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Kohki Kiyoshima

Mercian Corporation

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Publication

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Journal of Chromatography A | 1983

Thin-layer chromatographic analysis of carbapenem antibiotics in fermentation broths

Mitsuyasu Okabe; Kohki Kiyoshima; Ikuo Kojima; Rokuro Okamoto; Yasuo Fukagawa; Tomoyuki Ishikura

Abstract A one-dimensional silica gel thin-layer chromatographic method has been devised for qualitative and quantitative analysis of carbapenem antibiotics in fermentation broths. The antibiotics were extracted from the broth filtrate with a solvent mixture of 1-butanol and chloroform (1:1) and developed on a silica gel thin-layer plate with a mobile phase of acetonitrile—0.75% acetic acid (9:2). Carbapenem compounds on the thin-layer plate were visualized as reddish pink spots with the Ehrlich reagent and quantitated by densitometry.

The Journal of Antibiotics | 1980

BIOLOGICAL PROPERTIES OF NEW ACYL DERIVATIVES OF TYLOSIN

Rokuro Okamoto; Masami Tsuchiya; Hideo Nomura; Hiroshi Iguchi; Kohki Kiyoshima; Senji Hori; Taiji Inui; Tsutomu Sawa; Tomio Takeuchi; Hamao Umezawa

The Journal of Antibiotics | 1981

New anthracyclines, feudomycins, produced by the mutant from Streptomyces coeruleorubidus ME130-A4.

Toshikazu Oki; Yasue Matsuzawa; Kohki Kiyoshima; Akihiro Yoshimoto; Hiroshi Naganawa; Tomio Takeuchi; Hamao Umezawa

The Journal of Antibiotics | 1980

PHYSICO-CHEMICAL PROPERTIES OF NEW ACYL DERIVATIVES OF TYLOSIN PRODUCED BY MICROBIAL TRANSFORMATION

Rokuro Okamoto; Tsumoru Fukumoto; Hideo Nomura; Kohki Kiyoshima; Kenji Nakamura; Akira Takamatsu; Hiroshi Naganawa; Tomio Takeuchi

The Journal of Antibiotics | 1982

STUDIES OF TYLOSIN DERIVATIVES EFFECTIVE AGAINST MACROLIDE-RESISTANT STRAINS: SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS

Masami Tsuchiya; Masa Hamada; Tomio Takeuchi; Hamao Umezawa; Kenichi Yamamoto; Hiroshi Tanaka; Kohki Kiyoshima; Shunro Mori; Rokuro Okamoto

The Journal of Antibiotics | 1980

PS-6 and PS-7, new .BETA.-lactam antibiotics. Isolation, physicochemical properties and structures.

Norio Shibamoto; Akihiko Koki; Masayoshi Nishino; Kosumi Nakamura; Kohki Kiyoshima; Kazuhiko Okamura; Mitsuyasu Okabe; Rokuro Okamoto; Yasuo Fukagawa; Yasutaka Shimauchi; Tomoyuki Ishikura

The Journal of Antibiotics | 1982

NEW MACROLIDE ANTIBIOTICS PRODUCED BY MUTANTS FROM STREPTOMYCES FRADIAE NRRL 2702

Rokuro Okamoto; Kohki Kiyoshima; Masao Yamamoto; Kazuaki Takada; Tetsuo Ohnuki; Tomoyuki Ishikura; Hiroshi Naganawa; Kuniaki Tatsuta; Tomio Takeuchi; Hamao Umezawa

The Journal of Antibiotics | 1989

STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON 4''-O-ACYLTYLOSIN DERIVATIVES: SIGNIFICANCE OF THEIR 23-O-MYCINOSYL AND 4''-O-ACYL MOIETIES IN ANTIMICROBIAL ACTIVITY AGAINST MACROLIDE-RESISTANT MICROBES

Kohki Kiyoshima; Michiko Sakamoto; Hideo Nomura; Takeo Yoshioka; Rokuro Okamoto; Tsutomu Sawa; Hiroshi Naganawa; Tomio Takeuchi

Chemical & Pharmaceutical Bulletin | 1989

Application of dibutyltin oxide method to regioselective acylation and alkylation of tylosin at C-4''.

Kohki Kiyoshima; Michiko Sakamoto; Tomoyuki Ishikura; Yasuo Fukagawa; Takeo Yoshioka; Hiroshi Naganawa; Tsutomu Sawa; Tomio Takeuchi

The Journal of Antibiotics | 1988

Synthesis and structure-activity studies of new 4"-O-acyltylosin derivatives of therapeutic interest.

Takeo Yoshioka; Kohki Kiyoshima; Miharu Maeda; Michiko Sakamoto; Tomoyuki Ishikura; Yasuo Fukagawa; Tsutomu Sawa; Masa Hamada; Hiroshi Naganawa; Tomio Takeuchi

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Rokuro Okamoto

Mercian Corporation

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Tomio Takeuchi

Keio University

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Tomoyuki Ishikura

Mercian Corporation

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Yasuo Fukagawa

Mercian Corporation

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Hiroshi Naganawa

Gunma University

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Takeo Yoshioka

Mercian Corporation

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Masao Yamamoto

Nippon Medical School

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Tsutomu Sawa

Keio University

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Hamao Umezawa

Hiroshima University

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Hiroshi Tone

Mercian Corporation

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