Kongara Damodar

Organic Reactions in Water: A Distinct Novel Approach for an Efficient Synthesis of α-Amino Phosphonates Starting Directly from Nitro Compounds†

A distinct approach for high-yielding synthesis of alpha-amino phosphonates has been discovered through three-component reaction of nitro compounds, aldehydes, or ketones and dialkyl or trialkyl phosphites using indium in dilute aqueous HCl at room temperature. This one-pot conversion consists of the following steps: (i) reduction of nitro compounds to amines, (ii) formation of imines from amines and carbonyl compounds, and (iii) hydrophosphonylation of imines.

Efficient Bromination of Alkenes and Alkynes Using Potassium Bromide and Diacetoxy Iodobenzene

Abstract Bromination of alkenes and alkynes has efficiently been carried out at room temperature in short reaction times using KBr and diacetoxy iodobenzene in CH2Cl2-H2O (1:1) to prepare the corresponding trans-dibromo compounds in excellent yields.

Simple and Advantageneous Stereoselective Synthesis of (Z)-Allyl Phosphonates Starting from Baylis–Hillman Adducts

Abstract Baylis–Hillman adducts 3-hydroxyl-2-methylene alkanoates have been converted in one pot into the corresponding (Z)-allyl phosphonates by treatment with FeCl3 and trialkyl phosphites in toluene under reflux. The products are formed in excellent yields (88–98%) within 1–1.5 h. The process is highly convenient and efficient, cost-effective, and remarkably stereoselective. GRAPHICAL ABSTRACT

Rapid, efficient and selective conjugate addition of thiols to α, β-unsaturated carbonyl compounds using silica supported sodium hydrogen sulfate under solvent-free conditions†

The conjugate addition of thiols to α, β-unsaturated carbonyl compounds was carried out rapidly (within 2–5 min) and selectively in the presence of silica supported sodium hydrogen sulfate (NaHSO4·SiO2) to form the corresponding Michael adducts in excellent yields (86–95%) at room temperature and under solvent-free conditions. †Part 157 in the series, ‘Studies on novel synthetic methodologies’