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Dive into the research topics where Koji Ebisumoto is active.

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Featured researches published by Koji Ebisumoto.


Laryngoscope | 2010

New techniques to detect unknown primaries in cervical lymph node metastasis

Akihiro Sakai; Kenji Okami; Koji Ebisumoto; Ryosuke Sugimoto; Daisuke Maki; Masahiro Iida

Various methods have been reported for the detection of unknown primaries in cervical lymph node metastasis. Recently, we applied new optical devices and modifications of endoscopic techniques for the detection of primary lesions, and obtained excellent results. The detection rate of the new method was compared with that of previous methods.


Acta Oto-laryngologica | 2012

Prevention of wound complications in salvage pharyngolaryngectomy by the use of well-vascularized flaps

Akihiro Sakai; Kenji Okami; Ryousuke Sugimoto; Koji Ebisumoto; Hikaru Yamamoto; Daisuke Maki; Taku Atsumi; Masahiro Iida

Abstract Conclusions: We successfully reduced the incidence of pharyngocutaneous fistulas (PCFs) in high-risk patients undergoing surgery by using pectoralis major myocutaneous flaps (PMMCFs) and deltopectoral flaps (DPFs) to cover suture lines. Objectives: We used coverage of suture lines with PMMCFs and DPFs in patients with high risk of PCFs undergoing total laryngectomy (TL) or total pharyngolaryngectomy (TPL) to determine whether coverage of suture lines during salvage surgery can reduce the incidence of PCFs. Methods: This retrospective study was based on a review of 52 patients who underwent salvage TL or TPL between 2001 and 2011; we have been using PMMCFs or DPFs during salvage surgery since 2008. Details of postoperative complications including PCFs were analyzed. Results: The incidence rate of PCF was lower in the flap group (7.7%) than that in the non-flap group (30.1%). No carotid ruptures were observed in the flap group (0%) as contrasted with patients in the non-flap group (7.7%).


Head and Neck-journal for The Sciences and Specialties of The Head and Neck | 2013

Transoral en bloc resection of superficial laryngeal and pharyngeal cancers

Kenji Okami; Koji Ebisumoto; Akihiro Sakai; Ryousuke Sugimoto; Daisuke Maki; Kosuke Saito; Shoji Kaneda; Masahiro Iida; Go Ogura; Naoya Nakamura; Koichiro Nishiyama

The objective of this study was to evaluate the efficacy and safety of minimally invasive transoral en bloc resection of superficial pharyngeal and laryngeal cancers.


Auris Nasus Larynx | 2014

A new technique to expose the hypopharyngeal space: The Modified Killian's method

Akihiro Sakai; Kenji Okami; Ryousuke Sugimoto; Koji Ebisumoto; Hikaru Yamamoto; Daisuke Maki; Kosuke Saito; Masahiro Iida

OBJECTIVEnRecent remarkable progress in endoscopic technology has enabled the detection of superficial cancers that were undetectable in the past. However, even though advanced endoscopic technology can detect early lesions, it is useless unless it can provide wide exposure of an area. By modifying the Killian position, it is possible to observe a wider range of the hypopharyngeal space than is possible with conventional head positions. We report a revolutionary method that uses a new head position to widely open the hypopharynx. The technique is named the Modified Killians method.nnnMETHODSnThe patient is initially placed in the Killian position and then bent further forward from the original position (i.e., the modified Killian position). While in this position, the patients head is turned and the Valsalva maneuver is applied. These additional maneuvers constitute the Modified Killians method and widely expands the hypopharyngeal space.nnnRESULTSnThe conventional head position cannot open the hypopharyngeal space sufficiently; however, the Modified Killians method opens the hypopharyngeal space very widely.nnnCONCLUSIONnThe Modified Killians method enables observation of the entire circumference of the hypopharyngeal space and the cervical esophageal entry. The Modified Killians method may become an indispensable technique for observing the hypopharynx and detecting hypopharyngeal cancers.


Operations Research Letters | 2011

Multivariate Analysis of Wound Complications after Surgery for Laryngeal and Hypopharyngeal Cancers

Akihiro Sakai; Kenji Okami; Ryousuke Sugimoto; Koji Ebisumoto; Hikaru Yamamoto; Hiroyuki Furuya; Masahiro Iida

Purpose: The aim of this study was to identify the factors leading to postoperative complications following surgical management of laryngeal and hypopharyngeal cancers. Procedures: Between 2001 and 2008, the medical records of 107 laryngeal and hypopharyngeal cancer patients requiring laryngectomy or pharyngolaryngectomy at our hospital were reviewed. The incidence of wound complications and correlation of complications with clinicopathological factors were investigated by univariate and multivariate analysis. Results: The overall incidence of wound complication was 33.6%. The complication incidence was 35.2, 21.7 and 46.2% for the primary surgery, radiation and chemoradiation groups, respectively. Diabetes mellitus and bilateral paratracheal node dissection were significantly correlated and were independent risk factors according to multivariate analysis. Bleeding from a large vessel occurred in 4 patients, and there were significant correlations with chemoradiation. Conclusion: Preoperative chemoradiation was not a significant risk factor for wound complication in this study. However, once postoperative wound complications occurred, they tended to produce lethal outcomes.


Oncotarget | 2017

Biomarker immunoprofile in salivary duct carcinomas: clinicopathological and prognostic implications with evaluation of the revised classification

Soichiro Takase; Satoshi Kano; Yuichiro Tada; Daisuke Kawakita; Tomotaka Shimura; Hideaki Hirai; Kiyoaki Tsukahara; Akira Shimizu; Yorihisa Imanishi; Hiroyuki Ozawa; Kenji Okami; Yuichiro Sato; Yukiko Sato; Chihiro Fushimi; Takuro Okada; Hiroki Sato; Kuninori Otsuka; Yoshihiro Watanabe; Akihiro Sakai; Koji Ebisumoto; Takafumi Togashi; Yushi Ueki; Hisayuki Ota; Toyoyuki Hanazawa; Hideaki Chazono; Robert Yoshiyuki Osamura; Toshitaka Nagao

Salivary duct carcinoma (SDC) is an uncommon, aggressive malignant neoplasm histologically resembling high-grade mammary ductal carcinoma. SDC can arise de novo or ex pleomorphic adenoma. To clarify the correlation of biomarker immunoprofile with clinicopathological findings and clinical outcome of SDC, we conducted immunohistochemistry for EGFR, HER2, HER3, AR, CK5/6, p53, and Ki-67, along with HER2 fluorescence in situ hybridization in 151 SDCs. SDCs ex pleomorphic adenoma more commonly overexpressed EGFR, HER2, HER3, and Ki-67 than de novo SDCs (P = 0.015, < 0.001, 0.045, and 0.02, respectively). In multivariate analysis, AR− and CK5/6+ were associated with shorter progression-free survival (P = 0.027 and 0.004, respectively). Moreover, patients with p53-extreme negative/positive demonstrated poorer overall survival (P = 0.007). On assessing the revised classification by the combination of biomarker expression, the percentages of each subtype were as follows: ‘apocrine A’ (AR+/HER2−/Ki-67-low) (24%), ‘apocrine B’ (AR+/HER2−/Ki-67-high) (18%), ‘apocrine HER2’ (AR+/HER2+) (35%), ‘HER2-enriched’ (AR−/HER2+) (12%), and ‘double negative’ (AR−/HER2−) (11%). ‘Double negative’ was further subclassified into ‘basal-like’ (EGFR and/or CK5/6+) (7%) and ‘unclassified’ (3%). Consequently, patients with ‘apocrine A’ showed a better progression-free survival than those with any other subtypes. Our revised immunoprofiling classification was valuable for predicting the survival and might be useful in personalized therapy for patients with SDC.


Head and Neck-journal for The Sciences and Specialties of The Head and Neck | 2016

Successful detection of a minute tonsillar cancer lesion on transoral examination with narrow band imaging: A report of 2 cases.

Koji Ebisumoto; Kenji Okami; Akihiro Sakai; Ryousuke Sugimoto; Masahiro Iida

The improvement of optical enhancement devices, such as narrow band imaging (NBI), has enabled us to visualize lesions that cannot be seen upon macroscopic examination. NBI is useful for detecting subtle lesions, including the primary sites of occult primary cancer.


Oncotarget | 2017

Impact of hematological inflammatory markers on clinical outcome in patients with salivary duct carcinoma: a multi-institutional study in Japan

Daisuke Kawakita; Yuichiro Tada; Yorihisa Imanishi; Shintaro Beppu; Kiyoaki Tsukahara; Satoshi Kano; Hiroyuki Ozawa; Kenji Okami; Yuichiro Sato; Akira Shimizu; Yukiko Sato; Chihiro Fushimi; Soichiro Takase; Takuro Okada; Hiroki Sato; Kuninori Otsuka; Yoshihiro Watanabe; Akihiro Sakai; Koji Ebisumoto; Takafumi Togashi; Yushi Ueki; Hisayuki Ota; Tomotaka Shimura; Toyoyuki Hanazawa; Shingo Murakami; Toshitaka Nagao

The prognostic role of modified Glasgow Prognostic Score (mGPS), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with salivary duct carcinoma (SDC) remains unclear. We conducted a multi-institutional retrospective cohort study of 140 SDC patients. The survival impact of these hematological markers was evaluated using multivariate proportional hazard models.High mGPS (≥1) was significantly associated with worse survival (3-year overall survival (OS): 16.7% vs 66.1%, p-value=0.003; 3-year progression-free survival (PFS): 0.0% vs 27.9%, p-value<0.001). Additionally, high C-reactive protein (CRP) (≥0.39 mg/dl) was significantly associated with worse survival (3-year OS: 32.1% vs 68.2%, p-value=0.001; 3-year PFS: 7.1% vs 31.1%, p-value<0.001). These associations were consistent with multivariate analysis adjusted for established prognostic factors. Although we also found significant association of high NLR (≥2.5) with OS (HR 1.80; 95% confidence interval, 1.05-3.08) in multivariate analysis, this association were inconsistent with the results of PFS. In addition, we found no significant associations of PLR with survival. In conclusion, we found that mGPS, CRP and NLR were identified as prognostic factors associated with survival in SDC patients.


Acta Oto-laryngologica | 2015

The potential risk of vessel infiltration and cervical lymph node metastasis in hypopharyngeal superficial squamous cell carcinoma: a retrospective observational study

Koji Ebisumoto; Kenji Okami; Akihiro Sakai; Go Ogura; Ryousuke Sugimoto; Kosuke Saito; Kaoru Komita; Naoya Nakamura; Masahiro Iida

Abstract Conclusion: The depth of hypopharyngeal superficial cancer may predict vessel infiltration and potential risk of cervical lymph node metastasis. Objectives: To elucidate the histopathological predictors of vessel infiltration and the risk of regional lymph node metastasis in hypopharyngeal superficial cancer. Methods: This study included 31 lesions from 30 patients who had undergone transoral en bloc resection in the hospital. Patients with intraepithelial neoplasia or muscular invasion were excluded. Patient characteristics, nodal status, state of vessel infiltration, state of perineural invasion, histopathological parameters, and post-operative cervical lymph node recurrence were retrospectively examined. The histopathological parameters measured were tumor diameter and the following three parameters: tumor thickness, depth from the mucosal surface, and depth from the basement membrane. Correlations between histopathological parameters and state of vessel infiltration were statistically analyzed. Results: Of the 31 lesions examined, four had vessel infiltration. Three of the four lesions with vessel infiltration had regional lymph node metastasis as well as subsequent lymph node metastasis. Lesions with vessel infiltration were significantly deeper than those without. In contrast, there was no significant difference in lesion diameters. In addition, there was no correlation between the depth and the diameter of the lesion.


Head and Neck-journal for The Sciences and Specialties of The Head and Neck | 2013

Evaluating the significance of level IIb neck dissection for hypopharyngeal cancer.

Akihiro Sakai; Kenji Okami; Ryousuke Sugimoto; Koji Ebisumoto; Hikaru Yamamoto; Daisuke Maki; Taku Atsumi; Kosuke Saito; Masahiro Iida

This study evaluated cervical lymph node metastases at level IIb in cases of hypopharyngeal cancer and analyzed the possibility of preservation of level IIb during neck dissection.

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Akihiro Sakai

Wakayama Medical University

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