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Koji Ishikura

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Featured researches published by Koji Ishikura.

Tetrahedron Letters | 1979

Synthetic studies on β-lactam antibiotics. 15. conversion of 7-epicephems into 1-oxacephems☆

Yoshio Hamashima; Tadatoshi Kubota; Koji Ishikura; Wataru Nagata

Abstract 7-Epi-1-oxacephem was obtained by stereospecific, intramolecular etherification of alcohol prepared from 7-epicephems via aldehyde or formate. Synthesis of the 3-acetoxymethyl analogwas unsuccessful. Biologically active 1-oxacephems were derived from by known processes.

Tetrahedron Letters | 1979

Synthetic studies on β-lactam antibiotics. 19. Synthesis of 3′-nor-type 1-oxacephems☆

Yoshio Hamashima; Sadao Yamamoto; Tadatoshi Kubota; Katsuya Tokura; Koji Ishikura; Kyogi Minami; Fumihiko Matsubara; Masaaki Yamaguchi; Ikuo Kikkawa; Wataru Nagata

Abstract Synthesis of optically active 3′-nor-type 1-oxacephems from 6-APA was described. p -Nitrobenzyl 7β-amino-3-chloro-7α-methoxy-1-oxa-3-cephem-4-carboxylate 39 was also prepared.

The Journal of Antibiotics | 2002

S-3578, a new broad spectrum parenteral cephalosporin exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Synthesis and structure-activity relationships.

Hidenori Yoshizawa; Hikaru Itani; Koji Ishikura; Tadashi Irie; Katsuki Yokoo; Tadatoshi Kubota; Kyoji Minami; Tsutomu Iwaki; Hideaki Miwa; Yasuhiro Nishitani

The Journal of Antibiotics | 1987

Synthesis and biological properties of 7.BETA.-((Z)-2-(2-amino-4-thiazolyl)-4-carboxy-2-butenoylamino)-3-cephem-4-carboxylic acid (7432-S), a new oral cephem antibiotic.

Yoshio Hamashima; Tadatoshi Kubota; Kyoji Minami; Koji Ishikura; Toshiro Konoike; Mitsuru Yoshioka; Tadashi Yoshida; Hiromu Nakashimizu; Kiyoshi Motokawa

The Journal of Antibiotics | 1994

Synthesis and structure-activity relationships of 7 beta-[(Z)-2-(2- aminothiazol-4-yl)-3-(substituted)-2-propenoylamino]-3-cephems with C-3 substitutions.

Koji Ishikura; Tadashi Kubota; Kyoji Minami; Yoshio Hamashima; Hiromu Nakashimizu; Kiyoshi Motokawa; Yasuo Kimura; Hideaki Miwa; Tadashi Yoshida

ChemInform | 1979

Synthetic studies on .beta.-lactam antibiotics. 12. Stereocontrolled synthesis of 7.alpha.-methoxy-1-oxacephems from 6-epipenicillin G

Shoichiro Uyeo; I. Kikkawa; Yoshio Hamashima; H. Ona; Y. Nishitani; Kyo Okada; Tadatoshi Kubota; Koji Ishikura; Y. Ide; K. Nakano; Wataru Nagata

ChemInform | 1976

SYNTHESIS OF 3-SUBSTITUTED CEPHEMS FROM PENICILLINS VIA 4-DITHIO-2-AZETIDINONE INTERMEDIATES

Yoshio Hamashima; Tadatoshi Kubota; Koji Ishikura; Kyoji Minami; Kazuya Tokura; Wataru Nagata

Archive | 1986

Oxoheterocyclic carbonamido)cephem carboxylic acid derivatives

Yoshio Hamashima; Koji Ishikura; Tadatoshi Kubota; Kyoji Minami

The Journal of Antibiotics | 1994

Synthesis and structure-activity relationships of 7.BETA.-((Z)-2-(2-aminothiazol-4-yl)-3-(substituted)-2-propenoyl-amino)-3-desacetoxymethylcephalosporins.

Koji Ishikura; Tadatoshi Kubota; Kyoji Minami; Yoshio Hamashima; Hiromu Nakashimizu; Kiyoshi Motokawa; Tadashi Yoshida

Archive | 1975

Antibacterial hydrazono cephalosporins

Mitsuru Yoshioka; Yuji Sendo; Koji Ishikura; Masayuki Murakami; Sadao Miyazaki

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Yoshio Hamashima

Kyoto Pharmaceutical University

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Tadashi Yoshida

Tohoku University

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Wataru Nagata

Teijin

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Yuji Sendo

Hokkaido University

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Tetsuo Okada

Mukogawa Women's University

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Kyo Okada

Teijin

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Shoichiro Uyeo

Kyoto University

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Toshiro Konoike

Kyoto University

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Yasuhiro Nishitani

Massachusetts Institute of Technology

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