comté

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