Kohsaku Nitta
Hiroshima University
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Featured researches published by Kohsaku Nitta.
Surgery Today | 1995
Seiji Marubayashi; Toshimasa Asahara; Eiji Ono; Hirotaka Tashiro; Koji Okugawa; Tatsuya Okimoto; Osamu Sanada; Hideki Nakahara; Takaji Maeda; Kohsaku Nitta; Yoshio Oshiro; Hideto Sakimoto; Naoshi Shigeta; Masahiro Nishihara; Masahiro Furukawa; Hiroshi Watanabe; Hiroshi Yahata; Yasuhiko Fukuda; Kiyohiko Dohi
Fulminant hepatic failure is usually fatal without liver transplantation; however, orthotopic liver transplantation is often difficult to perform due to the high risk of coagulopathy and the development of multiple organ failure. Auxiliary heterotopic partial liver transplantation (APLT), however, has the potential to provide an effective hepatic support system considering that the host liver is left in situ and the surgical procedure is less invasive. In this report, we describe the beneficial effects of performing 60% APLT on the hepatic function and survival of pigs with acute hepatic failure induced by hepatic artery ligation. The pigs were divided into a control group of nine animals (group 1) that had portal vein and hepatic artery ligation with a side-to-side portacaval shunt, and an APLT group of seven animals (group 2) that had portal vein and hepatic artery ligation with APLT. The two left lateral lobes of the donor liver were resected, reducing the liver weight to about 60%, and the graft was placed in the right subhepatic space. No deaths occurred intraoperatively. In group 1, eight pigs died of massive liver necrosis within 48 h and one died between 48 and 72 h (median surivival 23 h). In group 2, two pigs died within 72 h due to preservation or anesthetic problems, but five survived for more than 3 days (median survival 13.4 days), with a significant difference between the two groups (P<0.05). One animal was killed 30 days after APLT and excellent graft function was demonstrated by the synthesis of clotting factors, ammonia detoxification, and glucohomeostasis. Moreover, evidence of hepatic regeneration was found in the transplanted livers. These results indicate that APLT provides metabolic support and improves survival in animals with induced acute liver failure.
Hiroshima journal of medical sciences | 2011
Toshihide Harada; Fumiko Ishizaki; Nobuko Horie; Yumiko Nitta; Tohru Yamada; Tomohiro Sasaki; Tomoomi Nagakane; Yoshiteru Yasumatsu; Kohsaku Nitta; Hiroyuki Katsuoka
Autonomic Neuroscience: Basic and Clinical | 2010
Toshihide Harada; Fumiko Ishizaki; Maki Hamada; Nobuko Horie; Yumiko Nitta; Kohsaku Nitta; Hiroyuki Katsuoka; Shigenobu Nakamura
Hiroshima journal of medical sciences | 2014
Satomi Aoi; Takashi Miyake; Toshihide Harada; Fumiko Ishizaki; Hiromi Ikeda; Yumiko Nitta; Tadayuki Iida; Chiho Chikamura; Noriko Tamura; Kohsaku Nitta; Hideki Miyaguchi
Hiroshima journal of medical sciences | 2014
Toshihide Harada; Yuuki Iwakawa; Hiromi Ikeda; Fumiko Ishizaki; Satomi Aoi; Yumiko Nitta; Akira Yoshida; Noriko Tamura; Tadayuki Iida; Mitsuhisa Shiokawa; Kohsaku Nitta
Hiroshima journal of medical sciences | 2011
Toshihide Harada; Fumiko Ishizaki; Nobuko Horie; Hiroyuki Katsuoka; Yumiko Nitta; Tohru Yamada; Kohsaku Nitta; Makoto Ito
Hiroshima journal of medical sciences | 2007
Keiko Tsuboi; Yukiko Minegishi; Toshihide Harada; Fumiko Ishizaki; Kohsaku Nitta
Hiroshima journal of medical sciences | 1996
Kohsaku Nitta
Hiroshima journal of medical sciences | 2017
Yumiko Nitta; Yumiko Miki; Satomi Aoi; Hiromi Ikeda; Tadayuki Iida; Chiho Chikamura; Noriko Tamura; Kohsaku Nitta; Hideki Miyaguchi; Toshihide Harada; Fumiko Ishizaki
International Medical Journal | 2011
Toshihide Harada; Fumiko Ishizaki; Yumiko Nitta; Satomi Aoi; Hiromi Ikeda; Juko Ando; Kohsaku Nitta; Makoto Ito