Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Konstantinos Vlachos is active.

Publication


Featured researches published by Konstantinos Vlachos.


OncoTargets and Therapy | 2014

Potential of antibody–drug conjugates and novel therapeutics in breast cancer management

Georgios D Lianos; Konstantinos Vlachos; Odysseas Zoras; Christos Katsios; William C Cho; Dimitrios H Roukos

Progress in the treatment of cancer over the past decade has been slow. Targeting a mutated gene of an individual patient tumor, tumor-guided agents, and the first draft of the human genome sequence have created an overenthusiasm to achieve personalized medicine. However, we now know that this effort is misleading. Extreme interpatient and intratumor heterogeneity, scarce knowledge in how genome-wide mutational landscape and epigenetic changes affect transcriptional processes, gene expression, signaling transduction networks and cell regulation, and clinical assessment of temporary efficacy of targeted drugs explain the limitations of these currently available agents. Trastuzumab and a few other monoclonal antibodies or small-molecule tyrosine kinase inhibitors (TKIs) represent an exception to this rule. By blocking ligand-binding receptor in patients with human epidermal growth factor receptor 2 (HER2) amplification and overexpression, trastuzumab added to chemotherapy in HER2-positive patients has been proven to provide significant overall survival benefit in both metastatic and adjuvant settings. Lapatinib, a small-molecule dual inhibitor (TKI) of both HER2 and EGFR (epidermal growth factor receptor) pathways, has an antitumor activity translated into progression-free survival benefit in HER2-positive metastatic patients previously treated with a taxane, an anthracycline, and trastuzumab. Despite these advances, ~25% of patients with HER2-positive breast cancer experience recurrence in the adjuvant setting, while in the metastatic setting, median survival time is 25 months. In this review, we discuss the safety, efficacy, and limitations of the trastuzumab emtansine (T-DM1) conjugate in the treatment of HER2-positive metastatic breast cancer. We also highlight Phase III randomized trials, currently underway, using either the T-DM1 conjugate or various combinations of monoclonal antibodies and TKIs. Moreover, in contrast with all these agents developed on the basis of “central dogma” of simplified reductionist transcription and single gene–phenotype linear relationship, we summarize the emerging, amazing era of next-generation, transcriptional circuitry and intracellular signaling network-based drugs guided by the latest advances in genome science and dynamics of network biology.


World Journal of Emergency Surgery | 2011

Multiple giant diverticula of the jejunum causing intestinal obstruction: report of a case and review of the literature.

Evangelos Falidas; Konstantinos Vlachos; Stavros Mathioulakis; Fotis Archontovasilis; Constantinos Villias

Multiple diverticulosis of jejunum represents an uncommon pathology of the small bowel. The disease is usually asymptomatic and must be taken into consideration in cases of unexplained malabsorption, anemia, chronic abdominal pain or discomfort. Related complications such as diverticulitis, perforation, bleeding or intestinal obstruction appear in 10-30% of the patients increasing morbidity and mortality rates. We herein report a case of a 55 year-old man presented at the emergency department with acute abdominal pain, vomiting and fever. Preoperative radiological examination followed by laparotomy revealed multiple giant jejunal diverticula causing intestinal obstruction. We also review the literature for this uncommon disease.


World Journal of Surgical Oncology | 2011

Primary retroperitoneal mucinous cystadenoma of borderline malignancy in a male patient. Case report and review of the literature

Evangelos Falidas; Stefanos Konstandoudakis; Konstantinos Vlachos; Fotios Archontovasilis; Stavros Mathioulakis; Stavros Boutzouvis; Constantinos Villias

BackgroundPrimary retroperitoneal mucinous cystadenoma of borderline malignancy represents a rare tumor, with unclear histogenesis, concerning almost exclusively women. Only two cases concerning male patients have been reported.Case reportWe herein report a case of a 37 year old man undergone laparotomy for a sizable retroperitoneal tumor resulting after the histological examination to a primary retroperitoneal mucinous cystadenoma of borderline malignancy.ConclusionThis is the third case of primary retroperitoneal mucinous cystadenoma of borderline malignancy in a male patient reported in the literature. The preoperative diagnosis is impossible. Laparotomy constitutes the only diagnostic and curative approach.


Journal of Infection and Public Health | 2016

Human subcutaneous dirofilariasis caused by Dirofilaria immitis in a Greek adult

Evangelos Falidas; Stavros Gourgiotis; Olga Ivopoulou; Ioannis Koutsogiannis; Christianna Oikonomou; Konstantinos Vlachos; Constantinos Villias

Human dirofilariasis is a zoonotic infection caused by worms of the genus Dirofilaria. Most reported cases involve Dirofilaria repens, and D. immitis infection has been rarely reported. Canines act as a reservoir for the infection, while human infections are sporadic. Human dirofilariasis has been widely reported in South Europe; however, the worldwide distribution constantly changes. We herein report an extremely rare case of subcutaneous trunk dirofilariasis in a 45-year-old immunosuppressed woman, caused by D. immitis. The parasitic infection was detected using ultrasonography. The infection was confirmed by a polymerase chain reaction-based method and was attributed to D. immitis.


Case Reports in Surgery | 2013

Multicystic Hepatocarcinoma Mimicking Liver Abscess

Evangelos Falidas; Angelos Pazidis; Georgios Anyfantakis; Konstantinos Vlachos; Christina Goudeli; Constantinos Villias

The diagnosis of hepatocellular carcinoma (HCC) became easier in relation to the improved radiological examinations; however, the neoplasm may occur under atypical presentations mimicking other benign or malignant processes. Multicystic HCC mimicking a liver abscess associated with septic-type fever and leukocytosis is rare, has a poor prognosis, and poses diagnostic and therapeutic dilemmas. We present the case of an 80-year-old patient, who presented with fever, leukocytosis, and large cystic masses involving right and left lobes of the liver initially considered abscesses and finally diagnosed as HCC after open drainage and liver biopsy. Although the patient died on the tenth postoperative day due to pulmonary oedema, the authors emphasize the high index of suspicion needed in the diagnosis of this unusual presentation of HCC.


Case Reports in Surgery | 2013

Gastric Volvulus and Wandering Spleen: A Rare Surgical Emergency

Georgios D Lianos; Konstantinos Vlachos; Nikolaos Papakonstantinou; Christos Katsios; Georgios Baltogiannis; Dimitrios Godevenos

Gastric volvulus is a rare but potentially life-threatening clinical entity due to possible gastric necrosis. A wandering spleen may also be associated with gastric volvulus. Patients presenting with the triad epigastralgia, vomiting followed by retching, and difficulty or inability to pass a nasogastric tube into the stomach are likely to have gastric volvulus. The operating surgeon should include this rare entity in the differential diagnosis when dealing with a patient with such a clinical profile. Herein, we present a case of gastric volvulus associated with a wandering spleen in a 28-year-old Caucasian woman and we provide a brief review of the literature on this issue.


Case Reports in Surgery | 2012

Pneumoperitoneum, Retropneumoperitoneum, Pneumomediastinum, and Diffuse Subcutaneous Emphysema following Diagnostic Colonoscopy.

Evangelos Falidas; Georgios Anyfantakis; Konstantinos Vlachos; Christina Goudeli; Boutzouvis Stavros; Constantinos Villias

Colonoscopy is a widely used diagnostic and curative procedure. Extraperitoneal perforation with pneumoretroperitoneum, pneumomediastinum and subcutaneous emphysema combined with intraperitoneal perforation is an extremely rare complication. We report a case of a 78-year-old woman presented to the emergency department with abdominal pain and diffuse abdominal, chest, neck, and facial swelling appeared after a diagnostic colonoscopy. Diagnostic and therapeutic modalities are discussed.


International Journal of Surgery Case Reports | 2012

Strangulated intestinal hernia through a drain site

Evangelos Falidas; Stavros Mathioulakis; Konstantinos Vlachos; Emmanouil Pavlakis; Constantinos Villias

INTRODUCTION Intra-abdominal drains have been widely used in order to prevent intra-abdominal fluid accumulation and detection of anastomotic leakage. PRESENTATION OF CASE We herein report a case of small bowel herniation followed by strangulation in an 82 year old woman who had undergone sigmoidectomy for colorectal cancer. DISCUSSION Although several complications related to drain usage such as drainsite infection, hemorrhage and intestinal perforation may occur, intestinal incarceration through drain site is rarely reported. CONCLUSION Drains must be used with caution and only if indicated. Careful insertion, regular post-operative or post-removal inspection is strongly recommended.


International Journal of Surgery Case Reports | 2011

Traumatic mesenteric cyst after blunt abdominal trauma.

Evangelos Falidas; Stavros Mathioulakis; Konstantinos Vlachos; Emmanouil Pavlakis; Georgios Anyfantakis; Constantinos Villias

Mesenteric cysts are rare abdominal tumors of unclear histologic origin, usually asymptomatic. Post-traumatic mesenteric cyst usually results as a consequence of a mesenteric lymphangitic rupture or a hematoma followed by absorption and cystic degeneration. The preoperative histological and radiological diagnosis is difficult. We present the case of a 45-year-old male patient with sizable, palpable abdominal tumor, the gradual swelling of which the patient himself combined with the blunt abdominal trauma he acquired from an opponents knee in a football game 5 months ago.


Case Reports in Medicine | 2012

Recurrent Urinary Tract Infections due to Asymptomatic Colonic Diverticulitis

Evangelos Falidas; Georgios Anyfantakis; Stavros Boutzouvis; Michail Kyriakopoulos; Stavros Mathioulakis; Konstantinos Vlachos; Constantinos Villias

Colovesical fistula is a common complication of diverticulitis. Pneumaturia, fecaluria, urinary tract infections, abdominal pain, and dysuria are commonly reported. The authors report a case of colovesical fistula due to asymptomatic diverticulitis, and they emphasize the importance of deeply investigate recurrent urinary tract infection without any bowel symptoms. They also briefly review the literature.

Collaboration


Dive into the Konstantinos Vlachos's collaboration.

Top Co-Authors

Avatar

Constantinos Villias

United States Department of Veterans Affairs

View shared research outputs
Top Co-Authors

Avatar

Evangelos Falidas

United States Department of Veterans Affairs

View shared research outputs
Top Co-Authors

Avatar

Stavros Mathioulakis

United States Department of Veterans Affairs

View shared research outputs
Top Co-Authors

Avatar

Georgios Anyfantakis

United States Department of Veterans Affairs

View shared research outputs
Top Co-Authors

Avatar

Stavros Gourgiotis

Queen Mary University of London

View shared research outputs
Top Co-Authors

Avatar

Emmanouil Pavlakis

United States Department of Veterans Affairs

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Fotis Archontovasilis

National and Kapodistrian University of Athens

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge